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Borza, Dorin-Bogdan
One or more keywords matched the following properties of Borza, Dorin-Bogdan
PropertyValue
keywords type IV collagen
overview My research leverages my multi-disciplinary training in biochemistry, immunology and nephrology to elucidate the molecular mechanisms underlying the etiology and pathogenesis of antibody-mediated glomerular diseases. I have extensive experience and expertise studying the structure, function and pathobiology of type IV collagen and its role in acquired and inherited diseases of the glomerular basement membrane (GBM). I rank among the leading experts in the areas of Goodpasture disease (anti-GBM antibody nephritis) and Alport syndrome. I am also interested in the pathomechanisms of and factors contributing to health disparities in lupus nephritis and membranous nephropathy.
One or more keywords matched the following items that are connected to Borza, Dorin-Bogdan
Item TypeName
Academic Article Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic a3(IV) collagen autoepitopes in vivo.
Academic Article Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
Academic Article Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption.
Academic Article Murine membranous nephropathy: immunization with a3(IV) collagen fragment induces subepithelial immune complexes and Fc?R-independent nephrotic syndrome.
Academic Article Proteolysis breaks tolerance toward intact a345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for a345NC1 hexamers.
Academic Article Quaternary epitopes of a345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.
Academic Article A case of subepidermal blistering disease with autoantibodies to multiple laminin subunits who developed later autoantibodies to alpha-5 chain of type IV collagen associated with membranous glomerulonephropathy.
Academic Article A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.
Academic Article Neonatal Fc receptor promotes immune complex-mediated glomerular disease.
Academic Article IgG4-restricted anti-glomerular basement membrane autoantibodies targeting quaternary epitopes of native a345(IV) collagen.
Academic Article Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways.
Academic Article Glomerular basement membrane heparan sulfate in health and disease: A regulator of local complement activation.
Academic Article Molecular characterization of the target antigens of anti-glomerular basement membrane antibody disease.
Academic Article A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.
Academic Article Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.
Academic Article Recurrent Goodpasture's disease secondary to a monoclonal IgA1-kappa antibody autoreactive with the alpha1/alpha2 chains of type IV collagen.
Academic Article Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesis.
Academic Article Distinct epitopes for anti-glomerular basement membrane alport alloantibodies and goodpasture autoantibodies within the noncollagenous domain of alpha3(IV) collagen: a janus-faced antigen.
Academic Article Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice.
Academic Article Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.
Academic Article The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain.
Academic Article A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.
Academic Article The extracellular matrix of hydra is a porous sheet and contains type IV collagen.
Academic Article Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.
Academic Article Stem cell therapy for Alport syndrome: the hope beyond the hype.
Academic Article Cellular origins of type IV collagen networks in developing glomeruli.
Academic Article Autoepitopes and alloepitopes of type IV collagen: role in the molecular pathogenesis of anti-GBM antibody glomerulonephritis.
Academic Article Maturational changes in laminin, fibronectin, collagen IV, and perlecan in germinal matrix, cortex, and white matter and effect of betamethasone.
Academic Article Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network.
Academic Article Antigenic heterogeneity of IgA anti-GBM disease: new renal targets of IgA autoantibodies.
Concept Collagen
Concept Collagen Type I
Concept Collagen Type IV
Grant Molecular pathogenesis of anti-glomerular basement membrane nephritis
Grant Age-related structural alterations in loss of self-tolerance to a3(IV) collagen
Academic Article The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain.
Academic Article The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain.
Academic Article Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains.
Academic Article Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitope.
Academic Article The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes.
Academic Article Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.
Academic Article Laminin-521 is a Novel Target of Autoantibodies Associated with Lung Hemorrhage in Anti-GBM Disease.
Academic Article Editorial: Collagen IV nephropathies: Alport syndrome and beyond.
Search Criteria
  • Collagen
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