Gene Rearrangement, B-Lymphocyte, Heavy Chain
"Gene Rearrangement, B-Lymphocyte, Heavy Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.
Descriptor ID |
D015326
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MeSH Number(s) |
G05.344.401.501 G12.500.274.501
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Concept/Terms |
Gene Rearrangement, B-Lymphocyte, Heavy Chain- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- B-Cell Heavy Chain Gene Rearrangement
- B-Lymphocyte Heavy Chain Gene Rearrangement
- B Cell Heavy Chain Gene Rearrangement
- B Lymphocyte Heavy Chain Gene Rearrangement
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Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte, Heavy Chain".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte, Heavy Chain".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte, Heavy Chain" by people in this website by year, and whether "Gene Rearrangement, B-Lymphocyte, Heavy Chain" was a major or minor topic of these publications.
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Year | Major Topic | Minor Topic | Total |
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1995 | 1 | 0 | 1 |
1997 | 1 | 1 | 2 |
1998 | 1 | 1 | 2 |
2004 | 1 | 0 | 1 |
2007 | 1 | 0 | 1 |
2008 | 0 | 1 | 1 |
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Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte, Heavy Chain" by people in Profiles.
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Li F, Eckhardt LA. A role for the IgH intronic enhancer E mu in enforcing allelic exclusion. J Exp Med. 2009 Jan 16; 206(1):153-67.
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Zhang B, Alaie-Petrillo A, Kon M, Li F, Eckhardt LA. Transcription of a productively rearranged Ig VDJC alpha does not require the presence of HS4 in the IgH 3' regulatory region. J Immunol. 2007 May 15; 178(10):6297-306.
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Shiramizu B, Perkins SL, Bergeron S, Lones M, Kelly K, Weiner M, Cairo MS. Assessing immunoglobulin heavy chain rearrangements in pediatric CD20-positive and CD20-negative classic Hodgkin's disease. Clin Lymphoma. 2004 Dec; 5(3):184-9.
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Raaphorst FM, Gokmen E, Teale JM. Analysis of clonal diversity in mouse immunoglobulin heavy chain genes selected for size of the antigen combining site. Immunol Invest. 1998 Dec; 27(6):355-65.
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Gokmen E, Raaphorst FM, Boldt DH, Teale JM. Ig heavy chain third complementarity determining regions (H CDR3s) after stem cell transplantation do not resemble the developing human fetal H CDR3s in size distribution and Ig gene utilization. Blood. 1998 Oct 15; 92(8):2802-14.
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Pan PY, Lieber MR, Teale JM. The role of recombination signal sequences in the preferential joining by deletion in DH-JH recombination and in the ordered rearrangement of the IgH locus. Int Immunol. 1997 Apr; 9(4):515-22.
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Birshtein BK, Chen C, Saleque S, Michaelson JS, Singh M, Little RD. Murine and human 3'IgH regulatory sequences. Curr Top Microbiol Immunol. 1997; 224:73-80.
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Kaplan LD, Shiramizu B, Herndier B, Hahn J, Meeker TC, Ng V, Volberding PA, McGrath MS. Influence of molecular characteristics on clinical outcome in human immunodeficiency virus-associated non-Hodgkin's lymphoma: identification of a subgroup with favorable clinical outcome. Blood. 1995 Apr 01; 85(7):1727-35.
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Turaga PS, Berton MT, Teale JM. Frequency of B cells expressing germ-line gamma 1 transcripts upon IL-4 induction. J Immunol. 1993 Aug 01; 151(3):1383-90.
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Jeong HD, Teale JM. Contribution of the CD5+ B cell to D-proximal VH family expression early in ontogeny. J Immunol. 1990 Oct 15; 145(8):2725-9.