Carcinoma, Hepatocellular

"Carcinoma, Hepatocellular" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.

Descriptor ID	D006528
MeSH Number(s)	C04.557.470.200.025.255 C04.588.274.623.160 C06.301.623.160 C06.552.697.160
Concept/Terms	Carcinoma, Hepatocellular Carcinoma, Hepatocellular Carcinomas, Hepatocellular Hepatocellular Carcinomas Liver Cell Carcinoma, Adult Liver Cancer, Adult Adult Liver Cancer Adult Liver Cancers Cancer, Adult Liver Cancers, Adult Liver Liver Cancers, Adult Liver Cell Carcinoma Carcinoma, Liver Cell Carcinomas, Liver Cell Cell Carcinoma, Liver Cell Carcinomas, Liver Liver Cell Carcinomas Hepatocellular Carcinoma Hepatoma Hepatomas

Below are MeSH descriptors whose meaning is more general than "Carcinoma, Hepatocellular".

Diseases [C]
Neoplasms [C04]
Neoplasms by Histologic Type [C04.557]
Neoplasms, Glandular and Epithelial [C04.557.470]
Carcinoma [C04.557.470.200]
Adenocarcinoma [C04.557.470.200.025]
Carcinoma, Hepatocellular [C04.557.470.200.025.255]
Neoplasms by Site [C04.588]
Digestive System Neoplasms [C04.588.274]
Liver Neoplasms [C04.588.274.623]
Carcinoma, Hepatocellular [C04.588.274.623.160]
Digestive System Diseases [C06]
Digestive System Neoplasms [C06.301]
Liver Neoplasms [C06.301.623]
Carcinoma, Hepatocellular [C06.301.623.160]
Liver Diseases [C06.552]
Liver Neoplasms [C06.552.697]
Carcinoma, Hepatocellular [C06.552.697.160]

Below are MeSH descriptors whose meaning is related to "Carcinoma, Hepatocellular".

Below are MeSH descriptors whose meaning is more specific than "Carcinoma, Hepatocellular".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Carcinoma, Hepatocellular" by people in this website by year, and whether "Carcinoma, Hepatocellular" was a major or minor topic of these publications.

Bar chart showing 117 publications over 23 distinct years, with a maximum of 13 publications in 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	0	1	1
2004	0	1	1
2005	0	1	1
2006	6	1	7
2007	4	1	5
2008	2	0	2
2009	3	1	4
2010	4	0	4
2011	5	0	5
2012	7	2	9
2013	6	0	6
2014	4	0	4
2015	3	0	3
2016	9	1	10
2017	3	2	5
2018	3	0	3
2019	10	3	13
2020	6	1	7
2021	8	1	9
2022	1	0	1
2023	9	1	10
2024	1	0	1
2025	6	0	6

Below are the most recent publications written about "Carcinoma, Hepatocellular" by people in Profiles.

Gao Y, Chen W, Zarogoulidis P, Yallapu MM, Nikolic MV, Vaishnani DK, Zheng J, Nedeljkovic N, Ye K, Guo Y, Xu Q. Multiomics and experimental validation reveal theophylline's mechanism targeting IL1A/ACTB/TLR4 and identify synergistic drugs in hepatocellular carcinoma. J Pharmacol Exp Ther. 2026 Mar; 393(3):103836.

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Miyatani Y, Ogawa A, Sempokuya T, Tran C, James D, Seto T, Shikuma C, Kuwada SK. Ethnic disparities in metabolic dysfunction-associated steatotic liver disease and clinical outcomes. Front Endocrinol (Lausanne). 2025; 16:1739137.

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Saleem S, Sajid MS, Varghese RS, Sherif ZA, Kroemer A, Ressom HW. Phosphopeptidome Profiling of Human Plasma for Hepatocellular Carcinoma Biomarker Discovery. J Proteome Res. 2026 Feb 06; 25(2):1115-1125.

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Nara A, Shimada S, Akiyama Y, Hatano M, Chino Y, Miyazawa S, Tamura H, Asano D, Ishikawa Y, Ueda H, Watanabe S, Katsuta E, Akahoshi K, Ohashi K, Tanabe M, Ban D, Tanaka S. Targeting SPP1-CD44-Hedgehog Axis Elicits Therapeutic Effects in Hepatocellular Carcinoma by Suppressing Intratumoral Fibrosis. Cancer Sci. 2026 Mar; 117(3):670-682.

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He AR, Smith CI, Cruz-Correa M, Chakraborty R, Zhang S, Sang S, Cheng G, Hecht SS, Bazzi LA, Kocherginsky M, Benante KA, Schering T, Richmond E, Rodriguez LM, Khan SA, Chung FL. A Phase I Dose-Escalation Study of Polyphenon E in Liver Cirrhosis: Evaluation of Safety and Effect on Liver ?-OHPdG Levels. Cancer Prev Res (Phila). 2025 Oct 01; 18(10):635-646.

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Li XJ, Chang L, Mi Y, Zhang G, Zhu SS, Zhang YX, Wang HY, Lu YS, Ping YX, Zheng PY, Xue X. Integrated-omics analysis defines subtypes of hepatocellular carcinoma based on circadian rhythm. J Integr Med. 2025 07; 23(4):445-456.

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Wong LL, Hromalik LR, Hernandez BY, Acoba JD, Kwee SA. The Changing Pathogenesis of Liver Cancer in Hawaii over Three Decades. Cancer Epidemiol Biomarkers Prev. 2025 Apr 03; 34(4):527-533.

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Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S. ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T?cells in hepatocellular carcinoma. Cell Rep Med. 2025 Apr 15; 6(4):102038.

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Taniai T, Shimada S, Akiyama Y, Hatano M, Yasukawa K, Igarashi Y, Tsukihara S, Tanji Y, Kodera K, Okazaki K, Haruki K, Nara A, Yagi K, Akahoshi K, Ban D, Asahina Y, Ikegami T, Tanabe M, Tanaka S. Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular HCC. Hepatology. 2026 Feb 01; 83(2):231-248.

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Li T, Song X, Chen J, Li Y, Lin J, Li P, Yu S, Durojaye OA, Yang F, Liu X, Li J, Cheng S, Yao X, Ding X. Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway. Int J Biol Sci. 2025; 21(1):285-305.

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