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Frederick P. Bellinger, PhD

Title
Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentCell and Molecular Biology
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921512
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    Our research currently investigates the different roles of members of the selenoprotein family in brain function and neurological disorders. Selenoproteins are proteins that contain the strong antioxidant element selenium in the form of selenocysteine, 21st amino acid. We are examining the roles of these proteins in neuron physiology, synaptic plasticity, and in neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. Our ongoing research indicates that selenoproteins may be very important for synaptic development and function, and have found correlations of specific selenoproteins with neurodegenerative disorders.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kiyohara ACP, Torres DJ, Hagiwara A, Pak J, Rueli RHLH, Shuttleworth CWR, Bellinger FP. Selenoprotein P Regulates Synaptic Zinc and Reduces Tau Phosphorylation. Front Nutr. 2021; 8:683154. PMID: 34277682.
      Citations:    
    2. Torres DJ, Yorgason JT, Andres MA, Bellinger FP. Methamphetamine Exposure During Development Causes Lasting Changes to Mesolimbic Dopamine Signaling in Mice. Cell Mol Neurobiol. 2022 Oct; 42(7):2433-2438. PMID: 34138411.
      Citations: 2     Fields:    Translation:HumansAnimals
    3. Torres DJ, Yorgason JT, Mitchell CC, Hagiwara A, Andres MA, Kurokawa S, Steffensen SC, Bellinger FP. Selenoprotein P Modulates Methamphetamine Enhancement of Vesicular Dopamine Release in Mouse Nucleus Accumbens Via Dopamine D2 Receptors. Front Neurosci. 2021; 15:631825. PMID: 33927588.
      Citations:    
    4. Hedges DM, Obray JD, Yorgason JT, Jang EY, Weerasekara VK, Uys JD, Bellinger FP, Steffensen SC. Methamphetamine Induces Dopamine Release in the Nucleus Accumbens Through a Sigma Receptor-Mediated Pathway. Neuropsychopharmacology. 2018 05; 43(6):1405-1414. PMID: 29185481.
      Citations: 26     Fields:    Translation:Animals
    5. Rueli RH, Torres DJ, Dewing AS, Kiyohara AC, Barayuga SM, Bellinger MT, Uyehara-Lock JH, White LR, Moreira PI, Berry MJ, Perry G, Bellinger FP. Selenoprotein S Reduces Endoplasmic Reticulum Stress-Induced Phosphorylation of Tau: Potential Role in Selenate Mitigation of Tau Pathology. J Alzheimers Dis. 2017; 55(2):749-762. PMID: 27802219.
      Citations: 16     Fields:    Translation:HumansCells
    6. Andres MA, Cooke IM, Bellinger FP, Berry MJ, Zaporteza MM, Rueli RH, Barayuga SM, Chang L. Methamphetamine acutely inhibits voltage-gated calcium channels but chronically up-regulates L-type channels. J Neurochem. 2015 Jul; 134(1):56-65. PMID: 25807982.
      Citations: 8     Fields:    Translation:HumansCells
    7. Berry MJ, Astern J, Bellinger F, Brampton C, Cann R, Gerschenson M, Haymer D, James NG, Jameson DM, LeSaux O, Hoffmann PR, Nichols R, Pitts M, Seale L, Seifried S, Stokes AJ, Todorovic C. Medical school hotline: the research mission of the cell and molecular biology department and program at the john a. Burns school of medicine. Hawaii J Med Public Health. 2015 Apr; 74(4):150-3. PMID: 25954603.
      Citations:    Fields:    Translation:Humans
    8. Rueli RH, Parubrub AC, Dewing AS, Hashimoto AC, Bellinger MT, Weeber EJ, Uyehara-Lock JH, White LR, Berry MJ, Bellinger FP. Increased selenoprotein P in choroid plexus and cerebrospinal fluid in Alzheimer's disease brain. J Alzheimers Dis. 2015; 44(2):379-83. PMID: 25298198.
      Citations: 13     Fields:    Translation:Humans
    9. Lawrence JL, Tong M, Alfulaij N, Sherrin T, Contarino M, White MM, Bellinger FP, Todorovic C, Nichols RA. Regulation of presynaptic Ca2+, synaptic plasticity and contextual fear conditioning by a N-terminal ?-amyloid fragment. J Neurosci. 2014 Oct 22; 34(43):14210-8. PMID: 25339735.
      Citations: 27     Fields:    Translation:AnimalsCells
    10. Pillai R, Uyehara-Lock JH, Bellinger FP. Selenium and selenoprotein function in brain disorders. IUBMB Life. 2014 Apr; 66(4):229-39. PMID: 24668686.
      Citations: 62     Fields:    Translation:HumansAnimals
    11. Kurokawa S, Bellinger FP, Hill KE, Burk RF, Berry MJ. Isoform-specific binding of selenoprotein P to the ?-propeller domain of apolipoprotein E receptor 2 mediates selenium supply. J Biol Chem. 2014 Mar 28; 289(13):9195-207. PMID: 24532792.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    12. Miki T, Yokoyama T, Kusaka T, Suzuki S, Ohta K, Warita K, Wang ZY, Ueki M, Sumitani K, Bellinger FP, Tamai M, Liu JQ, Yakura T, Takeuchi Y. Early postnatal repeated maternal deprivation causes a transient increase in OMpg and BDNF in rat cerebellum suggesting precocious myelination. J Neurol Sci. 2014 Jan 15; 336(1-2):62-7. PMID: 24157309.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Raman AV, Pitts MW, Seyedali A, Hashimoto AC, Bellinger FP, Berry MJ. Selenoprotein W expression and regulation in mouse brain and neurons. Brain Behav. 2013 Sep; 3(5):562-74. PMID: 24392277.
      Citations: 10     Fields:    
    14. Barayuga SM, Pang X, Andres MA, Panee J, Bellinger FP. Methamphetamine decreases levels of glutathione peroxidases 1 and 4 in SH-SY5Y neuronal cells: protective effects of selenium. Neurotoxicology. 2013 Jul; 37:240-6. PMID: 23721877.
      Citations: 20     Fields:    Translation:HumansCells
    15. Raman AV, Chou VP, Atienza-Duyanen J, Di Monte DA, Bellinger FP, Manning-Bog AB. Evidence of oxidative stress in young and aged DJ-1-deficient mice. FEBS Lett. 2013 May 21; 587(10):1562-70. PMID: 23587484.
      Citations: 8     Fields:    Translation:AnimalsCells
    16. Dewing AS, Rueli RH, Robles MJ, Nguyen-Wu ED, Zeyda T, Berry MJ, Bellinger FP. Expression and regulation of mouse selenoprotein P transcript variants differing in non-coding RNA. RNA Biol. 2012 Nov; 9(11):1361-9. PMID: 23064117.
      Citations: 13     Fields:    Translation:AnimalsCells
    17. Seale LA, Hashimoto AC, Kurokawa S, Gilman CL, Seyedali A, Bellinger FP, Raman AV, Berry MJ. Disruption of the selenocysteine lyase-mediated selenium recycling pathway leads to metabolic syndrome in mice. Mol Cell Biol. 2012 Oct; 32(20):4141-54. PMID: 22890841.
      Citations: 57     Fields:    Translation:Animals
    18. Raman AV, Pitts MW, Seyedali A, Hashimoto AC, Seale LA, Bellinger FP, Berry MJ. Absence of selenoprotein P but not selenocysteine lyase results in severe neurological dysfunction. Genes Brain Behav. 2012 Jul; 11(5):601-13. PMID: 22487427.
      Citations: 28     Fields:    Translation:Animals
    19. Bellinger FP, Raman AV, Rueli RH, Bellinger MT, Dewing AS, Seale LA, Andres MA, Uyehara-Lock JH, White LR, Ross GW, Berry MJ. Changes in selenoprotein P in substantia nigra and putamen in Parkinson's disease. J Parkinsons Dis. 2012; 2(2):115-26. PMID: 23268326.
      Citations: 21     Fields:    Translation:Humans
    20. Bellinger FP, Bellinger MT, Seale LA, Takemoto AS, Raman AV, Miki T, Manning-Bog AB, Berry MJ, White LR, Ross GW. Glutathione Peroxidase 4 is associated with Neuromelanin in Substantia Nigra and Dystrophic Axons in Putamen of Parkinson's brain. Mol Neurodegener. 2011 Jan 21; 6(1):8. PMID: 21255396.
      Citations: 55     Fields:    
    21. Reeves MA, Bellinger FP, Berry MJ. The neuroprotective functions of selenoprotein M and its role in cytosolic calcium regulation. Antioxid Redox Signal. 2010 Apr 01; 12(7):809-18. PMID: 19769485.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    22. Takemoto AS, Berry MJ, Bellinger FP. Role of selenoprotein P in Alzheimer's disease. Ethn Dis. 2010; 20(1 Suppl 1):S1-92-5. PMID: 20521393.
      Citations: 17     Fields:    Translation:Humans
    23. Bellinger FP, Raman AV, Reeves MA, Berry MJ. Regulation and function of selenoproteins in human disease. Biochem J. 2009 Jul 29; 422(1):11-22. PMID: 19627257.
      Citations: 135     Fields:    Translation:Humans
    24. Andres MA, Baptista NC, Efird JT, Ogata KK, Bellinger FP, Zeyda T. Depletion of SK1 channel subunits leads to constitutive insulin secretion. FEBS Lett. 2009 Jan 22; 583(2):369-76. PMID: 19101546.
      Citations: 6     Fields:    Translation:AnimalsCells
    25. Bellinger FP, He QP, Bellinger MT, Lin Y, Raman AV, White LR, Berry MJ. Association of selenoprotein p with Alzheimer's pathology in human cortex. J Alzheimers Dis. 2008 Nov; 15(3):465-72. PMID: 18997300.
      Citations: 34     Fields:    Translation:HumansCells
    26. Bellinger FP, Fox BK, Chan WY, Davis LK, Andres MA, Hirano T, Grau EG, Cooke IM. Ionotropic glutamate receptor activation increases intracellular calcium in prolactin-releasing cells of the adenohypophysis. Am J Physiol Endocrinol Metab. 2006 Dec; 291(6):E1188-96. PMID: 16822959.
      Citations: 2     Fields:    Translation:AnimalsCells
    27. Bellinger FP, Davidson MS, Bedi KS, Wilce PA. Ethanol prevents NMDA receptor reduction by maternal separation in neonatal rat hippocampus. Brain Res. 2006 Jan 05; 1067(1):154-7. PMID: 16359646.
      Citations: 1     Fields:    Translation:Animals
    28. Bark C, Bellinger FP, Kaushal A, Mathews JR, Partridge LD, Wilson MC. Developmentally regulated switch in alternatively spliced SNAP-25 isoforms alters facilitation of synaptic transmission. J Neurosci. 2004 Oct 06; 24(40):8796-805. PMID: 15470145.
      Citations: 50     Fields:    Translation:AnimalsCells
    29. Fan L, Bellinger F, Ge YL, Wilce P. Genetic study of alcoholism and novel gene expression in the alcoholic brain. Addict Biol. 2004 Mar; 9(1):11-8. PMID: 15203434.
      Citations: 9     Fields:    Translation:HumansCells
    30. Bellinger FP, Davidson MS, Bedi KS, Wilce PA. Neonatal ethanol exposure reduces AMPA but not NMDA receptor levels in the rat neocortex. Brain Res Dev Brain Res. 2002 May 30; 136(1):77-84. PMID: 12036520.
      Citations: 20     Fields:    Translation:Animals
    31. Bellinger FP, Wilce PA, Bedi KS, Wilson P. Long-lasting synaptic modification in the rat hippocampus resulting from NMDA receptor blockade during development. Synapse. 2002 Feb; 43(2):95-101. PMID: 11754487.
      Citations: 9     Fields:    Translation:AnimalsCells
    32. Bellinger FP, Bedi KS, Wilson P, Wilce PA. Ethanol exposure during the third trimester equivalent results in long-lasting decreased synaptic efficacy but not plasticity in the CA1 region of the rat hippocampus. Synapse. 1999 Jan; 31(1):51-8. PMID: 10025683.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    33. Gold LH, Heyser CJ, Roberts AJ, Henriksen SJ, Steffensen SC, Siggins GR, Bellinger FP, Chiang CS, Powell HC, Masliah E, Campbell IL. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice. Adv Exp Med Biol. 1996; 402:199-205. PMID: 8787661.
      Citations: 2     Fields:    Translation:Animals
    34. Bellinger FP, Madamba SG, Campbell IL, Siggins GR. Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6. Neurosci Lett. 1995 Sep 29; 198(2):95-8. PMID: 8592650.
      Citations: 49     Fields:    Translation:Animals
    35. Bellinger FP, Madamba S, Siggins GR. Interleukin 1 beta inhibits synaptic strength and long-term potentiation in the rat CA1 hippocampus. Brain Res. 1993 Nov 19; 628(1-2):227-34. PMID: 8313151.
      Citations: 146     Fields:    Translation:AnimalsCells
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