Cleavage Stimulation Factor
"Cleavage Stimulation Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A RNA-binding protein that stimulates the cleavage of the 3' end of MRNA near the POLYADENYLATION site. It is a heterotrimer of 55-, 64- and 77-kDa subunits and combines with CLEAVAGE STIMULATION FACTOR to form a stable complex with mRNA that directs the 3' cleavage and polyadenylation reaction.
| Descriptor ID |
D039241
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| MeSH Number(s) |
D12.776.157.725.124.249 D12.776.664.962.444.249
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Cleavage Stimulation Factor".
Below are MeSH descriptors whose meaning is more specific than "Cleavage Stimulation Factor".
This graph shows the total number of publications written about "Cleavage Stimulation Factor" by people in this website by year, and whether "Cleavage Stimulation Factor" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 2 | 0 | 2 |
| 2011 | 1 | 0 | 1 |
| 2018 | 1 | 0 | 1 |
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Below are the most recent publications written about "Cleavage Stimulation Factor" by people in Profiles.
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Fonseca D, Baquero J, Murphy MR, Aruggoda G, Varriano S, Sapienza C, Mashadova O, Rahman S, Kleiman FE. mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response. Mol Cell Biol. 2018 02 15; 38(4).
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Nazeer FI, Devany E, Mohammed S, Fonseca D, Akukwe B, Taveras C, Kleiman FE. p53 inhibits mRNA 3' processing through its interaction with the CstF/BARD1 complex. Oncogene. 2011 Jul 07; 30(27):3073-83.
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Edwards RA, Lee MS, Tsutakawa SE, Williams RS, Nazeer I, Kleiman FE, Tainer JA, Glover JN. The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50. Biochemistry. 2008 Nov 04; 47(44):11446-56.
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Mirkin N, Fonseca D, Mohammed S, Cevher MA, Manley JL, Kleiman FE. The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Res. 2008 Apr; 36(6):1792-804.