Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.

Descriptor ID	D014402
MeSH Number(s)	C04.445.810 C04.651.800 C04.700.632 C10.500.507.400.750 C10.562.850 C10.574.500.865 C16.131.666.507.400.750 C16.320.400.880 C16.320.700.636
Concept/Terms	Tuberous Sclerosis Tuberous Sclerosis Sclerosis, Tuberous Tuberous Sclerosis Complex Bourneville Syndrome Syndrome, Bourneville Bourneville's Disease Bourneville's Syndrome Syndrome, Bourneville's Bourneville-Pringle Disease Bourneville Pringle Disease Disease, Bourneville-Pringle Bourneville-Pringle's Disease Bourneville Pringle's Disease Bourneville-Pringles Disease Disease, Bourneville-Pringle's Cerebral Sclerosis Cerebral Scleroses Sclerosis, Cerebral Epiloia Phacomatosis, Bourneville Bourneville Phacomatosis Phakomatosis, Bourneville Sclerosis Tuberosa Tuberose Sclerosis Sclerosis, Tuberose Bourneville Disease Bourneville Phakomatosis Adenoma Sebaceum Adenoma Sebaceum

Below are MeSH descriptors whose meaning is more general than "Tuberous Sclerosis".

Below are MeSH descriptors whose meaning is related to "Tuberous Sclerosis".

Below are MeSH descriptors whose meaning is more specific than "Tuberous Sclerosis".