CpG Islands

"CpG Islands" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.

Descriptor ID	D018899
MeSH Number(s)	G02.111.570.080.380.160 G05.360.080.380.160 G05.360.340.024.159
Concept/Terms	CpG Islands CpG Islands CpG Island Island, CpG Islands, CpG CpG-Rich Islands CpG Rich Islands CpG-Rich Island Island, CpG-Rich Islands, CpG-Rich CpG Clusters CpG Clusters Cluster, CpG Clusters, CpG CpG Cluster

Below are MeSH descriptors whose meaning is more general than "CpG Islands".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
GC Rich Sequence [G02.111.570.080.380]
CpG Islands [G02.111.570.080.380.160]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
GC Rich Sequence [G05.360.080.380]
CpG Islands [G05.360.080.380.160]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
CpG Islands [G05.360.340.024.159]

Below are MeSH descriptors whose meaning is related to "CpG Islands".

Below are MeSH descriptors whose meaning is more specific than "CpG Islands".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "CpG Islands" by people in this website by year, and whether "CpG Islands" was a major or minor topic of these publications.

Bar chart showing 70 publications over 24 distinct years, with a maximum of 8 publications in 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1998	0	1	1
2000	0	1	1
2002	0	3	3
2003	1	0	1
2004	1	3	4
2005	1	2	3
2007	0	8	8
2008	0	3	3
2009	1	1	2
2010	1	2	3
2011	0	2	2
2012	0	2	2
2013	1	6	7
2014	1	3	4
2015	1	4	5
2016	0	1	1
2017	0	1	1
2018	0	4	4
2019	1	3	4
2020	0	4	4
2021	0	4	4
2022	0	1	1
2023	0	1	1
2024	0	1	1

Below are the most recent publications written about "CpG Islands" by people in Profiles.

Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL. Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts. Am J Hum Genet. 2024 03 07; 111(3):456-472.

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Creighton CJ, Zhang F, Zhang Y, Castro P, Hu R, Islam M, Ghosh S, Ittmann M, Kwabi-Addo B. Comparative and integrative analysis of transcriptomic and epigenomic-wide DNA methylation changes in African American prostate cancer. Epigenetics. 2023 12; 18(1):2180585.

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Gong T, Borgard H, Zhang Z, Chen S, Gao Z, Deng Y. Analysis and Performance Assessment of the Whole Genome Bisulfite Sequencing Data Workflow: Currently Available Tools and a Practical Guide to Advance DNA Methylation Studies. Small Methods. 2022 03; 6(3):e2101251.

View in: PubMed
Berglund A, Matta J, Encarnaci?n-Medina J, Ortiz-Sanch?z C, Dutil J, Linares R, Marcial J, Abreu-Takemura C, Moreno N, Putney R, Chakrabarti R, Lin HY, Yamoah K, Osterman CD, Wang L, Dhillon J, Kim Y, Kim SJ, Ruiz-Deya G, Park JY. Dysregulation of DNA Methylation and Epigenetic Clocks in Prostate Cancer among Puerto Rican Men. Biomolecules. 2021 12 21; 12(1).

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Walayat A, Li Y, Zhang Y, Fu Y, Liu B, Shao XM, Zhang L, Xiao D. Fetal e-cigarette exposure programs a neonatal brain hypoxic-ischemic sensitive phenotype via altering DNA methylation patterns and autophagy signaling pathway. Am J Physiol Regul Integr Comp Physiol. 2021 11 01; 321(5):R791-R801.

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Zhu J, Yang Y, Kisiel JB, Mahoney DW, Michaud DS, Guo X, Taylor WR, Shu XO, Shu X, Liu D, Li B, Tao R, Cai Q, Zheng W, Long J, Wu L. Integrating Genome and Methylome Data to Identify Candidate DNA Methylation Biomarkers for Pancreatic Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2021 11; 30(11):2079-2087.

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Ruiz-Deya G, Matta J, Encarnaci?n-Medina J, Ortiz-Sanch?z C, Dutil J, Putney R, Berglund A, Dhillon J, Kim Y, Park JY. Differential DNA Methylation in Prostate Tumors from Puerto Rican Men. Int J Mol Sci. 2021 Jan 13; 22(2).

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Jian J, Zhang P, Li Y, Liu B, Zhang Y, Zhang L, Shao XM, Zhuang J, Xiao D. Reprogramming of miR-181a/DNA methylation patterns contribute to the maternal nicotine exposure-induced fetal programming of cardiac ischemia-sensitive phenotype in postnatal life. Theranostics. 2020; 10(25):11820-11836.

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Jiang Y, Forno E, Han YY, Xu Z, Hu D, Boutaoui N, Eng C, Acosta-P?rez E, Huntsman S, Col?n-Semidey A, Keys KL, Rodr?guez-Santana JR, Alvarez M, Pino-Yanes M, Canino G, Chen W, Burchard EG, Celed?n JC. A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth. Epigenetics. 2021 05; 16(5):577-585.

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Wu L, Yang Y, Guo X, Shu XO, Cai Q, Shu X, Li B, Tao R, Wu C, Nikas JB, Sun Y, Zhu J, Roobol MJ, Giles GG, Brenner H, John EM, Clements J, Grindedal EM, Park JY, Stanford JL, Kote-Jarai Z, Haiman CA, Eeles RA, Zheng W, Long J. An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk. Nat Commun. 2020 08 06; 11(1):3905.

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