beta-N-Acetylhexosaminidases
"beta-N-Acetylhexosaminidases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A hexosaminidase specific for non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. It acts on GLUCOSIDES; GALACTOSIDES; and several OLIGOSACCHARIDES. Two specific mammalian isoenzymes of beta-N-acetylhexoaminidase are referred to as HEXOSAMINIDASE A and HEXOSAMINIDASE B. Deficiency of the type A isoenzyme causes TAY-SACHS DISEASE, while deficiency of both A and B isozymes causes SANDHOFF DISEASE. The enzyme has also been used as a tumor marker to distinguish between malignant and benign disease.
| Descriptor ID |
D001619
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| MeSH Number(s) |
D08.811.277.450.483.180
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| Concept/Terms |
beta-N-Acetylhexosaminidases- beta-N-Acetylhexosaminidases
- beta N Acetylhexosaminidases
- N-Acetyl-beta-D-hexosaminidase
- N Acetyl beta D hexosaminidase
- beta-N-Acetyl-hexosaminidase
- beta N Acetyl hexosaminidase
- beta-N-Acetylhexosaminidase
- beta N Acetylhexosaminidase
- beta-Hexosaminidase
- beta Hexosaminidase
- beta-N-Acetyl-D-hexosaminidase
- beta N Acetyl D hexosaminidase
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Below are MeSH descriptors whose meaning is more general than "beta-N-Acetylhexosaminidases".
Below are MeSH descriptors whose meaning is more specific than "beta-N-Acetylhexosaminidases".
This graph shows the total number of publications written about "beta-N-Acetylhexosaminidases" by people in this website by year, and whether "beta-N-Acetylhexosaminidases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 1 | 0 | 1 |
| 2007 | 1 | 0 | 1 |
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Below are the most recent publications written about "beta-N-Acetylhexosaminidases" by people in Profiles.
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Cameron EA, Martinez-Marignac VL, Chan A, Valladares A, Simmonds LV, Wacher N, Kumate J, McKeigue P, Shriver MD, Kittles R, Cruz M, Parra EJ. MGEA5-14 polymorphism and type 2 diabetes in Mexico City. Am J Hum Biol. 2007 Jul-Aug; 19(4):593-6.
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Kleiman FE, Ram?rez AO, Dodelson de Kremer R, Gravel RA, Argara?a CE. A frequent TG deletion near the polyadenylation signal of the human HEXB gene: occurrence of an irregular DNA structure and conserved nucleotide sequence motif in the 3' untranslated region. Hum Mutat. 1998; 12(5):320-9.
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Kleiman FE, de Kremer RD, de Ramirez AO, Gravel RA, Argara?a CE. Sandhoff disease in Argentina: high frequency of a splice site mutation in the HEXB gene and correlation between enzyme and DNA-based tests for heterozygote detection. Hum Genet. 1994 Sep; 94(3):279-82.
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Vaughan MK, Chambers JP, Tsin AT, Vaughan GM, Reiter RJ. Pineal and retinal lysosomal enzyme rhythms. Brain Res. 1987 Aug 11; 417(2):321-6.