A charge-inverting mutation in the "linker" region of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators.

Harms JE, Benveniste M, Kessler M, Stone LM, Arai AC, Partin KM. A charge-inverting mutation in the "linker" region of a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators. J Biol Chem. 2014 Apr 11; 289(15):10702-10714.

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subject areas

Allosteric Site
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Animals
Binding Sites
Humans
Kinetics
Ligands
Models, Theoretical
Patch-Clamp Techniques
Point Mutation
Protein Binding
Protein Structure, Tertiary
Rats
Receptors, AMPA

authors with profiles

Morris Benveniste

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