"Apolipoprotein E2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
| Descriptor ID |
D053329
|
| MeSH Number(s) |
D10.532.091.500.249 D12.776.070.400.500.249 D12.776.521.120.500.249
|
| Concept/Terms |
Apolipoprotein E2- Apolipoprotein E2
- APOE-epsilon2
- APOE epsilon2
- ApoE2
- APOE-epsilon 2
- APOE epsilon 2
- Apo E-2
- Apo E 2
- Apo E2
- Apolipoprotein E-epsilon2
- Apolipoprotein E epsilon2
- Apolipoprotein E-2
- Apolipoprotein E 2
|
Below are MeSH descriptors whose meaning is more general than "Apolipoprotein E2".
Below are MeSH descriptors whose meaning is more specific than "Apolipoprotein E2".
This graph shows the total number of publications written about "Apolipoprotein E2" by people in this website by year, and whether "Apolipoprotein E2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 0 | 1 |
| 2020 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
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click here.
Below are the most recent publications written about "Apolipoprotein E2" by people in Profiles.
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Margrett JA, Schofield T, Martin P, Poon LW, Masaki K, Donlon TA, Kallianpur KJ, Willcox BJ. Novel Functional, Health, and Genetic Determinants of Cognitive Terminal Decline: Kuakini Honolulu Heart Program/Honolulu-Asia Aging Study. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1525-1533.
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Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi ON, Martens YA, Li Z, Bastea L, Meneses AD, Chen K, Thompson JW, St John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G. Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. Neuron. 2020 06 03; 106(5):727-742.e6.
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Obisesan TO, Umar N, Paluvoi N, Gillum RF. Association of leisure-time physical activity with cognition by apolipoprotein-E genotype in persons aged 60 years and over: the National Health and Nutrition Examination Survey (NHANES-III). Clin Interv Aging. 2012; 7:35-43.
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Logue MW, Schu M, Vardarajan BN, Buros J, Green RC, Go RC, Griffith P, Obisesan TO, Shatz R, Borenstein A, Cupples LA, Lunetta KL, Fallin MD, Baldwin CT, Farrer LA. A comprehensive genetic association study of Alzheimer disease in African Americans. Arch Neurol. 2011 Dec; 68(12):1569-79.