Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients.

Chen Y, Li Y, Qi C, Zhang C, Liu D, Deng Y, Fu Y, Khadka VS, Wang DD, Tan S, Liu S, Peng Z, Gong J, Lin PP, Zhang X, Li J, Li Y, Shen L. Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients. Cancer Lett. 2021 10 01; 517:78-87.

View in: PubMed

subject areas

Aneuploidy
Chromatin
Chromatin Assembly and Disassembly
Chromosomes, Human, Pair 8
Drug Resistance, Neoplasm
Female
Genomics
Humans
Male
Middle Aged
Mutation
Neoplastic Cells, Circulating
Proto-Oncogene Proteins p21(ras)
Signal Transduction
Stomach Neoplasms
Trisomy

authors with profiles

Vedbar Khdka, PhD

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