Leishmania major

"Leishmania major" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) of the Old World. Transmission is by Phlebotomus sandflies.

Descriptor ID	D018320
MeSH Number(s)	B01.268.475.868.488.405
Concept/Terms	Leishmania major Leishmania major Leishmania majors majors, Leishmania Leishmania leishmania major Leishmania leishmania majors leishmania major, Leishmania major, Leishmania leishmania majors, Leishmania leishmania Leishmania (Leishmania) major Leishmania tropica major Leishmania tropica majors majors, Leishmania tropica tropica major, Leishmania tropica majors, Leishmania

Below are MeSH descriptors whose meaning is more general than "Leishmania major".

Organisms [B]
Eukaryota [B01]
Euglenozoa [B01.268]
Kinetoplastida [B01.268.475]
Trypanosomatina [B01.268.475.868]
Leishmania [B01.268.475.868.488]
Leishmania major [B01.268.475.868.488.405]

Below are MeSH descriptors whose meaning is related to "Leishmania major".

Below are MeSH descriptors whose meaning is more specific than "Leishmania major".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Leishmania major" by people in this website by year, and whether "Leishmania major" was a major or minor topic of these publications.

Bar chart showing 19 publications over 14 distinct years, with a maximum of 2 publications in 2003 and 2010 and 2013 and 2015 and 2018

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2003	1	1	2
2004	1	0	1
2005	1	0	1
2006	1	0	1
2008	1	0	1
2010	2	0	2
2012	1	0	1
2013	2	0	2
2014	0	1	1
2015	2	0	2
2016	0	1	1
2017	1	0	1
2018	1	1	2
2025	1	0	1

Below are the most recent publications written about "Leishmania major" by people in Profiles.

Iniguez E, Rodriguez F, Husseneder C, Foil L, Maldonado RA. Ligand-lytic peptides for specific targeting of Leishmania major and Trypanosoma cruzi parasites. Front Cell Infect Microbiol. 2025; 15:1595333.

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Rodriguez F, Iniguez E, Pena Contreras G, Ahmed H, Costa TEMM, Skouta R, Maldonado RA. Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major. Molecules. 2018 07 04; 23(7).

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Subramaniam KS, Austin V, Schocker NS, Montoya AL, Anderson MS, Ashmus RA, Mesri M, Al-Salem W, Almeida IC, Michael K, Acosta-Serrano A. Anti-a-Gal antibodies detected by novel neoglycoproteins as a diagnostic tool for Old World cutaneous leishmaniasis caused by Leishmania major. Parasitology. 2018 11; 145(13):1758-1764.

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Iniguez E, Schocker NS, Subramaniam K, Portillo S, Montoya AL, Al-Salem WS, Torres CL, Rodriguez F, Moreira OC, Acosta-Serrano A, Michael K, Almeida IC, Maldonado RA. An a-Gal-containing neoglycoprotein-based vaccine partially protects against murine cutaneous leishmaniasis caused by Leishmania major. PLoS Negl Trop Dis. 2017 Oct; 11(10):e0006039.

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Iniguez E, Varela-Ramirez A, Mart?nez A, Torres CL, S?nchez-Delgado RA, Maldonado RA. Ruthenium-Clotrimazole complex has significant efficacy in the murine model of cutaneous leishmaniasis. Acta Trop. 2016 Dec; 164:402-410.

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Iniguez EA, Perez A, Maldonado RA, Skouta R. Novel arylalkylamine compounds exhibits potent selective antiparasitic activity against Leishmania major. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5315-20.

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Vasquez MA, Iniguez E, Das U, Beverley SM, Herrera LJ, Dimmock JR, Maldonado RA. Evaluation of a,?-unsaturated ketones as antileishmanial agents. Antimicrob Agents Chemother. 2015; 59(6):3598-601.

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Al-Salem WS, Ferreira DM, Dyer NA, Alyamani EJ, Balghonaim SM, Al-Mehna AY, Al-Zubiany S, Ibrahim el-K, Al Shahrani AM, Alkhuailed H, Aldahan MA, Al Jarallh AM, Abdelhady SS, Al-Zahrani MH, Almeida IC, Acosta-Serrano A. Detection of high levels of anti-a-galactosyl antibodies in sera of patients with Old World cutaneous leishmaniasis: a possible tool for diagnosis and biomarker for cure in an elimination setting. Parasitology. 2014 Dec; 141(14):1898-903.

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Ogungbe IV, Ng JD, Setzer WN. Interactions of antiparasitic alkaloids with Leishmania protein targets: a molecular docking analysis. Future Med Chem. 2013 Oct; 5(15):1777-99.

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Iniguez E, S?nchez A, Vasquez MA, Mart?nez A, Olivas J, Sattler A, S?nchez-Delgado RA, Maldonado RA. Metal-drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells. J Biol Inorg Chem. 2013 Oct; 18(7):779-90.

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