Proteolysis breaks tolerance toward intact a345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for a345NC1 hexamers.
Olaru F, Wang XP, Luo W, Ge L, Miner JH, Kleinau S, Geiger XJ, Wasiluk A, Heidet L, Kitching AR, Borza DB. Proteolysis breaks tolerance toward intact a345(IV) collagen, eliciting novel anti-glomerular basement membrane autoantibodies specific for a345NC1 hexamers. J Immunol. 2013 Feb 15; 190(4):1424-32.