Phosphatidylinositol 4,5-Diphosphate
"Phosphatidylinositol 4,5-Diphosphate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
| Descriptor ID |
D019269
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| MeSH Number(s) |
D10.570.755.375.760.400.942.625.900
|
| Concept/Terms |
Phosphatidylinositol 4,5-Diphosphate- Phosphatidylinositol 4,5-Diphosphate
- 4,5-Diphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Diphosphate
- Phosphatidylinositol Phosphate, PtdIns(4,5)P2
- PtIns 4,5-P2
- PtdIns(4,5)P2
- PtdInsP
- PtdInsP2
- Phosphatidylinositol 4,5-Biphosphate
- 4,5-Biphosphate, Phosphatidylinositol
- Phosphatidylinositol 4,5 Biphosphate
- Phosphatidylinositol-4,5-Biphosphate
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Below are MeSH descriptors whose meaning is more general than "Phosphatidylinositol 4,5-Diphosphate".
Below are MeSH descriptors whose meaning is more specific than "Phosphatidylinositol 4,5-Diphosphate".
This graph shows the total number of publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in this website by year, and whether "Phosphatidylinositol 4,5-Diphosphate" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2006 | 2 | 1 | 3 |
| 2022 | 0 | 1 | 1 |
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Below are the most recent publications written about "Phosphatidylinositol 4,5-Diphosphate" by people in Profiles.
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Wei W, Zheng B, Zheng S, Wu D, Chu Y, Zhang S, Wang D, Ma X, Liu X, Yao X, Fu C. The Cdc42 GAP Rga6 promotes monopolar outgrowth of spores. J Cell Biol. 2023 01 02; 222(1).
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Zaika O, Lara LS, Gamper N, Hilgemann DW, Jaffe DB, Shapiro MS. Angiotensin II regulates neuronal excitability via phosphatidylinositol 4,5-bisphosphate-dependent modulation of Kv7 (M-type) K+ channels. J Physiol. 2006 Aug 15; 575(Pt 1):49-67.
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Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, Zhou R, Watson C, Fu C, Hu Q, Lillard JW, Powell M, Chen Y, Forte JG, Yao X. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. Mol Cell Proteomics. 2006 Aug; 5(8):1437-49.
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Bedi D, Clarke KJ, Dennis JC, Zhong Q, Brunson BL, Morrison EE, Judd RL. Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism. Biochem Biophys Res Commun. 2006 Jun 23; 345(1):332-9.
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Chockalingam PS, Gee SH, Jarrett HW. Pleckstrin homology domain 1 of mouse alpha 1-syntrophin binds phosphatidylinositol 4,5-bisphosphate. Biochemistry. 1999 Apr 27; 38(17):5596-602.