Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity.

Santiago-Vazquez Y, Das S, Das U, Robles-Escajeda E, Ortega NM, Lema C, Varela-Ram?rez A, Aguilera RJ, Balzarini J, De Clercq E, Dimmock SG, Gorecki DK, Dimmock JR. Novel 3,5-bis(arylidene)-4-oxo-1-piperidinyl dimers: structure-activity relationships and potent antileukemic and antilymphoma cytotoxicity. Eur J Med Chem. 2014 Apr 22; 77:315-22.

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subject areas

Antineoplastic Agents
Apoptosis
Cell Line, Tumor
Cell Proliferation
Dimerization
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Hela Cells
HL-60 Cells
Humans
Leukemia
Lymphoma
Molecular Structure
Piperidines
Structure-Activity Relationship

authors with profiles

Renato J. Aguilera

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