"Tretinoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
| Descriptor ID |
D014212
|
| MeSH Number(s) |
D02.455.326.271.665.202.495.818.500 D02.455.426.392.368.367.379.249.700.860.500 D02.455.849.131.495.818.800 D23.767.261.700.780
|
| Concept/Terms |
Tretinoin- Tretinoin
- Retinoic Acid
- Acid, Retinoic
- Vitamin A Acid
- Acid, Vitamin A
- all-trans-Retinoic Acid
- Acid, all-trans-Retinoic
- all trans Retinoic Acid
- trans-Retinoic Acid
- Acid, trans-Retinoic
- trans Retinoic Acid
|
Below are MeSH descriptors whose meaning is more general than "Tretinoin".
Below are MeSH descriptors whose meaning is more specific than "Tretinoin".
This graph shows the total number of publications written about "Tretinoin" by people in this website by year, and whether "Tretinoin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 3 | 1 | 4 |
| 1998 | 1 | 0 | 1 |
| 1999 | 2 | 0 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 0 | 3 | 3 |
| 2005 | 1 | 1 | 2 |
| 2006 | 0 | 2 | 2 |
| 2007 | 2 | 0 | 2 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2016 | 2 | 0 | 2 |
| 2017 | 0 | 1 | 1 |
| 2019 | 2 | 0 | 2 |
| 2020 | 0 | 1 | 1 |
| 2021 | 2 | 0 | 2 |
| 2023 | 1 | 0 | 1 |
To return to the timeline,
click here.
Below are the most recent publications written about "Tretinoin" by people in Profiles.
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Kirsanov O, Johnson TA, Niedenberger BA, Malachowski TN, Hale BJ, Chen Q, Lackford B, Wang J, Singh A, Schindler K, Hermann BP, Hu G, Geyer CB. Retinoic acid is dispensable for meiotic initiation but required for spermiogenesis in the mammalian testis. Development. 2023 07 15; 150(14).
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De La Rosa-Reyes V, Duprey-D?az MV, Blagburn JM, Blanco RE. Retinoic acid treatment recruits macrophages and increases axonal regeneration after optic nerve injury in the frog Rana pipiens. PLoS One. 2021; 16(11):e0255196.
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Suzuki S, McCarrey JR, Hermann BP. Differential RA responsiveness among subsets of mouse late progenitor spermatogonia. Reproduction. 2021 05 05; 161(6):645-655.
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Li AY, Kashanian SM, Hambley BC, Zacholski K, Baer MR, Duong VH, El Chaer F, Holtzman NG, Norsworthy KJ, Levis MJ, Smith BD, Kamangar F, Ghiaur G, Emadi A. Clustered incidence of adult acute promyelocytic leukemia in the vicinity of Baltimore. Leuk Lymphoma. 2020 11; 61(11):2743-2747.
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Kim SM, Yokoyama T, Ng D, Ulu F, Yamazaki Y. Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells. PLoS One. 2019; 14(11):e0224628.
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Velte EK, Niedenberger BA, Serra ND, Singh A, Roa-DeLaCruz L, Hermann BP, Geyer CB. Differential RA responsiveness directs formation of functionally distinct spermatogonial populations at the initiation of spermatogenesis in the mouse. Development. 2019 05 13; 146(12).
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Gundra UM, Girgis NM, Gonzalez MA, San Tang M, Van Der Zande HJP, Lin JD, Ouimet M, Ma LJ, Poles J, Vozhilla N, Fisher EA, Moore KJ, Loke P. Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation. Nat Immunol. 2017 06; 18(6):642-653.
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Duprey-D?az MV, Blagburn JM, Blanco RE. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS One. 2016; 11(9):e0162626.
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Duprey-D?az MV, Blagburn JM, Blanco RE. Optic nerve injury upregulates retinoic acid signaling in the adult frog visual system. J Chem Neuroanat. 2016 11; 77:80-92.
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Zhang C, Anderson A, Cole GJ. Analysis of crosstalk between retinoic acid and sonic hedgehog pathways following ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol. 2015 Dec; 103(12):1046-57.