Metabolic Detoxication, Phase II
"Metabolic Detoxication, Phase II" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The conjugation of exogenous substances with various hydrophilic substituents to form water soluble products that are excretable in URINE. Phase II modifications include GLUTATHIONE conjugation; ACYLATION; and AMINATION. Phase II enzymes include GLUTATHIONE TRANSFERASE and GLUCURONOSYLTRANSFERASE. In a sense these reactions detoxify phase I reaction products.
| Descriptor ID |
D050217
|
| MeSH Number(s) |
G03.171.450.750 G03.787.225.450.750 G07.690.725.225.450.750
|
| Concept/Terms |
Metabolic Detoxication, Phase II- Metabolic Detoxication, Phase II
- Metabolic Detoxication, Conjugative
- Conjugative Metabolic Detoxication
- Conjugative Metabolic Detoxications
- Detoxication, Conjugative Metabolic
- Detoxications, Conjugative Metabolic
- Metabolic Detoxications, Conjugative
- Phase II Detoxification
- Detoxification, Phase II
- Detoxifications, Phase II
- Phase II Detoxifications
- Metabolic Detoxification, Phase II
|
Below are MeSH descriptors whose meaning is more general than "Metabolic Detoxication, Phase II".
Below are MeSH descriptors whose meaning is more specific than "Metabolic Detoxication, Phase II".
This graph shows the total number of publications written about "Metabolic Detoxication, Phase II" by people in this website by year, and whether "Metabolic Detoxication, Phase II" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "Metabolic Detoxication, Phase II" by people in Profiles.
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Panee J, Stoytcheva ZR, Liu W, Berry MJ. Selenoprotein H is a redox-sensing high mobility group family DNA-binding protein that up-regulates genes involved in glutathione synthesis and phase II detoxification. J Biol Chem. 2007 Aug 17; 282(33):23759-65.
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Dai G, Chou N, He L, Gyamfi MA, Mendy AJ, Slitt AL, Klaassen CD, Wan YJ. Retinoid X receptor alpha Regulates the expression of glutathione s-transferase genes and modulates acetaminophen-glutathione conjugation in mouse liver. Mol Pharmacol. 2005 Dec; 68(6):1590-6.