S-Phase Kinase-Associated Proteins

"S-Phase Kinase-Associated Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

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A family of structurally-related proteins that were originally identified by their ability to complex with cyclin proteins (CYCLINS). They share a common domain that binds specifically to F-BOX MOTIFS. They take part in SKP CULLIN F-BOX PROTEIN LIGASES, where they can bind to a variety of F-BOX PROTEINS.

Descriptor ID	D044786
MeSH Number(s)	D12.776.157.743
Concept/Terms	S-Phase Kinase-Associated Proteins S-Phase Kinase-Associated Proteins Kinase-Associated Proteins, S-Phase Proteins, S-Phase Kinase-Associated S Phase Kinase Associated Proteins Skp Domain Protein S-Phase Kinase Associated Protein S Phase Kinase Associated Protein Skp Domain Proteins Skp2 Proteins Skp2 Proteins p45(SKP2) Protein p45(SKP2) Skp2 Protein p45 SKP2 SKP2, p45 SCF(SKP2) Skp1 Proteins Skp1 Proteins p19(SKP1) Protein Skp1 Protein p19 SKP1 SKP1, p19

Below are MeSH descriptors whose meaning is more general than "S-Phase Kinase-Associated Proteins".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
S-Phase Kinase-Associated Proteins [D12.776.157.743]

Below are MeSH descriptors whose meaning is related to "S-Phase Kinase-Associated Proteins".

Below are MeSH descriptors whose meaning is more specific than "S-Phase Kinase-Associated Proteins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "S-Phase Kinase-Associated Proteins" by people in this website by year, and whether "S-Phase Kinase-Associated Proteins" was a major or minor topic of these publications.

Bar chart showing 11 publications over 10 distinct years, with a maximum of 2 publications in 2008

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2006	1	0	1
2008	1	1	2
2009	1	0	1
2010	1	0	1
2012	1	0	1
2013	1	0	1
2015	1	0	1
2016	1	0	1
2021	0	1	1
2024	1	0	1

Below are the most recent publications written about "S-Phase Kinase-Associated Proteins" by people in Profiles.

Brown LK, Kanagasabai T, Li G, Celada SI, Rumph JT, Adunyah SE, Stewart LV, Chen Z. Co-targeting SKP2 and KDM5B inhibits prostate cancer progression by abrogating AKT signaling with induction of senescence and apoptosis. Prostate. 2024 Jun; 84(9):877-887.

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Li X, Gera L, Zhang S, Chen Y, Lou L, Wilson LM, Xie ZR, Sautto G, Liu D, Danaher A, Mamouni K, Yang Y, Du Y, Fu H, Kucuk O, Osunkoya AO, Zhou J, Wu D. Pharmacological inhibition of noncanonical EED-EZH2 signaling overcomes chemoresistance in prostate cancer. Theranostics. 2021; 11(14):6873-6890.

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Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z. SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Oncogene. 2017 03; 36(10):1364-1373.

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Lu W, Liu S, Li B, Xie Y, Adhiambo C, Yang Q, Ballard BR, Nakayama KI, Matusik RJ, Chen Z. SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination. Oncotarget. 2015 Jan 20; 6(2):771-88.

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Li B, Lu W, Yang Q, Yu X, Matusik RJ, Chen Z. Skp2 regulates androgen receptor through ubiquitin-mediated degradation independent of Akt/mTOR pathways in prostate cancer. Prostate. 2014 Apr; 74(4):421-32.

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Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93.

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Lin HK, Chen Z, Wang G, Nardella C, Lee SW, Chan CH, Chan CH, Yang WL, Wang J, Egia A, Nakayama KI, Cordon-Cardo C, Teruya-Feldstein J, Pandolfi PP. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature. 2010 Mar 18; 464(7287):374-9.

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Lin HK, Wang G, Chen Z, Teruya-Feldstein J, Liu Y, Chan CH, Yang WL, Erdjument-Bromage H, Nakayama KI, Nimer S, Tempst P, Pandolfi PP. Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol. 2009 Apr; 11(4):420-32.

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Yang Y, Kitagaki J, Wang H, Hou DX, Perantoni AO. Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 2009 Jan; 100(1):24-8.

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Miranda-Carboni GA, Krum SA, Yee K, Nava M, Deng QE, Pervin S, Collado-Hidalgo A, Galic Z, Zack JA, Nakayama K, Nakayama KI, Lane TF. A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev. 2008 Nov 15; 22(22):3121-34.

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