A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)

Descriptor ID	D006816
MeSH Number(s)	C10.228.140.079.545 C10.228.140.380.278 C10.228.662.262.249.750 C10.574.500.497 C16.320.400.430 F03.615.250.400 F03.615.400.390
Concept/Terms	Huntington Disease Huntington Disease Huntington Chorea Chorea, Huntington Huntington's Disease Chronic Progressive Hereditary Chorea (Huntington) Huntington Chronic Progressive Hereditary Chorea Progressive Chorea, Chronic Hereditary (Huntington) Progressive Chorea, Hereditary, Chronic (Huntington) Huntington's Chorea Chorea, Huntington's Chorea, Chronic Progressive Hereditary (Huntington) Huntington Disease, Late Onset Huntington Disease, Late Onset Late-Onset Huntington Disease Huntington Disease, Late-Onset Late Onset Huntington Disease Juvenile Huntington Disease Juvenile Huntington Disease Juvenile-Onset Huntington Disease Juvenile Onset Huntington Disease Huntington Disease, Juvenile-Onset Huntington Disease, Juvenile Onset Huntington Disease, Juvenile Akinetic-Rigid Variant of Huntington Disease Akinetic-Rigid Variant of Huntington Disease Akinetic Rigid Variant of Huntington Disease Huntington Disease, Akinetic-Rigid Variant Huntington Disease, Akinetic Rigid Variant

Below are MeSH descriptors whose meaning is more general than "Huntington Disease".

Below are MeSH descriptors whose meaning is related to "Huntington Disease".

Below are MeSH descriptors whose meaning is more specific than "Huntington Disease".