Macrophage Activation

"Macrophage Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.

Descriptor ID	D008262
MeSH Number(s)	G12.287.500
Concept/Terms	Macrophage Activation Macrophage Activation Activation, Macrophage Activations, Macrophage Macrophage Activations

Below are MeSH descriptors whose meaning is more general than "Macrophage Activation".

Biological Sciences [G]
Immune System Phenomena [G12]
Cytotoxicity, Immunologic [G12.287]
Macrophage Activation [G12.287.500]

Below are MeSH descriptors whose meaning is related to "Macrophage Activation".

Below are MeSH descriptors whose meaning is more specific than "Macrophage Activation".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Macrophage Activation" by people in this website by year, and whether "Macrophage Activation" was a major or minor topic of these publications.

Bar chart showing 52 publications over 21 distinct years, with a maximum of 5 publications in 2002 and 2010 and 2015

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2002	1	4	5
2003	2	0	2
2004	0	3	3
2005	0	1	1
2007	0	2	2
2008	0	1	1
2009	1	0	1
2010	4	1	5
2011	2	2	4
2012	2	1	3
2013	2	1	3
2014	4	0	4
2015	1	4	5
2016	1	0	1
2017	1	0	1
2018	1	1	2
2019	1	0	1
2020	1	2	3
2021	0	2	2
2024	1	0	1
2026	1	1	2

Below are the most recent publications written about "Macrophage Activation" by people in Profiles.

Shake EP, Vargas Santos G, Sivaraman V. Alcohol and Cannabinoids Differentially Regulate Macrophage Polarization, with Co-Exposure Producing an Antagonistic Immunomodulatory Effect. Int J Mol Sci. 2026 Apr 30; 27(9).

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da Silva RAG, Tien BYQ, Kao PHN, Antypas H, Celik C, Tan AZC, Ismail MH, Hu G, Chong KKL, Thibault G, Chen J, Kline KA. Enterococcus faecalis-derived lactic acid suppresses macrophage activation to facilitate persistent and polymicrobial wound infections. Cell Host Microbe. 2026 Feb 11; 34(2):245-262.e8.

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Ryan AK, Rahman S, Williams RM. Optical Aptamer-Based Cytokine Nanosensor Detects Macrophage Activation by Bacterial Toxins. ACS Sens. 2024 07 26; 9(7):3697-3706.

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Lv LL, Wang C, Li ZL, Cao JY, Zhong X, Feng Y, Chen J, Tang TT, Ni HF, Wu QL, Wang B, Lan HY, Liu BC. SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury. Cell Death Dis. 2021 09 23; 12(10):866.

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Zhang R, Jones MM, Parker D, Dornsife RE, Wymer N, Onyenwoke RU, Sivaraman V. Acute vaping exacerbates microbial pneumonia due to calcium (Ca2+) dysregulation. PLoS One. 2021; 16(8):e0256166.

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Kurtz JR, Nieves W, Bauer DL, Israel KE, Adcox HE, Gunn JS, Morici LA, McLachlan JB. Salmonella Persistence and Host Immunity Are Dictated by the Anatomical Microenvironment. Infect Immun. 2020 07 21; 88(8).

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Zhao Y, Chang Z, Zhao G, Lu H, Xiong W, Liang W, Wang H, Villacorta L, Garcia-Barrio MT, Zhu T, Guo Y, Fan Y, Chang L, Schopfer FJ, Freeman BA, Zhang J, Chen YE. Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy. Cardiovasc Drugs Ther. 2021 10; 35(5):939-951.

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Nath N, Kashfi K. Tumor associated macrophages and 'NO'. Biochem Pharmacol. 2020 06; 176:113899.

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Campuzano A, Castro-Lopez N, Martinez AJ, Olszewski MA, Ganguly A, Leopold Wager C, Hung CY, Wormley FL. CARD9 Is Required for Classical Macrophage Activation and the Induction of Protective Immunity against Pulmonary Cryptococcosis. mBio. 2020 01 07; 11(1).

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Lv LL, Feng Y, Wu M, Wang B, Li ZL, Zhong X, Wu WJ, Chen J, Ni HF, Tang TT, Tang RN, Lan HY, Liu BC. Exosomal miRNA-19b-3p of tubular epithelial cells promotes M1 macrophage activation in kidney injury. Cell Death Differ. 2020 01; 27(1):210-226.

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