Apolipoprotein E4

"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

Descriptor ID	D053327
MeSH Number(s)	D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
Concept/Terms	Apolipoprotein E4 Apolipoprotein E4 Apolipoprotein E-4 Apolipoprotein E 4 Apo E4 ApoE4 Apo E epsilon 4 Apo E-4 Apo E 4

Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".

Chemicals and Drugs [D]
Lipids [D10]
Lipoproteins [D10.532]
Apolipoproteins [D10.532.091]
Apolipoproteins E [D10.532.091.500]
Apolipoprotein E4 [D10.532.091.500.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Apoproteins [D12.776.070]
Apolipoproteins [D12.776.070.400]
Apolipoproteins E [D12.776.070.400.500]
Apolipoprotein E4 [D12.776.070.400.500.750]
Lipoproteins [D12.776.521]
Apolipoproteins [D12.776.521.120]
Apolipoproteins E [D12.776.521.120.500]
Apolipoprotein E4 [D12.776.521.120.500.750]

Below are MeSH descriptors whose meaning is related to "Apolipoprotein E4".

Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.

Bar chart showing 35 publications over 15 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	1	1
2004	0	1	1
2007	1	4	5
2008	2	1	3
2010	1	3	4
2011	0	1	1
2012	3	0	3
2013	2	1	3
2014	1	0	1
2016	3	1	4
2017	1	0	1
2018	4	0	4
2020	0	1	1
2022	1	1	2
2024	0	1	1

Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.

Park SY, Setiawan VW, Crimmins EM, White LR, Wu AH, Cheng I, Darst BF, Haiman CA, Wilkens LR, Le Marchand L, Lim U. Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias. Neurology. 2024 Feb 13; 102(3):e208116.

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Margrett JA, Schofield T, Martin P, Poon LW, Masaki K, Donlon TA, Kallianpur KJ, Willcox BJ. Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1525-1533.

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Shen B, Hernandez DG, Chitrala KN, Fanelli-Kuczmarski MT, Noren Hooten N, Pacheco NL, Mode NA, Zonderman AB, Ezike N, Evans MK. APOE gene region methylation is associated with cognitive performance in middle-aged urban adults. Neurobiol Aging. 2022 08; 116:41-48.

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Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. 2020 06 03; 106(5):727-742.e6.

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Rajabli F, Feliciano BE, Celis K, Hamilton-Nelson KL, Whitehead PL, Adams LD, Bussies PL, Manrique CP, Rodriguez A, Rodriguez V, Starks T, Byfield GE, Sierra Lopez CB, McCauley JL, Acosta H, Chinea A, Kunkle BW, Reitz C, Farrer LA, Schellenberg GD, Vardarajan BN, Vance JM, Cuccaro ML, Martin ER, Haines JL, Byrd GS, Beecham GW, Pericak-Vance MA. Ancestral origin of ApoE e4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet. 2018 12; 14(12):e1007791.

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Burke SL, Hu T, Spadola CE, Li T, Naseh M, Burgess A, Cadet T. Mild cognitive impairment: associations with sleep disturbance, apolipoprotein e4, and sleep medications. Sleep Med. 2018 12; 52:168-176.

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Burke SL, Hu T, Spadola CE, Burgess A, Li T, Cadet T. Treatment of Sleep Disturbance May Reduce the Risk of Future Probable Alzheimer's Disease. J Aging Health. 2019 02; 31(2):322-342.

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Frank L, Wesson Ashford J, Bayley PJ, Borson S, Buschke H, Cohen D, Cummings JL, Davies P, Dean M, Finkel SI, Hyer L, Perry G, Powers RE, Schmitt F. Genetic Risk of Alzheimer's Disease: Three Wishes Now That the Genie is Out of the Bottle. J Alzheimers Dis. 2018; 66(2):421-423.

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Burke SL, Maramaldi P, Cadet T, Kukull W. Decreasing hazards of Alzheimer's disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry. 2018 Jan; 33(1):200-211.

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Allard JS, Ntekim O, Johnson SP, Ngwa JS, Bond V, Pinder D, Gillum RF, Fungwe TV, Kwagyan J, Obisesan TO. APOEe4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study. Exp Gerontol. 2017 01; 87(Pt A):129-136.

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