"Clotrimazole" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
| Descriptor ID |
D003022
|
| MeSH Number(s) |
D03.383.129.308.175
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Clotrimazole".
Below are MeSH descriptors whose meaning is more specific than "Clotrimazole".
This graph shows the total number of publications written about "Clotrimazole" by people in this website by year, and whether "Clotrimazole" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2007 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2016 | 1 | 0 | 1 |
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Below are the most recent publications written about "Clotrimazole" by people in Profiles.
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Iniguez E, Varela-Ramirez A, Mart?nez A, Torres CL, S?nchez-Delgado RA, Maldonado RA. Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis. Acta Trop. 2016 Dec; 164:402-410.
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Robles-Escajeda E, Mart?nez A, Varela-Ramirez A, S?nchez-Delgado RA, Aguilera RJ. Analysis of the cytotoxic effects of ruthenium-ketoconazole and ruthenium-clotrimazole complexes on cancer cells. Cell Biol Toxicol. 2013 Dec; 29(6):431-43.
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Mart?nez A, Carreon T, Iniguez E, Anzellotti A, S?nchez A, Tyan M, Sattler A, Herrera L, Maldonado RA, S?nchez-Delgado RA. Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells. J Med Chem. 2012 Apr 26; 55(8):3867-77.
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Ouellet H, Podust LM, de Montellano PR. Mycobacterium tuberculosis CYP130: crystal structure, biophysical characterization, and interactions with antifungal azole drugs. J Biol Chem. 2008 Feb 22; 283(8):5069-80.
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Brugnara C, Gee B, Armsby CC, Kurth S, Sakamoto M, Rifai N, Alper SL, Platt OS. Therapy with oral clotrimazole induces inhibition of the Gardos channel and reduction of erythrocyte dehydration in patients with sickle cell disease. J Clin Invest. 1996 Mar 01; 97(5):1227-34.