Immunoglobulin Switch Region
"Immunoglobulin Switch Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.
| Descriptor ID |
D007134
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| MeSH Number(s) |
G05.360.340.024.340.137.430 G05.360.340.024.340.335.300.500
|
| Concept/Terms |
Immunoglobulin Switch Region- Immunoglobulin Switch Region
- Ig Switch Sequences
- Ig Switch Sequence
- Sequence, Ig Switch
- Sequences, Ig Switch
- Switch Sequence, Ig
- Switch Sequences, Ig
- Switch Region, Immunoglobulin
- Immunoglobulin Switch Regions
- Region, Immunoglobulin Switch
- Regions, Immunoglobulin Switch
- Switch Regions, Immunoglobulin
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Below are MeSH descriptors whose meaning is more general than "Immunoglobulin Switch Region".
Below are MeSH descriptors whose meaning is more specific than "Immunoglobulin Switch Region".
This graph shows the total number of publications written about "Immunoglobulin Switch Region" by people in this website by year, and whether "Immunoglobulin Switch Region" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Immunoglobulin Switch Region" by people in Profiles.
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Zheng S, Kusnadi A, Choi JE, Vuong BQ, Rhodes D, Chaudhuri J. NME proteins regulate class switch recombination. FEBS Lett. 2019 01; 593(1):80-87.
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Zeng X, Negrete GA, Kasmer C, Yang WW, Gearhart PJ. Absence of DNA polymerase eta reveals targeting of C mutations on the nontranscribed strand in immunoglobulin switch regions. J Exp Med. 2004 Apr 05; 199(7):917-24.
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Lyon CJ, Miranda GA, Piao JS, Aguilera RJ. Characterization of an endonuclease activity which preferentially cleaves the G-rich immunoglobulin switch repeat sequences. Mol Immunol. 1996 Feb; 33(2):157-69.