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Floyd L. Wormley Jr.

TitleAssociate Dean for Research - COS
Faculty RankAssociate Professor
InstitutionUniversity of Texas at San Antonio
DepartmentBiology/STCEID
AddressOne UTSA Circle
Department of Biology
M.B.T. 1.242
San Antonio TX 78249
Phone(210) 458-7020
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    Dr. Wormley received his B.S. degree in Cellular and Molecular Biology from Tulane University in New Orleans, LA and his M.S. and Ph.D. degrees from Louisiana State University Health Science Center also in New Orleans, LA. He then conducted his post-doctoral studies in Infectious Diseases at Duke University Medical Center in Durham, NC prior to joining the faculty in the Department of Biology at The University of Texas at San Antonio (UTSA) in 2005. Dr. Wormley’s research laboratory utilizes the human fungal pathogen Cryptococcus neoformans as a model organism to study host-fungal interactions for the purpose of developing novel immune therapies and/or vaccines to treat and/or prevent invasive fungal infections. C. neoformans infections are a significant cause of morbidity and mortality among AIDS patients. In sub-Saharan Africa, deaths due to cryptococcal meningitis (530,000) appear to be more frequent than tuberculosis (350,000). Dr. Wormley’s research is supported by two grants from the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) and he is co-investigator on a training grant funded by the Department of Defense. He currently is a standing member of the AIDS-Associated Opportunistic Infections and Cancer (AOIC) NIH study section, a member of the Committee on Microbiological Issues Impacting Minorities for the American Society for Microbiology (ASM), Associate Director of the South Texas Center for Emerging Infectious Diseases, and Associate Dean for Research in the College of Sciences at UTSA.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhai B, Wozniak KL, Masso-Silva J, Upadhyay S, Hole C, Rivera A, Wormley FL, Lin X. Development of protective inflammation and cell-mediated immunity against Cryptococcus neoformans after exposure to hyphal mutants. mBio. 2015 Oct 06; 6(5):e01433-15. PMID: 26443458.
      Citations: 40     Fields:    Translation:Animals
    2. Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Mueller M, Wormley FL. STAT1 signaling within macrophages is required for antifungal activity against Cryptococcus neoformans. Infect Immun. 2015 Dec; 83(12):4513-27. PMID: 26351277.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    3. Leopold Wager CM, Wormley FL. Is Development of a Vaccine against Cryptococcus neoformans Feasible? PLoS Pathog. 2015 Jun; 11(6):e1004843. PMID: 26087178.
      Citations: 13     Fields:    Translation:HumansAnimals
    4. Eastman AJ, He X, Qiu Y, Davis MJ, Vedula P, Lyons DM, Park YD, Hardison SE, Malachowski AN, Osterholzer JJ, Wormley FL, Williamson PR, Olszewski MA. Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization. J Immunol. 2015 Jun 15; 194(12):5999-6010. PMID: 25972480.
      Citations: 27     Fields:    Translation:AnimalsCells
    5. Wozniak KL, Olszewski MA, Wormley FL. Molecules at the interface of Cryptococcus and the host that determine disease susceptibility. Fungal Genet Biol. 2015 May; 78:87-92. PMID: 25445308.
      Citations: 11     Fields:    Translation:Animals
    6. Rane HS, Hardison S, Botelho C, Bernardo SM, Wormley F, Lee SA. Candida albicans VPS4 contributes differentially to epithelial and mucosal pathogenesis. Virulence. 2014; 5(8):810-8. PMID: 25483774.
      Citations: 7     Fields:    Translation:AnimalsCells
    7. Leopold Wager CM, Hole CR, Wozniak KL, Olszewski MA, Wormley FL. STAT1 signaling is essential for protection against Cryptococcus neoformans infection in mice. J Immunol. 2014 Oct 15; 193(8):4060-71. PMID: 25200956.
      Citations: 53     Fields:    Translation:AnimalsCells
    8. Chaturvedi AK, Hameed RS, Wozniak KL, Hole CR, Leopold Wager CM, Weintraub ST, Lopez-Ribot JL, Wormley FL. Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice. PLoS One. 2014; 9(8):e104316. PMID: 25119981.
      Citations: 24     Fields:    Translation:Animals
    9. Feretzaki M, Hardison SE, Wormley FL, Heitman J. Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. PLoS One. 2014; 9(8):e104432. PMID: 25093333.
      Citations: 11     Fields:    Translation:AnimalsCells
    10. Leopold Wager CM, Wormley FL. Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections. Mucosal Immunol. 2014 Sep; 7(5):1023-35. PMID: 25073676.
      Citations: 90     Fields:    Translation:Humans
    11. Wozniak KL, Hole CR, Yano J, Fidel PL, Wormley FL. Characterization of IL-22 and antimicrobial peptide production in mice protected against pulmonary Cryptococcus neoformans infection. Microbiology (Reading). 2014 Jul; 160(Pt 7):1440-1452. PMID: 24760968.
      Citations: 18     Fields:    Translation:HumansAnimals
    12. Chaturvedi AK, Weintraub ST, Lopez-Ribot JL, Wormley FL. Identification and characterization of Cryptococcus neoformans protein fractions that induce protective immune responses. Proteomics. 2013 Dec; 13(23-24):3429-41. PMID: 24170628.
      Citations: 22     Fields:    Translation:AnimalsCellsPHPublic Health
    13. Chaturvedi AK, Wormley FL. Cryptococcus antigens and immune responses: implications for a vaccine. Expert Rev Vaccines. 2013 Nov; 12(11):1261-72. PMID: 24156284.
      Citations: 13     Fields:    Translation:HumansAnimals
    14. Wozniak KL, Kolls JK, Wormley FL. Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by ?d T cells. BMC Immunol. 2012 Dec 07; 13:65. PMID: 23216912.
      Citations: 51     Fields:    Translation:AnimalsCells
    15. Hole CR, Bui H, Wormley FL, Wozniak KL. Mechanisms of dendritic cell lysosomal killing of Cryptococcus. Sci Rep. 2012; 2:739. PMID: 23074646.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    16. Yano J, Kolls JK, Happel KI, Wormley F, Wozniak KL, Fidel PL. The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway. PLoS One. 2012; 7(9):e46311. PMID: 23050010.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    17. Hardison SE, Herrera G, Young ML, Hole CR, Wozniak KL, Wormley FL. Protective immunity against pulmonary cryptococcosis is associated with STAT1-mediated classical macrophage activation. J Immunol. 2012 Oct 15; 189(8):4060-8. PMID: 22984078.
      Citations: 67     Fields:    Translation:AnimalsCells
    18. Hole CR, Wormley FL. Vaccine and immunotherapeutic approaches for the prevention of cryptococcosis: lessons learned from animal models. Front Microbiol. 2012; 3:291. PMID: 22973262.
      Citations:    
    19. Steele C, Wormley FL. Immunology of fungal infections: lessons learned from animal models. Curr Opin Microbiol. 2012 Aug; 15(4):413-9. PMID: 22763286.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Walraven CJ, Gerstein W, Hardison SE, Wormley F, Lockhart SR, Harris JR, Fothergill A, Wickes B, Gober-Wilcox J, Massie L, Ku TS, Firacative C, Meyer W, Lee SA. Fatal disseminated Cryptococcus gattii infection in New Mexico. PLoS One. 2011; 6(12):e28625. PMID: 22194869.
      Citations: 25     Fields:    Translation:HumansAnimals
    21. Wozniak KL, Hardison S, Olszewski M, Wormley FL. Induction of protective immunity against cryptococcosis. Mycopathologia. 2012 Jun; 173(5-6):387-94. PMID: 22143898.
      Citations: 16     Fields:    Translation:HumansAnimals
    22. Chaturvedi AK, Lazzell AL, Saville SP, Wormley FL, Monteagudo C, Lopez-Ribot JL. Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease. PLoS One. 2011; 6(5):e20449. PMID: 21633704.
      Citations: 4     Fields:    Translation:AnimalsCells
    23. Wozniak KL, Young ML, Wormley FL. Protective immunity against experimental pulmonary cryptococcosis in T cell-depleted mice. Clin Vaccine Immunol. 2011 May; 18(5):717-23. PMID: 21450975.
      Citations: 44     Fields:    Translation:AnimalsCells
    24. Wozniak KL, Hardison SE, Kolls JK, Wormley FL. Role of IL-17A on resolution of pulmonary C. neoformans infection. PLoS One. 2011 Feb 17; 6(2):e17204. PMID: 21359196.
      Citations: 65     Fields:    Translation:AnimalsCells
    25. Hardison SE, Wozniak KL, Kolls JK, Wormley FL. Interleukin-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection. Infect Immun. 2010 Dec; 78(12):5341-51. PMID: 20921149.
      Citations: 44     Fields:    Translation:AnimalsCells
    26. Hardison SE, Ravi S, Wozniak KL, Young ML, Olszewski MA, Wormley FL. Pulmonary infection with an interferon-gamma-producing Cryptococcus neoformans strain results in classical macrophage activation and protection. Am J Pathol. 2010 Feb; 176(2):774-85. PMID: 20056835.
      Citations: 82     Fields:    Translation:AnimalsCellsPHPublic Health
    27. Wozniak KL, Ravi S, Macias S, Young ML, Olszewski MA, Steele C, Wormley FL. Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis. PLoS One. 2009 Sep 03; 4(9):e6854. PMID: 19727388.
      Citations: 68     Fields:    Translation:AnimalsCells
    28. Young M, Macias S, Thomas D, Wormley FL. A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins. Proteomics. 2009 May; 9(9):2578-88. PMID: 19343717.
      Citations: 21     Fields:    Translation:AnimalsPHPublic Health
    29. Ravi S, Pierce C, Witt C, Wormley FL. Biofilm formation by Cryptococcus neoformans under distinct environmental conditions. Mycopathologia. 2009 Jun; 167(6):307-14. PMID: 19130292.
      Citations: 18     Fields:    Translation:Animals
    30. Pierce CG, Uppuluri P, Tristan AR, Wormley FL, Mowat E, Ramage G, Lopez-Ribot JL. A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing. Nat Protoc. 2008; 3(9):1494-500. PMID: 18772877.
      Citations: 360     Fields:    Translation:Animals
    31. Wormley FL, Perfect JR, Steele C, Cox GM. Protection against cryptococcosis by using a murine gamma interferon-producing Cryptococcus neoformans strain. Infect Immun. 2007 Mar; 75(3):1453-62. PMID: 17210668.
      Citations: 113     Fields:    Translation:Animals
    32. Wormley FL, Heinrich G, Miller JL, Perfect JR, Cox GM. Identification and characterization of an SKN7 homologue in Cryptococcus neoformans. Infect Immun. 2005 Aug; 73(8):5022-30. PMID: 16041017.
      Citations: 41     Fields:    Translation:AnimalsCells
    33. Wormley FL, Cox GM, Perfect JR. Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. Microb Pathog. 2005 Feb-Mar; 38(2-3):113-23. PMID: 15748813.
      Citations: 13     Fields:    Translation:AnimalsCells
    34. Wormley FL, Perfect JR. Immunology of infection caused by Cryptococcus neoformans. Methods Mol Med. 2005; 118:193-8. PMID: 15888944.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    35. Onyewu C, Wormley FL, Perfect JR, Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infect Immun. 2004 Dec; 72(12):7330-3. PMID: 15557662.
      Citations: 58     Fields:    Translation:Animals
    36. Wormley FL, Cutright J, Fidel PL. Multiple experimental designs to evaluate the role of T-cell-mediated immunity against experimental vaginal Candida albicans infection. Med Mycol. 2003 Oct; 41(5):401-9. PMID: 14653516.
      Citations: 7     Fields:    Translation:AnimalsCells
    37. Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J. Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryot Cell. 2003 Jun; 2(3):422-30. PMID: 12796287.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    38. Wozniak KL, Wormley FL, Fidel PL. Candida-specific antibodies during experimental vaginal candidiasis in mice. Infect Immun. 2002 Oct; 70(10):5790-9. PMID: 12228309.
      Citations: 16     Fields:    Translation:HumansAnimals
    39. Leigh JE, Steele C, Wormley F, Fidel PL. Salivary cytokine profiles in the immunocompetent individual with Candida-associated denture stomatitis. Oral Microbiol Immunol. 2002 Oct; 17(5):311-4. PMID: 12354213.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    40. C?rdenas-Freytag L, Steele C, Wormley FL, Cheng E, Clements JD, Fidel PL. Partial protection against experimental vaginal candidiasis after mucosal vaccination with heat-killed Candida albicans and the mucosal adjuvant LT(R192G). Med Mycol. 2002 Jun; 40(3):291-9. PMID: 12146759.
      Citations: 6     Fields:    Translation:AnimalsPHPublic Health
    41. Wormley FL, Steele C, Wozniak K, Fujihashi K, McGhee JR, Fidel PL. Resistance of T-cell receptor delta-chain-deficient mice to experimental Candida albicans vaginitis. Infect Immun. 2001 Nov; 69(11):7162-4. PMID: 11598094.
      Citations: 15     Fields:    Translation:AnimalsCells
    42. Wormley FL, Chaiban J, Fidel PL. Cell adhesion molecule and lymphocyte activation marker expression during experimental vaginal candidiasis. Infect Immun. 2001 Aug; 69(8):5072-9. PMID: 11447188.
      Citations: 12     Fields:    Translation:AnimalsCells
    43. Kelly KA, Gray HL, Walker JC, Rank RG, Wormley FL, Fidel PL. Chlamydia trachomatis infection does not enhance local cellular immunity against concurrent Candida vaginal infection. Infect Immun. 2001 May; 69(5):3451-4. PMID: 11292774.
      Citations: 4     Fields:    Translation:AnimalsCells
    44. Fidel PL, Wormley FL, Chaiban J, Chesson RR, Lounev V. Analysis of the CD4 protein on human vaginal T lymphocytes. Am J Reprod Immunol. 2001 Apr; 45(4):200-4. PMID: 11327546.
      Citations: 5     Fields:    Translation:HumansCells
    45. Wormley FL, Scott M, Luo W, Baker M, Chaiban J, Fidel PL. Evidence for a unique expression of CD4 on murine vaginal CD4+ cells. Immunology. 2000 Jul; 100(3):300-8. PMID: 10929051.
      Citations: 3     Fields:    Translation:Animals
    46. Fidel PL, Luo W, Steele C, Chabain J, Baker M, Wormley F. Analysis of vaginal cell populations during experimental vaginal candidiasis. Infect Immun. 1999 Jun; 67(6):3135-40. PMID: 10338532.
      Citations: 38     Fields:    Translation:AnimalsCells
    47. Leigh JE, Steele C, Wormley FL, Luo W, Clark RA, Gallaher W, Fidel PL. Th1/Th2 cytokine expression in saliva of HIV-positive and HIV-negative individuals: a pilot study in HIV-positive individuals with oropharyngeal candidiasis. J Acquir Immune Defic Syndr Hum Retrovirol. 1998 Dec 01; 19(4):373-80. PMID: 9833746.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
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