A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.

Heidet L, Borza DB, Jouin M, Sich M, Mattei MG, Sado Y, Hudson BG, Hastie N, Antignac C, Gubler MC. A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice. Am J Pathol. 2003 Oct; 163(4):1633-44.

View in: PubMed

subject areas

Animals
Autoantibodies
Autoantigens
Basement Membrane
Chimera
Collagen Type IV
Extracellular Matrix Proteins
Humans
Kidney
Mice
Mice, Knockout
Mice, Transgenic
Nephritis, Hereditary
Phenotype
Protein Isoforms
Protein Subunits
RNA, Messenger

authors with profiles

Dorin-Bogdan Borza

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support