"Thymidine Kinase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as a donor. (From Enzyme Nomenclature, 1992) EC 2.7.1.21.
| Descriptor ID |
D013937
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| MeSH Number(s) |
D08.811.913.696.620.750
|
| Concept/Terms |
Thymidine Kinase- Thymidine Kinase
- Kinase, Thymidine
- Deoxypyrimidine Kinase
- Kinase, Deoxypyrimidine
- Deoxythymidine Kinase
- Kinase, Deoxythymidine
|
Below are MeSH descriptors whose meaning is more general than "Thymidine Kinase".
Below are MeSH descriptors whose meaning is more specific than "Thymidine Kinase".
This graph shows the total number of publications written about "Thymidine Kinase" by people in this website by year, and whether "Thymidine Kinase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2002 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2009 | 2 | 0 | 2 |
| 2014 | 0 | 1 | 1 |
| 2017 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thymidine Kinase" by people in Profiles.
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Figliozzi RW, Chen F, Hsia SV. Reversing thyroid-hormone-mediated repression of a HSV-1 promoter via computationally guided mutagenesis. J Cell Sci. 2017 Nov 01; 130(21):3740-3748.
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Figliozzi RW, Chen F, Balish M, Ajavon A, Hsia SV. Thyroid hormone-dependent epigenetic suppression of herpes simplex virus-1 gene expression and viral replication in differentiated neuroendocrine cells. J Neurol Sci. 2014 Nov 15; 346(1-2):164-73.
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Vlashi E, Kim K, Lagadec C, Donna LD, McDonald JT, Eghbali M, Sayre JW, Stefani E, McBride W, Pajonk F. In vivo imaging, tracking, and targeting of cancer stem cells. J Natl Cancer Inst. 2009 Mar 04; 101(5):350-9.
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Bhattacharjee PS, Neumann DM, Hill JM. A human apolipoprotein E mimetic peptide effectively inhibits HSV-1 TK-positive and TK-negative acute epithelial keratitis in rabbits. Curr Eye Res. 2009 Feb; 34(2):99-102.
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Ebalunode JO, Ouyang Z, Liang J, Zheng W. Novel approach to structure-based pharmacophore search using computational geometry and shape matching techniques. J Chem Inf Model. 2008 Apr; 48(4):889-901.
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Lee HJ, Cooperwood JS, You Z, Ko DH. Prodrug and antedrug: two diametrical approaches in designing safer drugs. Arch Pharm Res. 2002 Apr; 25(2):111-36.
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Anderson LM, Swaminathan S, Zackon I, Tajuddin AK, Thimmapaya B, Weitzman SA. Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer. Gene Ther. 1999 May; 6(5):854-64.
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Lee EJ, Anderson LM, Thimmapaya B, Jameson JL. Targeted expression of toxic genes directed by pituitary hormone promoters: a potential strategy for adenovirus-mediated gene therapy of pituitary tumors. J Clin Endocrinol Metab. 1999 Feb; 84(2):786-94.
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Bond VC, Wold B. Poly-L-ornithine-mediated transformation of mammalian cells. Mol Cell Biol. 1987 Jun; 7(6):2286-93.