CpG Islands

"CpG Islands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.

Descriptor ID	D018899
MeSH Number(s)	G02.111.570.080.380.160 G05.360.080.380.160 G05.360.340.024.159
Concept/Terms	CpG Islands CpG Islands CpG Island Island, CpG Islands, CpG CpG-Rich Islands CpG Rich Islands CpG-Rich Island Island, CpG-Rich Islands, CpG-Rich CpG Clusters CpG Clusters Cluster, CpG Clusters, CpG CpG Cluster

Below are MeSH descriptors whose meaning is more general than "CpG Islands".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
GC Rich Sequence [G02.111.570.080.380]
CpG Islands [G02.111.570.080.380.160]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
GC Rich Sequence [G05.360.080.380]
CpG Islands [G05.360.080.380.160]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
CpG Islands [G05.360.340.024.159]

Below are MeSH descriptors whose meaning is related to "CpG Islands".

Below are MeSH descriptors whose meaning is more specific than "CpG Islands".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CpG Islands" by people in this website by year, and whether "CpG Islands" was a major or minor topic of these publications.

Bar chart showing 81 publications over 25 distinct years, with a maximum of 8 publications in 2007 and 2013

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2002	0	2	2
2003	1	0	1
2004	1	3	4
2005	1	3	4
2007	0	8	8
2008	0	4	4
2009	1	1	2
2010	1	1	2
2011	0	2	2
2012	0	3	3
2013	1	7	8
2014	1	3	4
2015	1	4	5
2016	0	1	1
2017	0	1	1
2018	0	4	4
2019	1	3	4
2020	0	5	5
2021	0	5	5
2022	0	2	2
2023	0	3	3
2024	2	2	4
2025	0	1	1

Below are the most recent publications written about "CpG Islands" by people in Profiles.

Smith AK, Katrinli S, Maihofer AX, Aiello AE, Baker DG, Boks MP, Brick LA, Chen CY, Dalvie S, Fani N, Fortier CB, Gelernter J, Geuze E, Gillespie CF, Hayes JP, Hong S, Kessler RC, King AP, Koen N, Koenen KC, Liberzon I, Linnstaedt SD, McLean SA, Michopoulos V, Milberg WP, Miller MW, Mufford MS, Nugent NR, Orcutt HK, Powers A, Rauch SAM, Ressler KJ, Risbrough VB, Rutten BPF, Smoller JW, Stein DJ, Stein MB, Ursano RJ, Verfaellie MH, Vermetten E, Vinkers CH, Wani AH, WareVinkers EB, Wildman DE, Wolf EJ, Zhao Y, Logue MW, Nievergelt CM, Uddin M, Zannas AS. Cell-type-specific and inflammatory DNA methylation patterns associated with PTSD. Brain Behav Immun. 2025 Aug; 128:540-548.

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Katrinli S, Wani AH, Maihofer AX, Ratanatharathorn A, Daskalakis NP, Montalvo-Ortiz J, N??ez-R?os DL, Zannas AS, Zhao X, Aiello AE, Ashley-Koch AE, Avetyan D, Baker DG, Beckham JC, Boks MP, Brick LA, Bromet E, Champagne FA, Chen CY, Dalvie S, Dennis MF, Fatumo S, Fortier C, Galea S, Garrett ME, Geuze E, Grant G, Hauser MA, Hayes JP, Hemmings SMJ, Huber BR, Jajoo A, Jansen S, Kessler RC, Kimbrel NA, King AP, Kleinman JE, Koen N, Koenen KC, Kuan PF, Liberzon I, Linnstaedt SD, Lori A, Luft BJ, Luykx JJ, Marx CE, McLean SA, Mehta D, Milberg W, Miller MW, Mufford MS, Musanabaganwa C, Mutabaruka J, Mutesa L, Nemeroff CB, Nugent NR, Orcutt HK, Qin XJ, Rauch SAM, Ressler KJ, Risbrough VB, Rutembesa E, Rutten BPF, Seedat S, Stein DJ, Stein MB, Toikumo S, Ursano RJ, Uwineza A, Verfaellie MH, Vermetten E, Vinkers CH, Ware EB, Wildman DE, Wolf EJ, Young RM, Zhao Y, van den Heuvel LL, Uddin M, Nievergelt CM, Smith AK, Logue MW. Epigenome-wide association studies identify novel DNA methylation sites associated with PTSD: a meta-analysis of 23 military and civilian cohorts. Genome Med. 2024 Dec 18; 16(1):147.

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Walayat A, Hosseini M, Nepal C, Li Y, Chen W, Chen Z, Huang X, Shao XM, Zhang L, Wang C, Xiao D. Maternal e-cigarette exposure alters DNA methylome, site-specific CpG and CH methylation, and transcriptomic signatures in the neonatal brain. Sci Rep. 2024 10 16; 14(1):24263.

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Berglund A, Yamoah K, Eschrich SA, Falahat R, Mul? JJ, Kim S, Matta J, Dutil J, Ruiz-Deya G, Ortiz Sanchez C, Wang L, Park H, Banerjee HN, Lotan T, Barry KH, Putney RM, Kim SJ, Gwede C, Kresovich JK, Kim Y, Lin HY, Dhillon J, Chakrabarti R, Park JY. Epigenome-wide association study of prostate cancer in African American men identified differentially methylated genes. Cancer Med. 2024 Aug; 13(16):e70044.

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Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL. Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts. Am J Hum Genet. 2024 03 07; 111(3):456-472.

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Sun Y, Zhu J, Yang Y, Zhang Z, Zhong H, Zeng G, Zhou D, Nowakowski RS, Long J, Wu C, Wu L. Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data. Transl Psychiatry. 2023 12 13; 13(1):387.

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Zheng Y, Lunetta KL, Liu C, Smith AK, Sherva R, Miller MW, Logue MW. A novel principal component based method for identifying differentially methylated regions in Illumina Infinium MethylationEPIC BeadChip data. Epigenetics. 2023 12; 18(1):2207959.

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Creighton CJ, Zhang F, Zhang Y, Castro P, Hu R, Islam M, Ghosh S, Ittmann M, Kwabi-Addo B. Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer. Epigenetics. 2023 12; 18(1):2180585.

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Zheng Y, Lunetta KL, Liu C, Katrinli S, Smith AK, Miller MW, Logue MW. An evaluation of the genome-wide false positive rates of common methods for identifying differentially methylated regions using illumina methylation arrays. Epigenetics. 2022 12; 17(13):2241-2258.

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Gong T, Borgard H, Zhang Z, Chen S, Gao Z, Deng Y. Analysis and Performance Assessment of the Whole Genome Bisulfite Sequencing Data Workflow: Currently Available Tools and a Practical Guide to Advance DNA Methylation Studies. Small Methods. 2022 03; 6(3):e2101251.

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