Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.

Li L, Aggarwal BB, Shishodia S, Abbruzzese J, Kurzrock R. Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. Cancer. 2004 Nov 15; 101(10):2351-62.

View in: PubMed

subject areas

Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Cell Proliferation
Curcumin
Down-Regulation
Electrophoretic Mobility Shift Assay
Enzyme-Linked Immunosorbent Assay
Humans
I-kappa B Kinase
Immunoblotting
Interleukin-8
NF-kappa B
Pancreatic Neoplasms

authors with profiles

Shishir Shishodia

RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

For technical support please contact support