tau Proteins

"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).

Descriptor ID	D016875
MeSH Number(s)	D12.776.220.600.450.510 D12.776.631.560.510
Concept/Terms	tau Proteins tau Proteins Proteins, tau tau Protein Protein, tau

Below are MeSH descriptors whose meaning is more general than "tau Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Cytoskeletal Proteins [D12.776.220]
Microtubule Proteins [D12.776.220.600]
Microtubule-Associated Proteins [D12.776.220.600.450]
tau Proteins [D12.776.220.600.450.510]
Nerve Tissue Proteins [D12.776.631]
Microtubule-Associated Proteins [D12.776.631.560]
tau Proteins [D12.776.631.560.510]

Below are MeSH descriptors whose meaning is related to "tau Proteins".

Below are MeSH descriptors whose meaning is more specific than "tau Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "tau Proteins" by people in this website by year, and whether "tau Proteins" was a major or minor topic of these publications.

Bar chart showing 143 publications over 29 distinct years, with a maximum of 10 publications in 2020

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	1	3	4
1996	1	0	1
1997	0	1	1
1998	1	2	3
1999	0	1	1
2000	4	2	6
2001	0	1	1
2002	4	1	5
2003	3	2	5
2004	3	3	6
2005	4	3	7
2006	2	6	8
2007	2	3	5
2008	5	3	8
2009	4	2	6
2010	3	4	7
2011	2	2	4
2012	2	1	3
2013	4	1	5
2014	1	1	2
2015	2	4	6
2016	6	2	8
2017	5	0	5
2018	5	3	8
2019	3	2	5
2020	5	5	10
2021	3	3	6
2022	1	0	1
2023	3	3	6

Below are the most recent publications written about "tau Proteins" by people in Profiles.

H?ilund-Carlsen PF, Alavi A, Barrio JR, Castellani RJ, Costa T, Herrup K, Kepp KP, Neve RL, Perry G, Revheim ME, Robakis NK, Sensi SL, Vissel B. Revision of Alzheimer's diagnostic criteria or relocation of the Potemkin village. Ageing Res Rev. 2024 Jan; 93:102173.

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Iwaide S, Nakayama Y, Chambers JK, Uchida K, Nakagawa D, Yamanashi Y, Bando H, Murakami T. Senile plaques and phosphorylated tau deposition in a super-aged rhesus monkey (Macaca mulatta). J Vet Med Sci. 2023 Dec 06; 85(12):1296-1300.

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Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on a-Synuclein and Tau Aggregation. ACS Chem Neurosci. 2023 11 01; 14(21):3913-3927.

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Alonso ADC, El Idrissi A, Candia R, Morozova V, Kleiman FE. Tau: More than a microtubule-binding protein in neurons. Cytoskeleton (Hoboken). 2024 Jan; 81(1):71-77.

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Wu T, Deger JM, Ye H, Guo C, Dhindsa J, Pekarek BT, Al-Ouran R, Liu Z, Al-Ramahi I, Botas J, Shulman JM. Tau polarizes an aging transcriptional signature to excitatory neurons and glia. Elife. 2023 May 23; 12.

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Avila J, Perry G. Memory, Sleep, and Tau Function. J Alzheimers Dis. 2023; 94(2):491-495.

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Xolalpa-Cueva L, Garc?a-Carlos CA, Villase?or-Zepeda R, Orta-Salazar E, D?az-Cintra S, Pe?a-Ortega F, Perry G, Mondrag?n-Rodr?guez S. Hyperphosphorylated Tau Relates to Improved Cognitive Performance and Reduced Hippocampal Excitability in the Young rTg4510 Mouse Model of Tauopathy. J Alzheimers Dis. 2022; 87(2):529-543.

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Pushkarsky T, Ward A, Ivanov A, Lin X, Sviridov D, Nekhai S, Bukrinsky MI. Abundance of Nef and p-Tau217 in Brains of Individuals Diagnosed with HIV-Associated Neurocognitive Disorders Correlate with Disease Severance. Mol Neurobiol. 2022 Feb; 59(2):1088-1097.

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Mahdiabadi S, Momtazmanesh S, Perry G, Rezaei N. Immune modulations and immunotherapies for Alzheimer's disease: a comprehensive review. Rev Neurosci. 2022 06 27; 33(4):365-381.

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Hampel H, Hardy J, Blennow K, Chen C, Perry G, Kim SH, Villemagne VL, Aisen P, Vendruscolo M, Iwatsubo T, Masters CL, Cho M, Lannfelt L, Cummings JL, Vergallo A. The Amyloid-? Pathway in Alzheimer's Disease. Mol Psychiatry. 2021 10; 26(10):5481-5503.

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