Th1 Cells

"Th1 Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A subset of helper-inducer T-lymphocytes which synthesize and secrete INTERLEUKIN-2; INTERFERON-GAMMA; and INTERLEUKIN-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.

Descriptor ID	D018417
MeSH Number(s)	A11.118.637.555.567.550.500.400.900 A11.118.637.555.567.569.200.400.900 A11.118.637.555.567.569.500.400.900 A15.145.229.637.555.567.550.500.400.500 A15.145.229.637.555.567.569.200.400.500 A15.145.229.637.555.567.569.500.400.500 A15.382.490.555.567.550.500.400.900 A15.382.490.555.567.569.200.400.900 A15.382.490.555.567.569.500.400.900
Concept/Terms	Th1 Cells Th1 Cells Cell, Th1 Cells, Th1 Th1 Cell TH-1 Cells Cell, TH-1 Cells, TH-1 TH 1 Cells TH-1 Cell T Helper 1 Cells Type 1 Helper T Cells

Below are MeSH descriptors whose meaning is more general than "Th1 Cells".

Anatomy [A]
Cells [A11]
Blood Cells [A11.118]
Leukocytes [A11.118.637]
Leukocytes, Mononuclear [A11.118.637.555]
Lymphocytes [A11.118.637.555.567]
Lymphocyte Subsets [A11.118.637.555.567.550]
T-Lymphocyte Subsets [A11.118.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.550.500.400]
Th1 Cells [A11.118.637.555.567.550.500.400.900]
T-Lymphocytes [A11.118.637.555.567.569]
CD4-Positive T-Lymphocytes [A11.118.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.200.400]
Th1 Cells [A11.118.637.555.567.569.200.400.900]
T-Lymphocyte Subsets [A11.118.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A11.118.637.555.567.569.500.400]
Th1 Cells [A11.118.637.555.567.569.500.400.900]
Hemic and Immune Systems [A15]
Blood [A15.145]
Blood Cells [A15.145.229]
Leukocytes [A15.145.229.637]
Leukocytes, Mononuclear [A15.145.229.637.555]
Lymphocytes [A15.145.229.637.555.567]
Lymphocyte Subsets [A15.145.229.637.555.567.550]
T-Lymphocyte Subsets [A15.145.229.637.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.550.500.400]
Th1 Cells [A15.145.229.637.555.567.550.500.400.500]
T-Lymphocytes [A15.145.229.637.555.567.569]
CD4-Positive T-Lymphocytes [A15.145.229.637.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.200.400]
Th1 Cells [A15.145.229.637.555.567.569.200.400.500]
T-Lymphocyte Subsets [A15.145.229.637.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.145.229.637.555.567.569.500.400]
Th1 Cells [A15.145.229.637.555.567.569.500.400.500]
Immune System [A15.382]
Leukocytes [A15.382.490]
Leukocytes, Mononuclear [A15.382.490.555]
Lymphocytes [A15.382.490.555.567]
Lymphocyte Subsets [A15.382.490.555.567.550]
T-Lymphocyte Subsets [A15.382.490.555.567.550.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.550.500.400]
Th1 Cells [A15.382.490.555.567.550.500.400.900]
T-Lymphocytes [A15.382.490.555.567.569]
CD4-Positive T-Lymphocytes [A15.382.490.555.567.569.200]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.200.400]
Th1 Cells [A15.382.490.555.567.569.200.400.900]
T-Lymphocyte Subsets [A15.382.490.555.567.569.500]
T-Lymphocytes, Helper-Inducer [A15.382.490.555.567.569.500.400]
Th1 Cells [A15.382.490.555.567.569.500.400.900]

Below are MeSH descriptors whose meaning is related to "Th1 Cells".

Below are MeSH descriptors whose meaning is more specific than "Th1 Cells".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Th1 Cells" by people in this website by year, and whether "Th1 Cells" was a major or minor topic of these publications.

Bar chart showing 71 publications over 24 distinct years, with a maximum of 6 publications in 1999 and 2006

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1996	1	1	2
1997	0	1	1
1998	2	0	2
1999	1	5	6
2000	0	5	5
2001	2	3	5
2002	1	4	5
2003	3	2	5
2004	2	1	3
2005	1	0	1
2006	0	6	6
2007	2	3	5
2008	0	3	3
2009	1	1	2
2010	3	1	4
2011	2	2	4
2012	0	2	2
2013	0	1	1
2014	1	2	3
2015	0	1	1
2018	0	1	1
2019	0	2	2
2021	1	0	1
2024	0	1	1

Below are the most recent publications written about "Th1 Cells" by people in Profiles.

Mori LP, Corley MJ, McAuley AT, Pang A, Venables T, Ndhlovu LC, Pipkin ME, Valente ST. Transcriptional and methylation outcomes of didehydro-cortistatin A use in HIV-1-infected CD4+ T cells. Life Sci Alliance. 2024 Oct; 7(10).

View in: PubMed
Chauss D, Freiwald T, McGregor R, Yan B, Wang L, Nova-Lamperti E, Kumar D, Zhang Z, Teague H, West EE, Vannella KM, Ramos-Benitez MJ, Bibby J, Kelly A, Malik A, Freeman AF, Schwartz DM, Portilla D, Chertow DS, John S, Lavender P, Kemper C, Lombardi G, Mehta NN, Cooper N, Lionakis MS, Laurence A, Kazemian M, Afzali B. Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells. Nat Immunol. 2022 01; 23(1):62-74.

View in: PubMed
Pais R, Omosun Y, Igietseme JU, Fujihashi K, Eko FO. Route of Vaccine Administration Influences the Impact of Fms-Like Tyrosine Kinase 3 Ligand (Flt3L) on Chlamydial-Specific Protective Immune Responses. Front Immunol. 2019; 10:1577.

View in: PubMed
Lin H, He C, Koprivsek JJ, Chen J, Zhou Z, Arulanandam B, Xu Z, Tang L, Zhong G. Antigen-Specific CD4+ T Cell-Derived Gamma Interferon Is Both Necessary and Sufficient for Clearing Chlamydia from the Small Intestine but Not the Large Intestine. Infect Immun. 2019 06; 87(6).

View in: PubMed
Hung CY, Zhang H, Castro-Lopez N, Ostroff GR, Khoshlenar P, Abraham A, Cole GT, Negron A, Forsthuber T, Peng T, Galgiani JN, Ampel NM, Yu JJ. Glucan-Chitin Particles Enhance Th17 Response and Improve Protective Efficacy of a Multivalent Antigen (rCpa1) against Pulmonary Coccidioides posadasii Infection. Infect Immun. 2018 11; 86(11).

View in: PubMed
Sebastian M, Lopez-Ocasio M, Metidji A, Rieder SA, Shevach EM, Thornton AM. Helios Controls a Limited Subset of Regulatory T Cell Functions. J Immunol. 2016 Jan 01; 196(1):144-55.

View in: PubMed
Walpita P, Johns LM, Tandon R, Moore ML. Mammalian Cell-Derived Respiratory Syncytial Virus-Like Particles Protect the Lower as well as the Upper Respiratory Tract. PLoS One. 2015; 10(7):e0130755.

View in: PubMed
Eko FO, Mania-Pramanik J, Pais R, Pan Q, Okenu DM, Johnson A, Ibegbu C, He C, He Q, Russell R, Black CM, Igietseme JU. Vibrio cholerae ghosts (VCG) exert immunomodulatory effect on dendritic cells for enhanced antigen presentation and induction of protective immunity. BMC Immunol. 2014 Dec 31; 15:584.

View in: PubMed
Raphael I, Nalawade S, Eagar TN, Forsthuber TG. T cell subsets and their signature cytokines in autoimmune and inflammatory diseases. Cytokine. 2015 Jul; 74(1):5-17.

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Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormley FL. STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice. J Immunol. 2014 Oct 15; 193(8):4060-71.

View in: PubMed

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