"Tryptophan Hydroxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
| Descriptor ID |
D014365
|
| MeSH Number(s) |
D08.811.682.690.708.870
|
| Concept/Terms |
Tryptophan Hydroxylase- Tryptophan Hydroxylase
- Hydroxylase, Tryptophan
- Tryptophan Monooxygenase
- Monooxygenase, Tryptophan
|
Below are MeSH descriptors whose meaning is more general than "Tryptophan Hydroxylase".
Below are MeSH descriptors whose meaning is more specific than "Tryptophan Hydroxylase".
This graph shows the total number of publications written about "Tryptophan Hydroxylase" by people in this website by year, and whether "Tryptophan Hydroxylase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tryptophan Hydroxylase" by people in Profiles.
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Cheng HH, Chu LY, Chiang LY, Chen HL, Kuo CC, Wu KK. Inhibition of cancer cell epithelial mesenchymal transition by normal fibroblasts via production of 5-methoxytryptophan. Oncotarget. 2016 May 24; 7(21):31243-56.
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Hwa LS, Shimamoto A, Kayyali T, Norman KJ, Valentino RJ, DeBold JF, Miczek KA. Dissociation of ?-opioid receptor and CRF-R1 antagonist effects on escalated ethanol consumption and mPFC serotonin in C57BL/6J mice. Addict Biol. 2016 Jan; 21(1):111-24.
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Cheng HH, Kuo CC, Yan JL, Chen HL, Lin WC, Wang KH, Tsai KK, Guv?n H, Flaberg E, Szekely L, Klein G, Wu KK. Control of cyclooxygenase-2 expression and tumorigenesis by endogenous 5-methoxytryptophan. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13231-6.
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Liang J, Wessel JH, Iuvone PM, Tosini G, Fukuhara C. Diurnal rhythms of tryptophan hydroxylase 1 and 2 mRNA expression in the rat retina. Neuroreport. 2004 Jun 28; 15(9):1497-500.
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Alves SE, Hoskin E, Lee SJ, Brake WG, Ferguson D, Luine V, Allen PB, Greengard P, McEwen BS. Serotonin mediates CA1 spine density but is not crucial for ovarian steroid regulation of synaptic plasticity in the adult rat dorsal hippocampus. Synapse. 2002 Aug; 45(2):143-51.