Ribosomal Protein S6 Kinases, 70-kDa

"Ribosomal Protein S6 Kinases, 70-kDa" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A family of ribosomal protein S6 kinases that are considered the major physiological kinases for RIBOSOMAL PROTEIN S6. Unlike RIBOSOMAL PROTEIN S6 KINASES, 90KDa the proteins in this family are sensitive to the inhibitory effects of RAPAMYCIN and contain a single kinase domain. They are referred to as 70kDa proteins, however ALTERNATIVE SPLICING of mRNAs for proteins in this class also results in 85kDa variants being formed.

Descriptor ID	D038762
MeSH Number(s)	D08.811.913.696.620.682.700.862.249 D12.644.360.600.249 D12.776.476.600.249
Concept/Terms	Ribosomal Protein S6 Kinases, 70-kDa Ribosomal Protein S6 Kinases, 70-kDa Ribosomal Protein S6 Kinases, 70 kDa p70 S6 Kinase S6 Kinase, p70 p70s6k

Below are MeSH descriptors whose meaning is more general than "Ribosomal Protein S6 Kinases, 70-kDa".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
Ribosomal Protein S6 Kinases [D08.811.913.696.620.682.700.862]
Ribosomal Protein S6 Kinases, 70-kDa [D08.811.913.696.620.682.700.862.249]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
Ribosomal Protein S6 Kinases [D12.644.360.600]
Ribosomal Protein S6 Kinases, 70-kDa [D12.644.360.600.249]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
Ribosomal Protein S6 Kinases [D12.776.476.600]
Ribosomal Protein S6 Kinases, 70-kDa [D12.776.476.600.249]

Below are MeSH descriptors whose meaning is related to "Ribosomal Protein S6 Kinases, 70-kDa".

Below are MeSH descriptors whose meaning is more specific than "Ribosomal Protein S6 Kinases, 70-kDa".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in this website by year, and whether "Ribosomal Protein S6 Kinases, 70-kDa" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 3 publications in 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	3	3
2006	0	1	1
2010	0	1	1
2013	0	1	1
2015	1	1	2
2021	1	0	1
2024	0	1	1

Below are the most recent publications written about "Ribosomal Protein S6 Kinases, 70-kDa" by people in Profiles.

Lee HJ, Min L, Gao J, Matta S, Drel V, Saliba A, Tamayo I, Montellano R, Hejazi L, Maity S, Xu G, Grajeda BI, Roy S, Hallows KR, Choudhury GG, Kasinath BS, Sharma K. Female Protection Against Diabetic Kidney Disease Is Regulated by Kidney-Specific AMPK Activity. Diabetes. 2024 Jul 01; 73(7):1167-1177.

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Awah CU, Winter J, Mazdoom CM, Ogunwobi OO. NSUN6, an RNA methyltransferase of 5-mC controls glioblastoma response to temozolomide (TMZ) via NELFB and RPS6KB2 interaction. Cancer Biol Ther. 2021 12 02; 22(10-12):587-597.

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Carrillo JA, He Y, Luo J, Menendez KR, Tablante NL, Zhao K, Paulson JN, Li B, Song J. Methylome Analysis in Chickens Immunized with Infectious Laryngotracheitis Vaccine. PLoS One. 2015; 10(6):e0100476.

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Bratton MR, Martin EC, Elliott S, Rhodes LV, Collins-Burow BM, McLachlan JA, Wiese TE, Boue SM, Burow ME. Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer. J Steroid Biochem Mol Biol. 2015 Jun; 150:17-23.

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Ma KL, Liu J, Wang CX, Ni J, Zhang Y, Wu Y, Lv LL, Ruan XZ, Liu BC. Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation. Cardiovasc Res. 2013 Dec 01; 100(3):450-60.

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Edelstein J, Hao T, Cao Q, Morales L, Rockwell P. Crosstalk between VEGFR2 and muscarinic receptors regulates the mTOR pathway in serum starved SK-N-SH human neuroblastoma cells. Cell Signal. 2011 Jan; 23(1):239-48.

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Koul D, Shen R, Bergh S, Sheng X, Shishodia S, Lafortune TA, Lu Y, de Groot JF, Mills GB, Yung WK. Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma. Mol Cancer Ther. 2006 Mar; 5(3):637-44.

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Ha T, Li Y, Gao X, McMullen JR, Shioi T, Izumo S, Kelley JL, Zhao A, Haddad GE, Williams DL, Browder IW, Kao RL, Li C. Attenuation of cardiac hypertrophy by inhibiting both mTOR and NFkappaB activation in vivo. Free Radic Biol Med. 2005 Dec 15; 39(12):1570-80.

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Ha T, Li Y, Hua F, Ma J, Gao X, Kelley J, Zhao A, Haddad GE, Williams DL, William Browder I, Kao RL, Li C. Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload. Cardiovasc Res. 2005 Nov 01; 68(2):224-34.

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Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell. 2005 Apr 22; 121(2):179-93.

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