"4-Butyrolactone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.
| Descriptor ID |
D015107
|
| MeSH Number(s) |
D02.540.150 D03.383.312.150
|
| Concept/Terms |
4-Butyrolactone- 4-Butyrolactone
- 4 Butyrolactone
- Dihydro-2(3H)-furanone
- gamma-Butyrolactone
- gamma Butyrolactone
- Furanone, tetrahydro-2-
- Furanone, tetrahydro 2
- 1,4-Butanolide
- 1,4 Butanolide
- 4-Hydroxybutyric Acid Lactone
- 4 Hydroxybutyric Acid Lactone
- Lactone, 4-Hydroxybutyric Acid
|
Below are MeSH descriptors whose meaning is more general than "4-Butyrolactone".
Below are MeSH descriptors whose meaning is more specific than "4-Butyrolactone".
This graph shows the total number of publications written about "4-Butyrolactone" by people in this website by year, and whether "4-Butyrolactone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 1 | 0 | 1 |
| 2009 | 0 | 1 | 1 |
| 2013 | 1 | 0 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 2 | 1 | 3 |
| 2016 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
| 2022 | 0 | 2 | 2 |
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Below are the most recent publications written about "4-Butyrolactone" by people in Profiles.
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Gonzalez Periche P, Ramdular A, Bhupathiraju NVSDK, Kalidindi T, Johnson DS, Pillarsetty N, Mootoo DR. Synthesis of carbohydrate analogues of the THF-acetogenin 4-deoxyannomontacin and their cytotoxicity against human prostate cancer cell lines. Carbohydr Res. 2022 Nov; 521:108671.
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Rana S, Kour S, Kizhake S, King HM, Mallareddy JR, Case AJ, Huxford T, Natarajan A. Dimers of isatin derived a-methylene-?-butyrolactone as potent anti-cancer agents. Bioorg Med Chem Lett. 2022 06 01; 65:128713.
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Liu G, Li J, Li Y, Hu Y, Franke AA, Liang L, Hu FB, Chan AT, Mukamal KJ, Rimm EB, Sun Q. Gut microbiota-derived metabolites and risk of coronary artery disease: a prospective study among US men and women. Am J Clin Nutr. 2021 07 01; 114(1):238-247.
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Rochford K, Chen F, Waguespack Y, Figliozzi RW, Kharel MK, Zhang Q, Martin-Caraballo M, Hsia SV. Volatile Organic Compound Gamma-Butyrolactone Released upon Herpes Simplex Virus Type -1 Acute Infection Modulated Membrane Potential and Repressed Viral Infection in Human Neuron-Like Cells. PLoS One. 2016; 11(8):e0161119.
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Hu Y, Song Y, Franke AA, Hu FB, van Dam RM, Sun Q. A Prospective Investigation of the Association Between Urinary Excretion of Dietary Lignan Metabolites and Weight Change in US Women. Am J Epidemiol. 2015 Sep 15; 182(6):503-11.
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Zhou Z, Walleser PM, Tius MA. Isotetronic acids from an oxidative cyclization. Chem Commun (Camb). 2015 Jul 11; 51(54):10858-60.
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Miller CM, Benneche T, Tius MA. First total synthesis of the marine natural products clavulolactones II and III. Org Biomol Chem. 2015 Apr 07; 13(13):4051-8.
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Sun Q, Wedick NM, Pan A, Townsend MK, Cassidy A, Franke AA, Rimm EB, Hu FB, van Dam RM. Gut microbiota metabolites of dietary lignans and risk of type 2 diabetes: a prospective investigation in two cohorts of U.S. women. Diabetes Care. 2014; 37(5):1287-95.
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Chorna NE, Santos-Soto IJ, Carballeira NM, Morales JL, de la Nuez J, C?tala-Valentin A, Chornyy AP, V?zquez-Montes A, De Ortiz SP. Fatty acid synthase as a factor required for exercise-induced cognitive enhancement and dentate gyrus cellular proliferation. PLoS One. 2013; 8(11):e77845.
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Xie J, Tworoger SS, Franke AA, Terry KL, Rice MS, Rosner BA, Willett WC, Hankinson SE, Eliassen AH. Plasma enterolactone and breast cancer risk in the Nurses' Health Study II. Breast Cancer Res Treat. 2013 Jun; 139(3):801-9.