Proto-Oncogene Proteins c-raf

"Proto-Oncogene Proteins c-raf" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.

Descriptor ID	D019908
MeSH Number(s)	D08.811.913.696.620.682.700.559.842.500 D12.644.360.400.842.500 D12.776.476.400.842.500 D12.776.624.664.700.204.500
Concept/Terms	Proto-Oncogene Proteins c-raf Proto-Oncogene Proteins c-raf Proteins c-raf, Proto-Oncogene Proto Oncogene Proteins c raf c-raf, Proto-Oncogene Proteins Proto-Oncogene Protein c-raf Protein c-raf, Proto-Oncogene Proto Oncogene Protein c raf c-raf, Proto-Oncogene Protein c-raf Kinases Kinases, c-raf c raf Kinases Kinase Raf-1 Kinase Raf 1 Raf-1, Kinase cRaf1 Kinase Kinase, cRaf1 raf-1 Kinase Kinase, raf-1 raf 1 Kinase c-raf Proteins Proteins, c-raf c raf Proteins Kinase p74(raf-1)

Below are MeSH descriptors whose meaning is more general than "Proto-Oncogene Proteins c-raf".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
Phosphotransferases [D08.811.913.696]
Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
Protein Kinases [D08.811.913.696.620.682]
Protein-Serine-Threonine Kinases [D08.811.913.696.620.682.700]
MAP Kinase Kinase Kinases [D08.811.913.696.620.682.700.559]
raf Kinases [D08.811.913.696.620.682.700.559.842]
Proto-Oncogene Proteins c-raf [D08.811.913.696.620.682.700.559.842.500]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Intracellular Signaling Peptides and Proteins [D12.644.360]
MAP Kinase Kinase Kinases [D12.644.360.400]
raf Kinases [D12.644.360.400.842]
Proto-Oncogene Proteins c-raf [D12.644.360.400.842.500]
Proteins [D12.776]
Intracellular Signaling Peptides and Proteins [D12.776.476]
MAP Kinase Kinase Kinases [D12.776.476.400]
raf Kinases [D12.776.476.400.842]
Proto-Oncogene Proteins c-raf [D12.776.476.400.842.500]
Neoplasm Proteins [D12.776.624]
Oncogene Proteins [D12.776.624.664]
Proto-Oncogene Proteins [D12.776.624.664.700]
raf Kinases [D12.776.624.664.700.204]
Proto-Oncogene Proteins c-raf [D12.776.624.664.700.204.500]

Below are MeSH descriptors whose meaning is related to "Proto-Oncogene Proteins c-raf".

Below are MeSH descriptors whose meaning is more specific than "Proto-Oncogene Proteins c-raf".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Proto-Oncogene Proteins c-raf" by people in this website by year, and whether "Proto-Oncogene Proteins c-raf" was a major or minor topic of these publications.

Bar chart showing 10 publications over 7 distinct years, with a maximum of 2 publications in 1995 and 2002 and 2005

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1995	0	2	2
1996	0	1	1
1999	1	0	1
2002	1	1	2
2003	1	0	1
2005	0	2	2
2008	0	1	1

Below are the most recent publications written about "Proto-Oncogene Proteins c-raf" by people in Profiles.

Dhandapany PS, Razzaque MA, Muthusami U, Kunnoth S, Edwards JJ, Mulero-Navarro S, Riess I, Pardo S, Sheng J, Rani DS, Rani B, Govindaraj P, Flex E, Yokota T, Furutani M, Nishizawa T, Nakanishi T, Robbins J, Limongelli G, Hajjar RJ, Lebeche D, Bahl A, Khullar M, Rathinavel A, Sadler KC, Tartaglia M, Matsuoka R, Thangaraj K, Gelb BD. RAF1 mutations in childhood-onset dilated cardiomyopathy. Nat Genet. 2014 Jun; 46(6):635-639.

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Shan L, Zhang R, Zhang W, Lee E, Sridhar R, Snyderwine EG, Wang PC. Image-based evaluation of the molecular events underlying HC11 mammary epithelial cell differentiation. Anal Biochem. 2008 Nov 15; 382(2):122-8.

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Stokes AJ, Shimoda LM, Lee JW, Rillero C, Chang YT, Turner H. Fcepsilon RI control of Ras via inositol (1,4,5) trisphosphate 3-kinase and inositol tetrakisphosphate. Cell Signal. 2006 May; 18(5):640-51.

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Tarzami ST, Hsieh SS, Esterman MA, Singh JP. Staurosporine promotes endothelial cell assembly and FAK phosphorylation during in vitro angiogenesis. J Cardiovasc Pharmacol. 2005 Jan; 45(1):22-9.

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Miura S, Tanigawa H, Matsuo Y, Fujino M, Kawamura A, Saku K. Ras/Raf1-dependent signal in sphingosine-1-phosphate-induced tube formation in human coronary artery endothelial cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):924-9.

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Nagy ZS, Wang Y, Erwin-Cohen RA, Aradi J, Monia B, Wang LH, Stepkowski SM, Rui H, Kirken RA. Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways. J Leukoc Biol. 2002 Oct; 72(4):819-28.

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Joseph T, Bryant A, Frankel P, Wooden R, Kerkhoff E, Rapp UR, Foster DA. Phospholipase D overcomes cell cycle arrest induced by high-intensity Raf signaling. Oncogene. 2002 May 16; 21(22):3651-8.

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Subramaniam SV, Pearson LL, Adunyah SE. Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937. Biochem Biophys Res Commun. 1999 May 27; 259(1):172-7.

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Popik W, Pitha PM. Binding of human immunodeficiency virus type 1 to CD4 induces association of Lck and Raf-1 and activates Raf-1 by a Ras-independent pathway. Mol Cell Biol. 1996 Nov; 16(11):6532-41.

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Adunyah SE, Spencer GC, Cooper RS, Rivero JA, Ceesay K. Interleukin-11 induces tyrosine phosphorylation, and c-jun and c-fos mRNA expression in human K562 and U937 cells. Ann N Y Acad Sci. 1995 Sep 07; 766:296-9.

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