Receptors, N-Methyl-D-Aspartate
"Receptors, N-Methyl-D-Aspartate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.
| Descriptor ID |
D016194
|
| MeSH Number(s) |
D12.776.157.530.400.400.500.500 D12.776.543.550.450.500.200.500 D12.776.543.585.400.500.200.500 D12.776.543.750.720.200.450.400.500
|
| Concept/Terms |
Receptors, N-Methyl-D-Aspartate- Receptors, N-Methyl-D-Aspartate
- Receptors, N Methyl D Aspartate
- N-Methyl-D-Aspartate Receptors
- N Methyl D Aspartate Receptors
- NMDA Receptors
- Receptors, N-Methylaspartate
- Receptors, N Methylaspartate
- Receptors, NMDA
- NMDA Receptor-Ionophore Complex
- NMDA Receptor Ionophore Complex
- N-Methylaspartate Receptors
- N Methylaspartate Receptors
|
Below are MeSH descriptors whose meaning is more general than "Receptors, N-Methyl-D-Aspartate".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Carrier Proteins [D12.776.157]
- Membrane Transport Proteins [D12.776.157.530]
- Ion Channels [D12.776.157.530.400]
- Ligand-Gated Ion Channels [D12.776.157.530.400.400]
- Receptors, Ionotropic Glutamate [D12.776.157.530.400.400.500]
- Receptors, N-Methyl-D-Aspartate [D12.776.157.530.400.400.500.500]
- Membrane Proteins [D12.776.543]
- Membrane Glycoproteins [D12.776.543.550]
- Ion Channels [D12.776.543.550.450]
- Ligand-Gated Ion Channels [D12.776.543.550.450.500]
- Receptors, Ionotropic Glutamate [D12.776.543.550.450.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.550.450.500.200.500]
- Membrane Transport Proteins [D12.776.543.585]
- Ion Channels [D12.776.543.585.400]
- Ligand-Gated Ion Channels [D12.776.543.585.400.500]
- Receptors, Ionotropic Glutamate [D12.776.543.585.400.500.200]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.585.400.500.200.500]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Amino Acid [D12.776.543.750.720.200]
- Receptors, Glutamate [D12.776.543.750.720.200.450]
- Receptors, Ionotropic Glutamate [D12.776.543.750.720.200.450.400]
- Receptors, N-Methyl-D-Aspartate [D12.776.543.750.720.200.450.400.500]
Below are MeSH descriptors whose meaning is more specific than "Receptors, N-Methyl-D-Aspartate".
This graph shows the total number of publications written about "Receptors, N-Methyl-D-Aspartate" by people in this website by year, and whether "Receptors, N-Methyl-D-Aspartate" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 3 | 6 |
| 1995 | 4 | 0 | 4 |
| 1996 | 3 | 2 | 5 |
| 1997 | 1 | 0 | 1 |
| 1998 | 2 | 1 | 3 |
| 1999 | 4 | 1 | 5 |
| 2000 | 5 | 2 | 7 |
| 2001 | 2 | 2 | 4 |
| 2002 | 8 | 3 | 11 |
| 2003 | 4 | 3 | 7 |
| 2004 | 0 | 5 | 5 |
| 2005 | 4 | 2 | 6 |
| 2006 | 6 | 3 | 9 |
| 2007 | 1 | 2 | 3 |
| 2008 | 3 | 0 | 3 |
| 2009 | 2 | 2 | 4 |
| 2010 | 1 | 1 | 2 |
| 2011 | 2 | 1 | 3 |
| 2013 | 2 | 1 | 3 |
| 2015 | 1 | 1 | 2 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 0 | 3 | 3 |
| 2019 | 1 | 0 | 1 |
| 2020 | 2 | 0 | 2 |
| 2022 | 1 | 1 | 2 |
To return to the timeline,
click here.
Below are the most recent publications written about "Receptors, N-Methyl-D-Aspartate" by people in Profiles.
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Xie M, Leng T, Maysami S, Pearson A, Simon R, Xiong ZG, Meller R. Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules. 2022 09 01; 12(9).
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Ferrer-Acosta Y, Rodriguez-Mass? S, P?rez D, Eterovic VA, Ferchmin PA, Martins AH. Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult. Toxicol In Vitro. 2022 Oct; 84:105453.
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Toropova AP, Toropov AA, Leszczynska D, Leszczynski J. How the CORAL software can be used to select compounds for efficient treatment of neurodegenerative diseases? Toxicol Appl Pharmacol. 2020 12 01; 408:115276.
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Zhang ZH, Chen C, Jia SZ, Cao XC, Liu M, Tian J, Hoffmann PR, Xu HX, Ni JZ, Song GL. Selenium Restores Synaptic Deficits by Modulating NMDA Receptors and Selenoprotein K in an Alzheimer's Disease Model. Antioxid Redox Signal. 2021 10 10; 35(11):863-884.
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Soler-Cede?o O, Torres-Rodr?guez O, Bernard F, Maldonado L, Hern?ndez A, Porter JT. Plasticity of NMDA Receptors at Ventral Hippocampal Synapses in the Infralimbic Cortex Regulates Cued Fear. eNeuro. 2019 Mar-Apr; 6(2).
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Offei SD, Arman HD, Baig MO, Chavez LS, Paladini CA, Yoshimoto FK. Chemical synthesis of 7-oxygenated 12a-hydroxy steroid derivatives to enable the biochemical characterization of cytochrome P450 8B1, the oxysterol 12a-hydroxylase enzyme implicated in cardiovascular health and obesity. Steroids. 2018 12; 140:185-195.
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Rodr?guez G, Chakraborty D, Schrode KM, Saha R, Uribe I, Lauer AM, Lee HK. Cross-Modal Reinstatement of Thalamocortical Plasticity Accelerates Ocular Dominance Plasticity in Adult Mice. Cell Rep. 2018 09 25; 24(13):3433-3440.e4.
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Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, Benveniste M, Davis RJ, Todorovic C. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018 04 11; 38(15):3708-3728.
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Beaudoin GMJ, Gomez JA, Perkins J, Bland JL, Petko AK, Paladini CA. Cocaine Selectively Reorganizes Excitatory Inputs to Substantia Nigra Pars Compacta Dopamine Neurons. J Neurosci. 2018 01 31; 38(5):1151-1159.
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Otis JM, Mueller D. Reversal of Cocaine-Associated Synaptic Plasticity in Medial Prefrontal Cortex Parallels Elimination of Memory Retrieval. Neuropsychopharmacology. 2017 Sep; 42(10):2000-2010.