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Clivel Charlton
Title Chair
Faculty Rank Professor
Degree Ph.D.
Institution Meharry Medical College
Department Neuroscience and Pharmacology
Clusters Infectious and Immunological Diseases
Address
1005 Dr. D. B. Todd Blvd
City Nashville
State TN
Postal Code 37208
Telephone 615.327.6971
Fax
Email
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1. Charlton CG. Methylation reactions at dopaminergic nerve endings, serving as biological off-switches in managing dopaminergic functions. Neural Regen Res. 2014 Jun 01; 9(11):1110-1.
2. Smith ML, King J, Dent L, Mackey V, Muthian G, Griffin B, Charlton CG. Effects of acute and sub-chronic L-dopa therapy on striatal L-dopa methylation and dopamine oxidation in an MPTP mouse model of Parkinsons disease. Life Sci. 2014 Aug 06; 110(1):1-7.
3. Mackey VR, Muthian G, Smith M, King J, Charlton CG. Prenatal exposure to methanol as a dopamine system sensitization model in C57BL/6J mice. Life Sci. 2012 Nov 02; 91(19-20):921-7.
4. King JM, Muthian G, Mackey V, Smith M, Charlton C. L-Dihydroxyphenylalanine modulates the steady-state expression of mouse striatal tyrosine hydroxylase, aromatic L-amino acid decarboxylase, dopamine and its metabolites in an MPTP mouse model of Parkinson's disease. Life Sci. 2011 Oct 24; 89(17-18):638-43.
5. Muthian G, Mackey V, King J, Charlton CG. Modeling a sensitization stage and a precipitation stage for Parkinson's disease using prenatal and postnatal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. Neuroscience. 2010 Sep 01; 169(3):1085-93.
6. Lee ES, Chen H, Hardman C, Simm A, Charlton C. Excessive S-adenosyl-L-methionine-dependent methylation increases levels of methanol, formaldehyde and formic acid in rat brain striatal homogenates: possible role in S-adenosyl-L-methionine-induced Parkinson's disease-like disorders. Life Sci. 2008 Dec 19; 83(25-26):821-7.
7. Lee ES, Chen H, King J, Charlton C. The role of 3-O-methyldopa in the side effects of L-dopa. Neurochem Res. 2008 Mar; 33(3):401-11.
8. Shepherd KR, Lee ES, Schmued L, Jiao Y, Ali SF, Oriaku ET, Lamango NS, Soliman KF, Charlton CG. The potentiating effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on paraquat-induced neurochemical and behavioral changes in mice. Pharmacol Biochem Behav. 2006 Mar; 83(3):349-59.
9. Lee ES, Chen H, Charlton CG, Soliman KF. The role of phospholipid methylation in 1-methyl-4-phenyl-pyridinium ion (MPP+)-induced neurotoxicity in PC12 cells. Neurotoxicology. 2005 Dec; 26(6):945-57.
10. Lee ES, Chen H, Soliman KF, Charlton CG. Effects of homocysteine on the dopaminergic system and behavior in rodents. Neurotoxicology. 2005 Jun; 26(3):361-71.
11. Lee ES, Soliman KF, Charlton CG. Lysophosphatidylcholine decreases locomotor activities and dopamine turnover rate in rats. Neurotoxicology. 2005 Jan; 26(1):27-38.
12. Kim JS, Coon SL, Blackshaw S, Cepko CL, Møller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005 Jan 07; 280(1):677-84.
13. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. Inhibitory effects of lysophosphatidylcholine on the dopaminergic system. Neurochem Res. 2004 Jul; 29(7):1333-42.
14. Lee ES, Chen H, Shepherd KR, Lamango NS, Soliman KF, Charlton CG. The inhibitory role of methylation on the binding characteristics of dopamine receptors and transporter. Neurosci Res. 2004 Mar; 48(3):335-44.
15. Lamango NS, Ayuk-Takem LT, Nesby R, Zhao WQ, Charlton CG. Inhibition mechanism of S-adenosylmethionine-induced movement deficits by prenylcysteine analogs. Pharmacol Biochem Behav. 2003 Dec; 76(3-4):433-42.
16. Zhao WQ, Williams Z, Shepherd KR, Reuben JS, Lee ES, Darling-Reed S, Lamango N, Soliman KF, Charlton CG. S-adenosyl-methionine-induced apoptosis in PC12 cells. J Neurosci Res. 2002 Aug 15; 69(4):519-29.
17. Zhao WQ, Latinwo L, Liu XX, Lee ES, Lamango N, Charlton CG. L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase. Exp Neurol. 2001 Sep; 171(1):127-38.
18. Lee ES, Charlton CG. 1-Methyl-4-phenyl-pyridinium increases S-adenosyl-L-methionine dependent phospholipid methylation. Pharmacol Biochem Behav. 2001 Sep; 70(1):105-14.
19. Lamango NS, Charlton CG. Farnesyl-L-cysteine analogs block SAM-induced Parkinson's disease-like symptoms in rats. Pharmacol Biochem Behav. 2000 Aug; 66(4):841-9.
20. Charlton CG, Crowell B. Effects of dopamine metabolites on locomotor activities and on the binding of dopamine: relevance to the side effects of L-dopa. Life Sci. 2000 Apr 21; 66(22):2159-71.
21. Lamango NS, Nesby RA, Charlton CG. Quantification of S-adenosylmethionine-induced tremors: a possible tremor model for Parkinson's disease. Pharmacol Biochem Behav. 2000 Mar; 65(3):523-9.
22. Liu XX, Wilson K, Charlton CG. Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa. Life Sci. 2000; 66(23):2277-88.
23. Charlton CG. Depletion of nigrostriatal and forebrain tyrosine hydroxylase by S-adenosylmethionine: a model that may explain the occurrence of depression in Parkinson's disease. Life Sci. 1997; 61(5):495-502.
24. Charlton CG, Crowell B. Striatal dopamine depletion, tremors, and hypokinesia following the intracranial injection of S-adenosylmethionine: a possible role of hypermethylation in parkinsonism. Mol Chem Neuropathol. 1995 Dec; 26(3):269-84.
25. Charlton CG, Mack J. Substantia nigra degeneration and tyrosine hydroxylase depletion caused by excess S-adenosylmethionine in the rat brain. Support for an excess methylation hypothesis for parkinsonism. Mol Neurobiol. 1994 Aug-Dec; 9(1-3):149-61.
26. Crowell BG, Benson R, Shockley D, Charlton CG. S-adenosyl-L-methionine decreases motor activity in the rat: similarity to Parkinson's disease-like symptoms. Behav Neural Biol. 1993 May; 59(3):186-93.
27. Benson R, Crowell B, Hill B, Doonquah K, Charlton C. The effects of L-dopa on the activity of methionine adenosyltransferase: relevance to L-dopa therapy and tolerance. Neurochem Res. 1993 Mar; 18(3):325-30.
28. Charlton CG, Crowell B. Parkinson's disease-like effects of S-adenosyl-L-methionine: effects of L-dopa. Pharmacol Biochem Behav. 1992 Oct; 43(2):423-31.
29. Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992 Apr-Jun; 5(2):114-8.
30. Charlton CG, Crowell B, Benson R. Identification of motor neurons for accessory muscles of inspiration and expiration, pectoralis, trapezius and external oblique: comparison with non-respiratory skeletal muscle. Synapse. 1988; 2(3):219-24.
31. Helke CJ, Charlton CG, Wiley RG. Studies on the cellular localization of spinal cord substance P receptors. Neuroscience. 1986 Oct; 19(2):523-33.
32. Charlton CG, Helke CJ. Autoradiographic localization and characterization of spinal cord substance P binding sites: high densities in sensory, autonomic, phrenic, and Onuf's motor nuclei. J Neurosci. 1985 Jun; 5(6):1653-61.
33. Helke CJ, Charlton CG, Wiley RG. Suicide transport of ricin demonstrates the presence of substance P receptors on medullary somatic and autonomic motor neurons. Brain Res. 1985 Feb 25; 328(1):190-5.
34. Charlton CG, Miller RL, Crawley JN, Handelmann GE, O'Donohue TL. Secretin modulation of behavioral and physiological functions in the rat. Peptides. 1983 Sep-Oct; 4(5):739-42.
35. O'Donohue TL, Charlton CG, Miller RL, Boden G, Jacobowitz DM. Identification, characterization, and distribution of secretin immunoreactivity in rat and pig brain. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):5221-4.
36. Charlton CG, O'Donohue TL, Miller RL, Jacobowitz DM. Secretin immunoreactivity in rat and pig brain. Peptides. 1981; 2 Suppl 1:45-9.
37. Charlton CG, Way EL. Tremor induced by S-adenosyl-L-methionine: possible relation to L-dopa effects. J Pharm Pharmacol. 1978 Dec; 30(12):819-20.

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Keywords
Dopamine
S-Adenosylmethionine
Levodopa
Parkinson Disease
Antiparkinson Agents
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