Type III intermediate filament proteins that assemble into neurofilaments, the major cytoskeletal element in nerve axons and dendrites. They consist of three distinct polypeptides, the neurofilament triplet. Types I, II, and IV intermediate filament proteins form other cytoskeletal elements such as keratins and lamins. It appears that the metabolism of neurofilaments is disturbed in Alzheimer's disease, as indicated by the presence of neurofilament epitopes in the neurofibrillary tangles, as well as by the severe reduction of the expression of the gene for the light neurofilament subunit of the neurofilament triplet in brains of Alzheimer's patients. (Can J Neurol Sci 1990 Aug;17(3):302)

Descriptor ID	D016900
MeSH Number(s)	D05.750.078.593.630 D12.776.220.475.630 D12.776.631.630
Concept/Terms	Neurofilament Proteins Neurofilament Proteins Proteins, Neurofilament Neurofilament Triplet Proteins Neurofilament Triplet Proteins Proteins, Neurofilament Triplet Triplet Proteins, Neurofilament Heavy Neurofilament Protein Heavy Neurofilament Protein Neurofilament Protein, Heavy Protein, Heavy Neurofilament

Below are MeSH descriptors whose meaning is more general than "Neurofilament Proteins".

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Below are MeSH descriptors whose meaning is more specific than "Neurofilament Proteins".