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Lang Wu, PhD

TitleDirector, Pacific Center for Genome Research
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii at Manoa
DepartmentCancer Epidemiology
AddressUniversity of Hawaii Cancer Center
701 Ilalo St
Honolulu HI 96813
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    Collapse Research 
    Collapse research activities and funding
    K99CA218892     (WU, LANG)Apr 1, 2018 - Apr 13, 2019
    NIH
    Uncovering roles of polyunsaturated fatty acids in pancreatic cancer etiology
    Role: Principal Investigator
    R00CA218892     (WU, LANG)Apr 1, 2018 - Jul 31, 2022
    NIH
    Uncovering roles of polyunsaturated fatty acids in pancreatic cancer etiology
    Role: Principal Investigator
    R01CA263494     (WU, LANG)Jul 1, 2022 - Jun 30, 2027
    NIH
    Uncovering causal protein markers to improve prostate cancer etiology understanding and risk prediction in Africans and Europeans
    Role: Principal Investigator
    U54HG013243     (WU, LANG)Sep 15, 2023 - May 31, 2028
    NIH
    Pacific Center for Genome Research
    Role: Principal Investigator
    U01CA293883     (WU, LANG)Sep 18, 2024 - Aug 31, 2029
    NIH
    Uncovering Causal Protein Markers to Characterize Pancreatic Cancer Etiology and Improve Risk Prediction
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Feng Z, Nasu M, Devendra G, Abdul-Ghani AA, Chan OTM, Borgia JA, Gao Z, Zhang H, Chen Y, Gong T, Luo G, Yang H, Wu L, Fu Y, Deng Y. Liquid biopsy diagnostics for non-small cell lung cancer via elucidation of tRNA signatures. Commun Med (Lond). 2025 Aug 21; 5(1):364. PMID: 40841456.
      Citations:    
    2. Gao Z, Nasu M, Devendra G, Abdul-Ghani AA, Herrera AJ, Borgia JA, Seder CW, Kuehu DL, Feng Z, Chen Y, Gong T, Zhang Z, Chan O, Yang H, Yu J, Fu Y, Wu L, Deng Y. A robust machine learning model based on ribosomal-subunit-derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large-scale of sequencing data. Clin Transl Med. 2025 Aug; 15(8):e70418. PMID: 40714929.
      Citations: 1     Fields:    Translation:Humans
    3. Liu S, Zhu J, Zhong H, Wu C, Xue H, Darst BF, Guo X, Durda P, Tracy RP, Liu Y, Johnson WC, Taylor KD, Manichaikul AW, Goodarzi MO, Gerszten RE, Clish CB, Chen YI, Highland H, Haiman CA, Gignoux CR, Lange L, Conti DV, Raffield LM, Wilkens L, Marchand LL, North KE, Young KL, Loos RJ, Buyske S, Matise T, Peters U, Kooperberg C, Reiner AP, Yu B, Boerwinkle E, Sun Q, Rooney MR, Echouffo-Tcheugui JB, Daviglus ML, Qi Q, Mancuso N, Li C, Deng Y, Manning A, Meigs JB, Rich SS, Rotter JI, Wu L. Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations. Diabetologia. 2024 Dec; 67(12):2754-2770. PMID: 39349773.
      Citations: 2     Fields:    Translation:Humans
    4. Xia WF, Zheng XL, Liu WY, Huang YT, Wen CJ, Zhou HH, Wu QC, Wu LX. Romidepsin exhibits anti-esophageal squamous cell carcinoma activity through the DDIT4-mTORC1 pathway. Cancer Gene Ther. 2024 May; 31(5):778-789. PMID: 38480975.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Chen Y, Gao Z, Mohd-Ibrahim I, Yang H, Wu L, Fu Y, Deng Y. Pan-cancer analyses of bromodomain containing 9 as a novel therapeutic target reveals its diagnostic, prognostic potential and biological mechanism in human tumours. Clin Transl Med. 2024 02; 14(2):e1543. PMID: 38303608.
      Citations: 8     Fields:    Translation:HumansCells
    6. Liu S, Zhong H, Zhu J, Wu L. Identification of blood metabolites associated with risk of Alzheimer's disease by integrating genomics and metabolomics data. Mol Psychiatry. 2024 Apr; 29(4):1153-1162. PMID: 38216726.
      Citations: 8     Fields:    Translation:Humans
    7. Zhu J, Liu S, Walker KA, Zhong H, Ghoneim DH, Zhang Z, Surendran P, Fahle S, Butterworth A, Alam MA, Deng HW, Wu C, Wu L. Associations between genetically predicted plasma protein levels and Alzheimer's disease risk: a study using genetic prediction models. Alzheimers Res Ther. 2024 01 11; 16(1):8. PMID: 38212844.
      Citations: 8     Fields:    Translation:Humans
    8. Sun Y, Zhu J, Yang Y, Zhang Z, Zhong H, Zeng G, Zhou D, Nowakowski RS, Long J, Wu C, Wu L. Identification of candidate DNA methylation biomarkers related to Alzheimer's disease risk by integrating genome and blood methylome data. Transl Psychiatry. 2023 12 13; 13(1):387. PMID: 38092781.
      Citations: 12     Fields:    Translation:HumansCells
    9. Zhong H, Zhu J, Liu S, Ghoneim DH, Surendran P, Liu T, Fahle S, Butterworth A, Ashad Alam M, Deng HW, Yu H, Wu C, Wu L. Identification of blood protein biomarkers associated with prostate cancer risk using genetic prediction models: analysis of over 140,000 subjects. Hum Mol Genet. 2023 11 03; 32(22):3181-3193. PMID: 37622920.
      Citations: 4     Fields:    Translation:Humans
    10. Zhong H, Liu S, Zhu J, Xu TH, Yu H, Wu L. Elucidating the role of blood metabolites on pancreatic cancer risk using two-sample Mendelian randomization analysis. Int J Cancer. 2024 Mar 01; 154(5):852-862. PMID: 37860916.
      Citations: 13     Fields:    Translation:Humans
    11. Liu S, Zhong H, Zhu J, Wu Y, Deng Y, Wu L. Regulome-wide association study identifies genetically driven accessible regions associated with pancreatic cancer risk. Int J Cancer. 2024 Feb 15; 154(4):670-678. PMID: 37850323.
      Citations: 2     Fields:    Translation:HumansCells
    12. Fu Y, Wu K, Wang Z, Yang H, Chen Y, Wu L, Yanagihara R, Hedges JR, Wang H, Deng Y. Effectiveness of various COVID-19 vaccine regimens among 10.4 million patients from the National COVID Cohort Collaborative during Pre-Delta to Omicron periods - United States, 11 December 2020 to 30 June 2022. Vaccine. 2023 10 06; 41(42):6339-6349. PMID: 37741761.
      Citations: 1     Fields:    Translation:HumansCells
    13. Sun Y, Bae YE, Zhu J, Zhang Z, Zhong H, Yu J, Wu C, Wu L. A splicing transcriptome-wide association study identifies novel altered splicing for Alzheimer's disease susceptibility. Neurobiol Dis. 2023 08; 184:106209. PMID: 37354922.
      Citations: 8     Fields:    Translation:HumansCells
    14. Zhong H, Liu S, Zhu J, Wu L. Associations between genetically predicted levels of blood metabolites and pancreatic cancer risk. Int J Cancer. 2023 07 01; 153(1):103-110. PMID: 36757187.
      Citations: 22     Fields:    Translation:Humans
    15. Shao YY, Zhang TL, Wu LX, Zou HC, Li S, Huang J, Zhou HH. Correction: Shao et al. AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells. Int. J. Mol. Sci. 2017, 18, 350. Int J Mol Sci. 2021 Nov 24; 22(23). PMID: 34884979.
      Citations:    Fields:    
    16. Zhu J, Yang Y, Kisiel JB, Mahoney DW, Michaud DS, Guo X, Taylor WR, Shu XO, Shu X, Liu D, Li B, Tao R, Cai Q, Zheng W, Long J, Wu L. Integrating Genome and Methylome Data to Identify Candidate DNA Methylation Biomarkers for Pancreatic Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2021 11; 30(11):2079-2087. PMID: 34497089.
      Citations: 12     Fields:    Translation:HumansCells
    17. Sun Y, Zhu J, Zhou D, Canchi S, Wu C, Cox NJ, Rissman RA, Gamazon ER, Wu L. A transcriptome-wide association study of Alzheimer's disease using prediction models of relevant tissues identifies novel candidate susceptibility genes. Genome Med. 2021 09 01; 13(1):141. PMID: 34470669.
      Citations: 31     Fields:    Translation:HumansCells
    18. Wu L, Zhu J, Liu D, Sun Y, Wu C. An integrative multiomics analysis identifies putative causal genes for COVID-19 severity. Genet Med. 2021 11; 23(11):2076-2086. PMID: 34183789.
      Citations: 17     Fields:    Translation:HumansCells
    19. Zhu J, O'Mara TA, Liu D, Setiawan VW, Glubb D, Spurdle AB, Fasching PA, Lambrechts D, Buchanan D, Kho PF, Cook LS, Friedenreich C, Lacey JV, Chen C, Wentzensen N, De Vivo I, Sun Y, Long J, Du M, Shu XO, Zheng W, Wu L, Yu H. Associations between Genetically Predicted Circulating Protein Concentrations and Endometrial Cancer Risk. Cancers (Basel). 2021 Apr 26; 13(9). PMID: 33925895.
      Citations:    
    20. Zhu J, Wu C, Wu L. Associations Between Genetically Predicted Protein Levels and COVID-19 Severity. J Infect Dis. 2021 01 04; 223(1):19-22. PMID: 33083826.
      Citations: 12     Fields:    Translation:Humans
    21. Ma Y, Zhu DS, Chen RB, Shi NN, Liu SH, Fan YP, Wu GH, Yang PY, Bai JF, Chen H, Chen LY, Feng Q, Guo TM, Hou Y, Hu GF, Hu XM, Hu YH, Huang J, Huang QH, Huang SZ, Ji L, Jin HH, Lei X, Li CY, Li MQ, Li QT, Li XY, Liu H, Liu JP, Liu Z, Ma YT, Mao Y, Mo LF, Na H, Wang JW, Song FL, Sun S, Wang DT, Wang MX, Wang XY, Wang YZ, Wang YD, Wu W, Wu LP, Xiao YH, Xie HJ, Xu HM, Xu SF, Xue RX, Yang C, Yang KJ, Yuan SL, Zhang GQ, Zhang JB, Zhang LS, Zhao SS, Zhao WY, Zheng K, Zhou YC, Zhu JT, Zhu TQ, Zhang HM, Wang YP, Wang YY. Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China. Biomed Environ Sci. 2020 Dec 20; 33(12):893-905. PMID: 33472729.
      Citations: 15     Fields:    Translation:Humans
    22. Ghoneim DH, Zhu J, Zheng W, Long J, Murff HJ, Ye F, Setiawan VW, Wilkens LR, Khankari NK, Haycock P, Antwi SO, Yang Y, Arslan AA, Beane Freeman LE, Bracci PM, Canzian F, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Le Marchand L, Neale RE, Scelo G, Visvanathan K, White E, Albanes D, Amiano P, Andreotti G, Babic A, Bamlet WR, Berndt SI, Brais LK, Brennan P, Bueno-de-Mesquita B, Buring JE, Campbell PT, Rabe KG, Chanock SJ, Duggal P, Fuchs CS, Gaziano JM, Goggins MG, Hackert T, Hassan MM, Helzlsouer KJ, Holly EA, Hoover RN, Katske V, Kurtz RC, Lee IM, Malats N, Milne RL, Murphy N, Oberg AL, Porta M, Rothman N, Sesso HD, Silverman DT, Thompson IM, Wactawski-Wende J, Wang X, Wentzensen N, Yu H, Zeleniuch-Jacquotte A, Yu K, Wolpin BM, Jacobs EJ, Duell EJ, Risch HA, Petersen GM, Amundadottir LT, Kraft P, Klein AP, Stolzenberg-Solomon RZ, Shu XO, Wu L. Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2020 12; 29(12):2735-2739. PMID: 32967863.
      Citations: 9     Fields:    Translation:Humans
    23. Liu D, Zhou D, Sun Y, Zhu J, Ghoneim D, Wu C, Yao Q, Gamazon ER, Cox NJ, Wu L. A Transcriptome-Wide Association Study Identifies Candidate Susceptibility Genes for Pancreatic Cancer Risk. Cancer Res. 2020 10 15; 80(20):4346-4354. PMID: 32907841.
      Citations: 23     Fields:    Translation:Humans
    24. Wu L, Yang Y, Guo X, Shu XO, Cai Q, Shu X, Li B, Tao R, Wu C, Nikas JB, Sun Y, Zhu J, Roobol MJ, Giles GG, Brenner H, John EM, Clements J, Grindedal EM, Park JY, Stanford JL, Kote-Jarai Z, Haiman CA, Eeles RA, Zheng W, Long J. An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk. Nat Commun. 2020 08 06; 11(1):3905. PMID: 32764609.
      Citations: 28     Fields:    Translation:HumansCells
    25. Zhu J, Shu X, Guo X, Liu D, Bao J, Milne RL, Giles GG, Wu C, Du M, White E, Risch HA, Malats N, Duell EJ, Goodman PJ, Li D, Bracci P, Katzke V, Neale RE, Gallinger S, Van Den Eeden SK, Arslan AA, Canzian F, Kooperberg C, Beane Freeman LE, Scelo G, Visvanathan K, Haiman CA, Le Marchand L, Yu H, Petersen GM, Stolzenberg-Solomon R, Klein AP, Cai Q, Long J, Shu XO, Zheng W, Wu L. Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1501-1508. PMID: 32439797.
      Citations: 20     Fields:    Translation:Humans
    26. Wu L, Shu X, Bao J, Guo X, Kote-Jarai Z, Haiman CA, Eeles RA, Zheng W. Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk. Cancer Res. 2019 09 15; 79(18):4592-4598. PMID: 31337649.
      Citations: 19     Fields:    Translation:Humans
    27. Zou H, Wu LX, Yang Y, Li S, Mei Y, Liu YB, Zhang L, Cheng Y, Zhou HH. lncRNAs PVT1 and HAR1A are prognosis biomarkers and indicate therapy outcome for diffuse glioma patients. Oncotarget. 2017 Oct 03; 8(45):78767-78780. PMID: 29108264.
      Citations: 39     Fields:    
    28. Wu LX, Zhao HB, Wen CJ, Li Y, Shao YY, Yang Z, Zhou HH. Combined Influence of Genetic Polymorphism and DNA Methylation on ABCB1 Expression and Function in Healthy Chinese Males. Eur J Drug Metab Pharmacokinet. 2017 Aug; 42(4):627-634. PMID: 27683186.
      Citations: 4     Fields:    Translation:HumansCells
    29. Shao YY, Zhang TL, Wu LX, Zou HC, Li S, Huang J, Zhou HH. AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells. Int J Mol Sci. 2017 Feb 10; 18(2). PMID: 28208619.
      Citations: 17     Fields:    Translation:HumansCells
    30. Wu LX, Wen CJ, Li Y, Zhang X, Shao YY, Yang Z, Zhou HH. Interindividual epigenetic variation in ABCB1 promoter and its relationship with ABCB1 expression and function in healthy Chinese subjects. Br J Clin Pharmacol. 2015 Nov; 80(5):1109-21. PMID: 25940551.
      Citations: 6     Fields:    Translation:HumansCellsCTClinical Trials
    31. Qin CZ, Zhang X, Wu LX, Wen CJ, Hu L, Lv QL, Shen DY, Zhou HH. Advances in molecular signaling mechanisms of ?-phenethyl isothiocyanate antitumor effects. J Agric Food Chem. 2015 Apr 08; 63(13):3311-22. PMID: 25798652.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    32. Qu Q, Qu J, Zhan M, Wu LX, Zhang YW, Lou XY, Fu LJ, Zhou HH. Different involvement of promoter methylation in the expression of organic cation/carnitine transporter 2 (OCTN2) in cancer cell lines. PLoS One. 2013; 8(10):e76474. PMID: 24146874.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
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