"S-Adenosylmethionine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)
| Descriptor ID |
D012436
|
| MeSH Number(s) |
D02.886.030.676.180 D03.633.100.759.590.138.264 D12.125.166.676.180 D13.570.583.138.264 D13.570.800.096.264
|
| Concept/Terms |
S-Adenosylmethionine- S-Adenosylmethionine
- S Adenosylmethionine
- SAM-e
- AdoMet
- S-Adenosyl-L-Methionine
- S Adenosyl L Methionine
- Ademetionine
|
Below are MeSH descriptors whose meaning is more general than "S-Adenosylmethionine".
Below are MeSH descriptors whose meaning is more specific than "S-Adenosylmethionine".
This graph shows the total number of publications written about "S-Adenosylmethionine" by people in this website by year, and whether "S-Adenosylmethionine" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 2000 | 2 | 0 | 2 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2005 | 0 | 2 | 2 |
| 2006 | 0 | 1 | 1 |
| 2008 | 3 | 0 | 3 |
| 2012 | 0 | 1 | 1 |
| 2015 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
| 2018 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 1 | 2 | 3 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "S-Adenosylmethionine" by people in Profiles.
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Chen J, Galv?n AE, Viswanathan T, Yoshinaga M, Rosen BP. Selective Methylation by an ArsM S-Adenosylmethionine Methyltransferase from Burkholderia gladioli GSRB05 Enhances Antibiotic Production. Environ Sci Technol. 2022 10 04; 56(19):13858-13866.
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Li J, Sun C, Cai W, Li J, Rosen BP, Chen J. Insights into S-adenosyl-l-methionine (SAM)-dependent methyltransferase related diseases and genetic polymorphisms. Mutat Res Rev Mutat Res. 2021 Jul-Dec; 788:108396.
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Galv?n AE, Paul NP, Chen J, Yoshinaga-Sakurai K, Utturkar SM, Rosen BP, Yoshinaga M. Identification of the Biosynthetic Gene Cluster for the Organoarsenical Antibiotic Arsinothricin. Microbiol Spectr. 2021 09 03; 9(1):e0050221.
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Yoshinaga-Sakurai K, Rossman TG, Rosen BP. Regulation of arsenic methylation: identification of the transcriptional region of the human AS3MT gene. Cell Biol Toxicol. 2022 10; 38(5):765-780.
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Suzol SH, Hasan Howlader A, Galv?n AE, Radhakrishnan M, Wnuk SF, Rosen BP, Yoshinaga M. Semisynthesis of the Organoarsenical Antibiotic Arsinothricin. J Nat Prod. 2020 09 25; 83(9):2809-2813.
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Packianathan C, Kandavelu P, Rosen BP. The Structure of an As(III) S-Adenosylmethionine Methyltransferase with 3-Coordinately Bound As(III) Depicts the First Step in Catalysis. Biochemistry. 2018 07 17; 57(28):4083-4092.
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Chen J, Li J, Jiang X, Rosen BP. Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase from Aspergillus fumigatus. Mol Microbiol. 2017 04; 104(2):250-259.
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Dong H, Madegowda M, Nefzi A, Houghten RA, Giulianotti MA, Rosen BP. Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT). Chem Res Toxicol. 2015 Dec 21; 28(12):2419-25.
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Dong H, Xu W, Pillai JK, Packianathan C, Rosen BP. High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. Anal Biochem. 2015 Jul 01; 480:67-73.
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Ajees AA, Marapakala K, Packianathan C, Sankaran B, Rosen BP. Structure of an As(III) S-adenosylmethionine methyltransferase: insights into the mechanism of arsenic biotransformation. Biochemistry. 2012 Jul 10; 51(27):5476-85.