Apolipoprotein E4

"Apolipoprotein E4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A major and the second most common isoform of apolipoprotein E. In humans, Apo E4 differs from APOLIPOPROTEIN E3 at only one residue 112 (cysteine is replaced by arginine), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for ALZHEIMER DISEASE and CARDIOVASCULAR DISEASES.

Descriptor ID	D053327
MeSH Number(s)	D10.532.091.500.750 D12.776.070.400.500.750 D12.776.521.120.500.750
Concept/Terms	Apolipoprotein E4 Apolipoprotein E4 Apolipoprotein E-4 Apolipoprotein E 4 Apo E4 ApoE4 Apo E epsilon 4 Apo E-4 Apo E 4

Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E4".

Chemicals and Drugs [D]
Lipids [D10]
Lipoproteins [D10.532]
Apolipoproteins [D10.532.091]
Apolipoproteins E [D10.532.091.500]
Apolipoprotein E4 [D10.532.091.500.750]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Apoproteins [D12.776.070]
Apolipoproteins [D12.776.070.400]
Apolipoproteins E [D12.776.070.400.500]
Apolipoprotein E4 [D12.776.070.400.500.750]
Lipoproteins [D12.776.521]
Apolipoproteins [D12.776.521.120]
Apolipoproteins E [D12.776.521.120.500]
Apolipoprotein E4 [D12.776.521.120.500.750]

Below are MeSH descriptors whose meaning is related to "Apolipoprotein E4".

Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E4".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Apolipoprotein E4" by people in this website by year, and whether "Apolipoprotein E4" was a major or minor topic of these publications.

Bar chart showing 42 publications over 15 distinct years, with a maximum of 5 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2007	1	4	5
2008	3	1	4
2010	1	3	4
2011	0	1	1
2012	3	0	3
2013	2	1	3
2014	1	0	1
2016	3	1	4
2017	2	0	2
2018	4	0	4
2020	0	1	1
2022	1	2	3
2024	2	1	3
2025	2	1	3

Below are the most recent publications written about "Apolipoprotein E4" by people in Profiles.

Dorfsman DA, Cai D, Hamilton-Nelson KL, Adams LD, Mena PR, Rodriguez VC, Sanchez JJ, Valladares GS, Lopez M, Whitehead PL, Prough MB, Manrique P, Martinez A, Mas SM, Scaramutti C, Acosta H, Silva-Vergara C, McInerney K, Griswold AJ, Feliciano-Astacio BE, Cuccaro ML, Kunkle BW, Reitz C, Tosto G, Bush WS, Haines JL, Akinyemi JO, Akinyemi RO, Ogunniyi A, Byrd GS, Vance JM, Celis K, Seixas A, Pericak-Vance MA, Rajabli F. Educational attainment is associated with reduced functional decline in Puerto Ricans with elevated pTau181. J Alzheimers Dis. 2026 Mar; 110(2):685-695.

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Anthony M, Xie Y, O'Neil JN, Teng S. Structural Analysis of Missense Mutations on the Stability of APOE3 and APOE4. Genes (Basel). 2025 Dec 16; 16(12).

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Lee YJ, Masaki KH, Chen R, Martin P, Gonzales E, Whetung C, Takemoto K, Willcox BJ. Active aging activities and genetic determinants of cognitive health: findings from the Kuakini Honolulu-Asia Aging Study. Gerontologist. 2025 09 26; 65(10).

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Burke SL, Grudzien A, Li T, Goulett N, Barnes CP, Hanson K, DeKosky ST. Brain Structures Associated with Depression in Older Adults in the National Alzheimer's Coordinating Center Uniform Data Set. J Geriatr Psychiatry Neurol. 2026 03; 39(2):207-224.

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Meyer-Acosta KK, Diaz-Guerra E, Varma P, Aruk A, Mirsadeghi S, Muniz-Perez A, Rafati Y, Hosseini A, Nieto-Estevez V, Giugliano M, Navara C, Hsieh J. APOE4 impacts cortical neurodevelopment and alters network formation in human brain organoids. Stem Cell Reports. 2025 Jul 08; 20(7):102537.

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Burke SL, Grudzien A, Li T, Garcia S, Martinez SS, Jurich E, Jimenez DR, Hern?ndez J, Liu Q, Tyrell TA, Goulett N, Campa AL, Bursac Z, Baum MK. The influence of socioeconomic factors and apolipoprotein e genotype on cognitive outcomes in a multi-ethnic sample living with HCV and HIV. Int J STD AIDS. 2025 Aug; 36(9):719-730.

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Burke SL, Grudzien A, Li T, Garcia S, Martinez SS, Jurich E, Jimenez DR, Hern?ndez J, Liu Q, Tyrell TA, Campa AL, Johnson A, Bursac Z, Baum MK. Substance use moderates relationships between apolipoprotein E genotype, hepatitis C, cognition, and depression in Miami Adult Studies on HIV (MASH) participants. J Neurovirol. 2024 12; 30(5-6):500-512.

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Neale ZE, Fonda JR, Miller MW, Wolf EJ, Zhang R, Sherva R, Harrington KM, Merritt V, Panizzon MS, Hauger RL, Gaziano JM, Logue MW. Subjective cognitive concerns, APOE e4, PTSD symptoms, and risk for dementia among older veterans. Alzheimers Res Ther. 2024 06 29; 16(1):143.

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Miller MW, Wolf EJ, Zhao X, Logue MW, Hawn SE. An EWAS of dementia biomarkers and their associations with age, African ancestry, and PTSD. Clin Epigenetics. 2024 03 02; 16(1):38.

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Park SY, Setiawan VW, Crimmins EM, White LR, Wu AH, Cheng I, Darst BF, Haiman CA, Wilkens LR, Le Marchand L, Lim U. Racial and Ethnic Differences in the Population-Attributable Fractions of Alzheimer Disease and Related Dementias. Neurology. 2024 Feb 13; 102(3):e208116.

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