Germinal Center

"Germinal Center" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The activated center of a lymphoid follicle in secondary lymphoid tissue where B-LYMPHOCYTES are stimulated by antigens and helper T cells (T-LYMPHOCYTES, HELPER-INDUCER) are stimulated to generate memory cells.

Descriptor ID	D018858
MeSH Number(s)	A10.549.400.500 A15.382.520.604.412.500
Concept/Terms	Germinal Center Germinal Center Center, Germinal Centers, Germinal Germinal Centers

Below are MeSH descriptors whose meaning is more general than "Germinal Center".

Anatomy [A]
Tissues [A10]
Lymphoid Tissue [A10.549]
Lymph Nodes [A10.549.400]
Germinal Center [A10.549.400.500]
Hemic and Immune Systems [A15]
Immune System [A15.382]
Lymphatic System [A15.382.520]
Lymphoid Tissue [A15.382.520.604]
Lymph Nodes [A15.382.520.604.412]
Germinal Center [A15.382.520.604.412.500]

Below are MeSH descriptors whose meaning is related to "Germinal Center".

Below are MeSH descriptors whose meaning is more specific than "Germinal Center".

Germinal Center
Dendritic Cells, Follicular

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Germinal Center" by people in this website by year, and whether "Germinal Center" was a major or minor topic of these publications.

Bar chart showing 11 publications over 7 distinct years, with a maximum of 3 publications in 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2005	0	1	1
2010	1	0	1
2012	0	1	1
2015	1	1	2
2018	1	1	2
2019	1	0	1
2021	3	0	3

Below are the most recent publications written about "Germinal Center" by people in Profiles.

Ollerton MT, Folkvord JM, Bush V, Parry DA, Meditz AL, McCarter MD, Yost F, Shikuma CM, Connick E. Lymphoid B cells upregulate HIV-1 ex vivo and are linked to its expression in vivo. PLoS Pathog. 2025 Dec; 21(12):e1013661.

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King HW, Wells KL, Shipony Z, Kathiria AS, Wagar LE, Lareau C, Orban N, Capasso R, Davis MM, Steinmetz LM, James LK, Greenleaf WJ. Integrated single-cell transcriptomics and epigenomics reveals strong germinal center-associated etiology of autoimmune risk loci. Sci Immunol. 2021 Oct 15; 6(64):eabh3768.

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Wishnie AJ, Chwat-Edelstein T, Attaway M, Vuong BQ. BCR Affinity Influences T-B Interactions and B Cell Development in Secondary Lymphoid Organs. Front Immunol. 2021; 12:703918.

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Sible E, Zheng S, Choi JE, Vuong BQ. Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches. J Vis Exp. 2021 04 20; (170).

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Nicolas L, Cols M, Smolkin R, Fernandez KC, Yewdell WT, Yen WF, Zha S, Vuong BQ, Chaudhuri J. Cutting Edge: ATM Influences Germinal Center Integrity. J Immunol. 2019 06 01; 202(11):3137-3142.

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Sullivan KE. Neutropenia as a sign of immunodeficiency. J Allergy Clin Immunol. 2019 01; 143(1):96-100.

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Romberg N, Le Coz C, Glauzy S, Schickel JN, Trofa M, Nolan BE, Paessler M, Xu ML, Lambert MP, Lakhani SA, Khokha MK, Jyonouchi S, Heimall J, Takach P, Maglione PJ, Catanzaro J, Hsu FI, Sullivan KE, Cunningham-Rundles C, Meffre E. Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses. J Allergy Clin Immunol. 2019 01; 143(1):258-265.

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Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM. Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol. 2016 Jan 01; 196(1):144-55.

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Dominguez PM, Teater M, Chambwe N, Kormaksson M, Redmond D, Ishii J, Vuong B, Chaudhuri J, Melnick A, Vasanthakumar A, Godley LA, Papavasiliou FN, Elemento O, Shaknovich R. DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID. Cell Rep. 2015 Sep 29; 12(12):2086-98.

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Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012 Jul 06; 150(1):194-206.

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