Nephritis, Hereditary

"Nephritis, Hereditary" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.

Descriptor ID	D009394
MeSH Number(s)	C12.706.742 C12.777.419.570.620 C13.351.875.742 C13.351.968.419.570.620 C16.131.939.742 C17.300.200.517
Concept/Terms	Nephritis, Hereditary Nephritis, Hereditary Hereditary Nephritis Nephritis, Familial Familial Nephritis Hereditary Interstitial Pyelonephritis Pyelonephritis, Hereditary Interstitial Hemorrhagic Hereditary Nephritis Hemorrhagic Hereditary Nephritis Nephritis, Hemorrhagic Hereditary Hemorrhagic Familial Nephritis Nephritis, Hemorrhagic Familial Hereditary Hematuria Syndrome Congenital Hereditary Hematuria Hematuria, Congenital Hereditary Hematuric Hereditary Nephritis Nephritis, Hematuric Hereditary Hereditary Familial Congenital Hemorrhagic Nephritis Alport Syndrome, Autosomal Recessive Alport Syndrome, Autosomal Recessive Alport Syndrome, X-Linked Alport Syndrome, X-Linked Alport Syndrome, X Linked X-Linked Alport Syndrome Alport Syndrome Alport Syndrome Syndrome, Alport Hematuria-Nephropathy-Deafness Syndrome Hematuria Nephropathy Deafness Syndrome Syndrome, Hematuria-Nephropathy-Deafness Alport's Syndrome Alport Syndrome, Autosomal Dominant Alport Syndrome, Autosomal Dominant

Below are MeSH descriptors whose meaning is more general than "Nephritis, Hereditary".

Diseases [C]
Male Urogenital Diseases [C12]
Urogenital Abnormalities [C12.706]
Nephritis, Hereditary [C12.706.742]
Urologic Diseases [C12.777]
Kidney Diseases [C12.777.419]
Nephritis [C12.777.419.570]
Nephritis, Hereditary [C12.777.419.570.620]
Female Urogenital Diseases and Pregnancy Complications [C13]
Female Urogenital Diseases [C13.351]
Urogenital Abnormalities [C13.351.875]
Nephritis, Hereditary [C13.351.875.742]
Urologic Diseases [C13.351.968]
Kidney Diseases [C13.351.968.419]
Nephritis [C13.351.968.419.570]
Nephritis, Hereditary [C13.351.968.419.570.620]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Urogenital Abnormalities [C16.131.939]
Nephritis, Hereditary [C16.131.939.742]
Skin and Connective Tissue Diseases [C17]
Connective Tissue Diseases [C17.300]
Collagen Diseases [C17.300.200]
Nephritis, Hereditary [C17.300.200.517]

Below are MeSH descriptors whose meaning is more specific than "Nephritis, Hereditary".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Nephritis, Hereditary" by people in this website by year, and whether "Nephritis, Hereditary" was a major or minor topic of these publications.

Bar chart showing 14 publications over 11 distinct years, with a maximum of 2 publications in 2007 and 2008 and 2010

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2000	0	1	1
2001	0	1	1
2003	1	0	1
2005	0	1	1
2006	1	0	1
2007	2	0	2
2008	2	0	2
2009	0	1	1
2010	2	0	2
2013	1	0	1
2014	1	0	1

Below are the most recent publications written about "Nephritis, Hereditary" by people in Profiles.

Gomez IG, MacKenna DA, Johnson BG, Kaimal V, Roach AM, Ren S, Nakagawa N, Xin C, Newitt R, Pandya S, Xia TH, Liu X, Borza DB, Grafals M, Shankland SJ, Himmelfarb J, Portilla D, Liu S, Chau BN, Duffield JS. Anti-microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways. J Clin Invest. 2015 Jan; 125(1):141-56.

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Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB. Quaternary epitopes of a345(IV) collagen initiate Alport post-transplant anti-GBM nephritis. J Am Soc Nephrol. 2013 May; 24(6):889-95.

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Luo W, Wang XP, Kashtan CE, Borza DB. Alport alloantibodies but not Goodpasture autoantibodies induce murine glomerulonephritis: protection by quinary crosslinks locking cryptic a3(IV) collagen autoepitopes in vivo. J Immunol. 2010 Sep 15; 185(6):3520-8.

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Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis. N Engl J Med. 2010 Jul 22; 363(4):343-54.

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Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL. Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol. 2009 Jul; 20(7):1471-9.

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Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson DR, Antignac C, Tryggvason K, Hudson B, Miner JH. Stem cell therapy for Alport syndrome: the hope beyond the hype. Nephrol Dial Transplant. 2009 Mar; 24(3):731-4.

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Kang JS, Colon S, Hellmark T, Sado Y, Hudson BG, Borza DB. Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy. J Biol Chem. 2008 Dec 12; 283(50):35070-7.

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Kang JS, Kashtan CE, Turner AN, Heidet L, Hudson BG, Borza DB. The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain. J Biol Chem. 2007 Apr 06; 282(14):10670-7.

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Cosgrove D, Kalluri R, Miner JH, Segal Y, Borza DB. Choosing a mouse model to study the molecular pathobiology of Alport glomerulonephritis. Kidney Int. 2007 Apr; 71(7):615-8.

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Kang JS, Wang XP, Miner JH, Morello R, Sado Y, Abrahamson DR, Borza DB. Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice. J Am Soc Nephrol. 2006 Jul; 17(7):1962-9.

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