alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
"alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.
| Descriptor ID |
D018350
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| MeSH Number(s) |
D03.383.129.385.025
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
Below are MeSH descriptors whose meaning is more specific than "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid".
This graph shows the total number of publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in this website by year, and whether "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1995 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2012 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid" by people in Profiles.
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Harms JE, Benveniste M, Kessler M, Stone LM, Arai AC, Partin KM. A charge-inverting mutation in the "linker" region of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators. J Biol Chem. 2014 Apr 11; 289(15):10702-10714.
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Jim?nez-Rivera CA, Figueroa J, V?zquez-Torres R, V?lez-Hernandez ME, Schwarz D, Vel?squez-Martinez MC, Arencibia-Albite F. Presynaptic inhibition of glutamate transmission by a2 receptors in the VTA. Eur J Neurosci. 2012 May; 35(9):1406-15.
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Benveniste M, Wilhelm J, Dingledine RJ, Mott DD. Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors. Brain Res. 2010 Sep 17; 1352:61-9.
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Bellinger FP, Fox BK, Chan WY, Davis LK, Andres MA, Hirano T, Grau EG, Cooke IM. Ionotropic glutamate receptor activation increases intracellular calcium in prolactin-releasing cells of the adenohypophysis. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1188-96.
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Shao XM, Ge Q, Feldman JL. Modulation of AMPA receptors by cAMP-dependent protein kinase in preB?tzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J Physiol. 2003 Mar 01; 547(Pt 2):543-53.
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Wang XM, Zhang KM, Long LO, Mokha SS. Orphanin FQ (nociceptin) modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli, and blocks the substance P-induced facilitation of N-methyl-D-aspartate-evoked responses. Neuroscience. 1999; 93(2):703-12.
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Porter JT, McCarthy KD. GFAP-positive hippocampal astrocytes in situ respond to glutamatergic neuroligands with increases in [Ca2+]i. Glia. 1995 Feb; 13(2):101-12.
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K?nig N, Serrano P, Drian MJ. AMPA elicits long-lasting, partly hypothermia-sensitive calcium responses in acutely dissociated or cultured embryonic brainstem cells. Neurochem Int. 1994 May; 24(5):459-71.