TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC. TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection. PLoS Pathog. 2016 Jan; 12(1):e1005349.

View in: PubMed

subject areas

Animals
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Separation
Disease Progression
DNA, Viral
Flow Cytometry
HIV Infections
Humans
Lymphocyte Activation
Macaca mulatta
Receptors, Immunologic
RNA, Viral
Simian Acquired Immunodeficiency Syndrome

authors with profiles

Brooks Mitchell, PhD
Tsuyoshi Fujita, MD PhD
Cecilia M. Shikuma,MD
Lishomwa Ndhlovu, MD PhD

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