alpha-Synuclein

"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.

Descriptor ID	D051844
MeSH Number(s)	D12.776.631.860.500 D12.776.637.500
Concept/Terms	alpha-Synuclein alpha-Synuclein alpha Synuclein Non-AB Component of AD Amyloid Protein Non AB Component of AD Amyloid Protein

Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Nerve Tissue Proteins [D12.776.631]
Synucleins [D12.776.631.860]
alpha-Synuclein [D12.776.631.860.500]
Parkinson Disease Associated Proteins [D12.776.637]
alpha-Synuclein [D12.776.637.500]

Below are MeSH descriptors whose meaning is related to "alpha-Synuclein".

Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "alpha-Synuclein" by people in this website by year, and whether "alpha-Synuclein" was a major or minor topic of these publications.

Bar chart showing 42 publications over 18 distinct years, with a maximum of 6 publications in 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2005	1	1	2
2006	3	2	5
2008	3	0	3
2009	0	1	1
2010	0	1	1
2011	1	1	2
2012	0	2	2
2013	1	0	1
2014	0	1	1
2016	1	1	2
2017	1	1	2
2018	6	0	6
2019	1	2	3
2020	2	2	4
2021	0	1	1
2022	1	0	1
2023	2	2	4

Below are the most recent publications written about "alpha-Synuclein" by people in Profiles.

Maurer M, Lazaridis T. Transmembrane ?-Barrel Models of a-Synuclein Oligomers. J Chem Inf Model. 2023 11 27; 63(22):7171-7179.

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Ramirez E, Ganegamage SK, Min S, Patel H, Ogunware A, Plascencia-Villa G, Alnakhala H, Shimanaka K, Tripathi A, Wang KW, Zhu X, Rochet JC, Kuo MH, Counts SE, Perry G, Dettmer U, Lasagna-Reeves CA, Fortin JS. Evaluation of N- and O-Linked Indole Triazines for a Dual Effect on a-Synuclein and Tau Aggregation. ACS Chem Neurosci. 2023 11 01; 14(21):3913-3927.

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Yu M, Ye H, De-Paula RB, Mangleburg CG, Wu T, Lee TV, Li Y, Duong D, Phillips B, Cruchaga C, Allen GI, Seyfried NT, Al-Ramahi I, Botas J, Shulman JM. Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity. PLoS Genet. 2023 05; 19(5):e1010760.

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Dabiri S, Ram?rez Ruiz MI, Jean-Louis G, Ntekim OE, Obisesan TO, Campbell AL, Mwendwa DT. The Mediating Role of Inflammation in the Relationship Between a-Synuclein and Cognitive Functioning. J Gerontol A Biol Sci Med Sci. 2023 02 24; 78(2):206-212.

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Henr?quez G, M?ndez L, Casta?eda E, Wagler A, Jeon S, Narayan M. Preclinical Model to Evaluate Outcomes of Amyloid Cross-Toxicity in the Rodent Brain. ACS Chem Neurosci. 2022 10 19; 13(20):2962-2973.

View in: PubMed
Petyuk VA, Yu L, Olson HM, Yu F, Clair G, Qian WJ, Shulman JM, Bennett DA. Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss. J Proteome Res. 2021 05 07; 20(5):2266-2282.

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Nyarko-Danquah I, Pajarillo E, Digman A, Soliman KFA, Aschner M, Lee E. Manganese Accumulation in the Brain via Various Transporters and Its Neurotoxicity Mechanisms. Molecules. 2020 Dec 12; 25(24).

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Henr?quez G, Gomez A, Guerrero E, Narayan M. Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies. ACS Chem Neurosci. 2020 10 07; 11(19):2915-2934.

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Takaichi Y, Chambers JK, Inoue H, Ano Y, Takashima A, Nakayama H, Uchida K. Phosphorylation and oligomerization of a-synuclein associated with GSK-3? activation in the rTg4510 mouse model of tauopathy. Acta Neuropathol Commun. 2020 06 19; 8(1):86.

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Chen Y, Sam R, Sharma P, Chen L, Do J, Sidransky E. Glucocerebrosidase as a therapeutic target for Parkinson's disease. Expert Opin Ther Targets. 2020 04; 24(4):287-294.

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