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Vedbar Khdka, PhD

Title
Faculty RankAssistant Professor
InstitutionUniversity of Hawaii
DepartmentQuantitative Health Sciences
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
Phone8086921462
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Miller C, Morikawa K, Benny P, Riel J, Fialkowski MK, Qin Y, Khadka V, Lee MJ. Effects of Dietary Quality on Vaginal Microbiome Composition Throughout Pregnancy in a Multi-Ethnic Cohort. Nutrients. 2024 Oct 08; 16(19). PMID: 39408372.
      Citations:    Fields:    Translation:HumansCells
    2. Miller C, Luu K, Mikami B, Riel J, Qin Y, Khadka V, Lee MJ. Temporal Investigation of the Maternal Origins of Fetal Gut Microbiota. Microorganisms. 2024 Sep 09; 12(9). PMID: 39338539.
      Citations:    
    3. Kuehu DL, Fu Y, Nasu M, Yang H, Khadka VS, Deng Y. Effects of Heat-Induced Oxidative Stress and Astaxanthin on the NF-kB, NFE2L2 and PPARa Transcription Factors and Cytoprotective Capacity in the Thymus of Broilers. Curr Issues Mol Biol. 2024 Aug 22; 46(8):9215-9233. PMID: 39194761.
      Citations:    Fields:    
    4. Kuehu DL, Fu Y, Nasu M, Yang H, Khadka VS, Deng Y. Use of Microalgae-Derived Astaxanthin to Improve Cytoprotective Capacity in the Ileum of Heat-Induced Oxidative Stressed Broilers. Animals (Basel). 2024 Jun 29; 14(13). PMID: 38998041.
      Citations:    
    5. Yoon H, Dean LS, Jiyarom B, Khadka VS, Deng Y, Nerurkar VR, Chow DC, Shikuma CM, Devendra G, Koh Y, Park J. Single-cell RNA sequencing reveals characteristics of myeloid cells in post-acute sequelae of SARS-CoV-2 patients with persistent respiratory symptoms. Front Immunol. 2023; 14:1268510. PMID: 38259488.
      Citations: 2     Fields:    Translation:HumansCells
    6. Nasu M, Khadka VS, Jijiwa M, Kobayashi K, Deng Y. Exploring Optimal Biomarker Sources: A Comparative Analysis of Exosomes and Whole Plasma in Fasting and Non-Fasting Conditions for Liquid Biopsy Applications. Int J Mol Sci. 2023 Dec 27; 25(1). PMID: 38203541.
      Citations: 2     Fields:    Translation:HumansCells
    7. Nakatsu K, Jijiwa M, Khadka V, Nasu M, Deng Y. sRNAfrag: a pipeline and suite of tools to analyze fragmentation in small RNA sequencing data. Brief Bioinform. 2023 11 22; 25(1). PMID: 38243693.
      Citations:    Fields:    
    8. Nakatsu K, Jijiwa M, Khadka V, Nasu M, Huo M, Deng Y. sRNAfrag: A pipeline and suite of tools to analyze fragmentation in small RNA sequencing data. bioRxiv. 2023 Aug 21. PMID: 37662282.
      Citations:    
    9. Yoon H, Dean LS, Jiyarom B, Khadka V, Deng Y, Nerurukar VR, Chow DC, Shikuma CM, Devendra G, Koh Y, Park J. Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2. bioRxiv. 2023 Aug 02. PMID: 37577518.
      Citations:    
    10. Khadka VS, Nasu M, Deng Y, Jijiwa M. Circulating microRNA Biomarker for Detecting Breast Cancer in High-Risk Benign Breast Tumors. Int J Mol Sci. 2023 Apr 20; 24(8). PMID: 37108716.
      Citations: 5     Fields:    Translation:Humans
    11. Yang WS, Caliva MJ, Khadka VS, Tiirikainen M, Matter ML, Deng Y, Ramos JW. RSK1 and RSK2 serine/threonine kinases regulate different transcription programs in cancer. Front Cell Dev Biol. 2022; 10:1015665. PMID: 36684450.
      Citations:    
    12. Adhikari B, Lee CN, Khadka VS, Deng Y, Fukumoto G, Thorne M, Caires K, Odani J, Mishra B. RNA-Sequencing based analysis of bovine endometrium during the maternal recognition of pregnancy. BMC Genomics. 2022 Jul 07; 23(1):494. PMID: 35799127.
      Citations: 6     Fields:    Translation:Animals
    13. Urena F, Ma C, Hoffmann FW, Nunes LGA, Urschitz J, Moisyadi S, Khadka VS, Deng Y, Hoffmann PR. T-cell activation decreases miRNA-15a/16 levels to promote MEK1-ERK1/2-Elk1 signaling and proliferative capacity. J Biol Chem. 2022 03; 298(3):101634. PMID: 35085550.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Bartlett B, Gao Z, Schukking M, Menor M, Khadka VS, Fabbri M, Fei P, Deng Y. The miRNA Profile of Inflammatory Colorectal Tumors Identify TGF-? as a Companion Target for Checkpoint Blockade Immunotherapy. Front Cell Dev Biol. 2021; 9:754507. PMID: 34722540.
      Citations:    
    15. Rodriguez RM, Menor M, Hernandez BY, Deng Y, Khadka VS. Bacterial Diversity Correlates with Overall Survival in Cancers of the Head and Neck, Liver, and Stomach. Molecules. 2021 Sep 17; 26(18). PMID: 34577130.
      Citations: 5     Fields:    Translation:HumansCells
    16. Miller CB, Benny P, Riel J, Boushey C, Perez R, Khadka V, Qin Y, Maunakea AK, Lee MJ. Adherence to Mediterranean diet impacts gastrointestinal microbial diversity throughout pregnancy. BMC Pregnancy Childbirth. 2021 Aug 16; 21(1):558. PMID: 34399704.
      Citations: 15     Fields:    Translation:Humans
    17. Williams AL, Walton CB, Pinell B, Khadka VS, Dunn B, Lee K, Anagaran MCT, Avelar A, Shohet RV. Ischemic heart injury leads to HIF1-dependent differential splicing of CaMK2?. Sci Rep. 2021 06 23; 11(1):13116. PMID: 34162925.
      Citations: 10     Fields:    Translation:AnimalsCells
    18. Chen Y, Li Y, Qi C, Zhang C, Liu D, Deng Y, Fu Y, Khadka VS, Wang DD, Tan S, Liu S, Peng Z, Gong J, Lin PP, Zhang X, Li J, Li Y, Shen L. Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients. Cancer Lett. 2021 10 01; 517:78-87. PMID: 34126192.
      Citations: 12     Fields:    Translation:HumansCells
    19. Sah N, Kuehu DL, Khadka VS, Deng Y, Jha R, Wasti S, Mishra B. RNA sequencing-based analysis of the magnum tissues revealed the novel genes and biological pathways involved in the egg-white formation in the laying hen. BMC Genomics. 2021 May 01; 22(1):318. PMID: 33932994.
      Citations: 5     Fields:    Translation:HumansAnimals
    20. Ma C, Hoffmann FW, Marciel MP, Page KE, Williams-Aduja MA, Akana ENL, Gojanovich GS, Gerschenson M, Urschitz J, Moisyadi S, Khadka VS, Rozovsky S, Deng Y, Horgen FD, Hoffmann PR. Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metab. 2021 05; 47:101170. PMID: 33484950.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Seale LA, Ogawa-Wong AN, Watanabe LM, Khadka VS, Menor M, Torres DJ, Carlson BA, Hatfield DL, Berry MJ. Adaptive Thermogenesis in a Mouse Model Lacking Selenoprotein Biosynthesis in Brown Adipocytes. Int J Mol Sci. 2021 Jan 09; 22(2). PMID: 33435397.
      Citations: 5     Fields:    Translation:AnimalsCells
    22. Rodriguez RM, Khadka VS, Menor M, Hernandez BY, Deng Y. Tissue-associated microbial detection in cancer using human sequencing data. BMC Bioinformatics. 2020 Dec 03; 21(Suppl 9):523. PMID: 33272199.
      Citations: 7     Fields:    Translation:Humans
    23. SahBandar IN, Chew GM, Corley MJ, Pang APS, Tsai N, Hanks N, Khadka VS, Klatt NR, Hensley-McBain T, Somsouk M, Vujkovic-Cvijin I, Chow DC, Shikuma CM, Ndhlovu LC. Changes in gastrointestinal microbial communities influence HIV-specific CD8+ T-cell responsiveness to immune checkpoint blockade. AIDS. 2020 08 01; 34(10):1451-1460. PMID: 32675558.
      Citations: 3     Fields:    Translation:HumansCells
    24. Williams AL, Khadka VS, Anagaran MCT, Lee K, Avelar A, Deng Y, Shohet RV. miR-125 family regulates XIRP1 and FIH in response to myocardial infarction. Physiol Genomics. 2020 08 01; 52(8):358-368. PMID: 32716698.
      Citations: 2     Fields:    Translation:AnimalsCells
    25. Zhao T, Khadka VS, Deng Y. Identification of lncRNA biomarkers for lung cancer through integrative cross-platform data analyses. Aging (Albany NY). 2020 07 16; 12(14):14506-14527. PMID: 32675385.
      Citations: 13     Fields:    Translation:Humans
    26. Rodriguez RM, Hernandez BY, Menor M, Deng Y, Khadka VS. The landscape of bacterial presence in tumor and adjacent normal tissue across 9 major cancer types using TCGA exome sequencing. Comput Struct Biotechnol J. 2020; 18:631-641. PMID: 32257046.
      Citations:    
    27. Itami Y, Miyake M, Ohnishi S, Tatsumi Y, Gotoh D, Hori S, Morizawa Y, Iida K, Ohnishi K, Nakai Y, Inoue T, Anai S, Tanaka N, Fujii T, Shimada K, Furuya H, Khadka VS, Deng Y, Fujimoto K. Disabled Homolog 2 (DAB2) Protein in Tumor Microenvironment Correlates with Aggressive Phenotype in Human Urothelial Carcinoma of the Bladder. Diagnostics (Basel). 2020 Jan 20; 10(1). PMID: 31968685.
      Citations:    
    28. D'Antoni ML, Kallianpur KJ, Premeaux TA, Corley MJ, Fujita T, Laws EI, Ogata-Arakaki D, Chow DC, Khadka VS, Shikuma CM, Ndhlovu LC. Lower Interferon Regulatory Factor-8 Expression in Peripheral Myeloid Cells Tracks With Adverse Central Nervous System Outcomes in Treated HIV Infection. Front Immunol. 2019; 10:2789. PMID: 31849969.
      Citations: 1     Fields:    Translation:HumansCells
    29. Seale LA, Khadka VS, Menor M, Xie G, Watanabe LM, Sasuclark A, Guirguis K, Ha HY, Hashimoto AC, Peplowska K, Tiirikainen M, Jia W, Berry MJ, Deng Y. Combined Omics Reveals That Disruption of the Selenocysteine Lyase Gene Affects Amino Acid Pathways in Mice. Nutrients. 2019 Oct 26; 11(11). PMID: 31717805.
      Citations: 4     Fields:    Translation:AnimalsCells
    30. Corley MJ, Vargas-Maya N, Pang APS, Lum-Jones A, Li D, Khadka V, Sultana R, Blanchard DC, Maunakea AK. Epigenetic Delay in the Neurodevelopmental Trajectory of DNA Methylation States in Autism Spectrum Disorders. Front Genet. 2019; 10:907. PMID: 31681403.
      Citations:    
    31. Hoffmann PR, Hoffmann FW, Premeaux TA, Fujita T, Soprana E, Panigada M, Chew GM, Richard G, Hindocha P, Menor M, Khadka VS, Deng Y, Moise L, Ndhlovu LC, Siccardi A, Weinberg AD, De Groot AS, Bertino P. Multi-antigen Vaccination With Simultaneous Engagement of the OX40 Receptor Delays Malignant Mesothelioma Growth and Increases Survival in Animal Models. Front Oncol. 2019; 9:720. PMID: 31428586.
      Citations:    
    32. Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults. Clin Epigenetics. 2019 06 28; 11(1):95. PMID: 31253200.
      Citations: 9     Fields:    Translation:HumansCells
    33. Sasuclark AR, Khadka VS, Pitts MW. Cell-Type Specific Analysis of Selenium-Related Genes in Brain. Antioxidants (Basel). 2019 May 05; 8(5). PMID: 31060314.
      Citations:    
    34. Deng Y, Zhu Y, Wang H, Khadka VS, Hu L, Ai J, Dou Y, Li Y, Dai S, Mason CE, Wang Y, Jia W, Zhang J, Huang G, Jiang B. Ratio-Based Method To Identify True Biomarkers by Normalizing Circulating ncRNA Sequencing and Quantitative PCR Data. Anal Chem. 2019 05 21; 91(10):6746-6753. PMID: 31002238.
      Citations: 16     Fields:    Translation:HumansAnimals
    35. Gong T, Hashimoto AC, Sasuclark AR, Khadka VS, Gurary A, Pitts MW. Selenoprotein M Promotes Hypothalamic Leptin Signaling and Thioredoxin Antioxidant Activity. Antioxid Redox Signal. 2021 10 01; 35(10):775-787. PMID: 30648404.
      Citations: 23     Fields:    Translation:AnimalsCells
    36. Khadka VS, Vaughn K, Xie J, Swaminathan P, Ma Q, Cramer GR, Fennell AY. Transcriptomic response is more sensitive to water deficit in shoots than roots of Vitis riparia (Michx.). BMC Plant Biol. 2019 Feb 13; 19(1):72. PMID: 30760212.
      Citations: 13     Fields:    Translation:AnimalsCells
    37. Fang R, Zhu Y, Hu L, Khadka VS, Ai J, Zou H, Ju D, Jiang B, Deng Y, Hu X. Plasma MicroRNA Pair Panels as Novel Biomarkers for Detection of Early Stage Breast Cancer. Front Physiol. 2018; 9:1879. PMID: 30670982.
      Citations:    
    38. Siriwardhana C, Khadka VS, Chen JJ, Deng Y. Development of a miRNA-seq based prognostic signature in lung adenocarcinoma. BMC Cancer. 2019 Jan 08; 19(1):34. PMID: 30621620.
      Citations: 20     Fields:    Translation:HumansCells
    39. Fang R, Zhu Y, Khadka VS, Zhang F, Jiang B, Deng Y. The Evaluation of Serum Biomarkers for Non-small Cell Lung Cancer (NSCLC) Diagnosis. Front Physiol. 2018; 9:1710. PMID: 30555348.
      Citations:    
    40. Sah N, Kuehu DL, Khadka VS, Deng Y, Peplowska K, Jha R, Mishra B. RNA sequencing-based analysis of the laying hen uterus revealed the novel genes and biological pathways involved in the eggshell biomineralization. Sci Rep. 2018 11 15; 8(1):16853. PMID: 30443032.
      Citations: 25     Fields:    Translation:AnimalsCells
    41. D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC. Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities. J Infect Dis. 2018 09 22; 218(9):1453-1463. PMID: 29868826.
      Citations: 20     Fields:    Translation:HumansCTClinical Trials
    42. Balaan C, Corley MJ, Eulalio T, Leite-Ahyo K, Pang APS, Fang R, Khadka VS, Maunakea AK, Ward MA. Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder. Behav Brain Res. 2019 01 01; 356:137-147. PMID: 30134148.
      Citations: 10     Fields:    Translation:Animals
    43. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Correction: Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 07 20; 9(56):30937. PMID: 30112120.
      Citations: 1     Fields:    
    44. Williams AL, Khadka V, Tang M, Avelar A, Schunke KJ, Menor M, Shohet RV. HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction. Physiol Genomics. 2018 07 01; 50(7):479-494. PMID: 29652636.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    45. Marciel MP, Khadka VS, Deng Y, Kilicaslan P, Pham A, Bertino P, Lee K, Chen S, Glibetic N, Hoffmann FW, Matter ML, Hoffmann PR. Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis. Oncotarget. 2018 03 02; 9(17):13407-13422. PMID: 29568366.
      Citations: 16     Fields:    
    46. Miyake M, Hori S, Morizawa Y, Tatsumi Y, Toritsuka M, Ohnishi S, Shimada K, Furuya H, Khadka VS, Deng Y, Ohnishi K, Iida K, Gotoh D, Nakai Y, Inoue T, Anai S, Torimoto K, Aoki K, Tanaka N, Konishi N, Fujimoto K. Collagen type IV alpha 1 (COL4A1) and collagen type XIII alpha 1 (COL13A1) produced in cancer cells promote tumor budding at the invasion front in human urothelial carcinoma of the bladder. Oncotarget. 2017 May 30; 8(22):36099-36114. PMID: 28415608.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    47. Taylor DW, Bobbili N, Khadka VS, Quakyi IA, Leke RG. Individuals living in a malaria-endemic area of Cameroon do not have an acquired antibody response to Plasmodium falciparum histidine-rich protein 2. Malar J. 2017 02 01; 16(1):58. PMID: 28148260.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    48. Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 05 01; 9(5):585-96. PMID: 26989192.
      Citations: 9     Fields:    Translation:AnimalsCells
    49. Fennell AY, Schlauch KA, Gouthu S, Deluc LG, Khadka V, Sreekantan L, Grimplet J, Cramer GR, Mathiason KL. Short day transcriptomic programming during induction of dormancy in grapevine. Front Plant Sci. 2015; 6:834. PMID: 26582400.
      Citations:    
    50. Hu Z, Khadka VS, Wang W, Galipeau DW, Yan X. Theoretical study of two-photon absorption properties and up-conversion efficiency of new symmetric organic p-conjugated molecules for photovoltaic devices. J Mol Model. 2012 Aug; 18(8):3657-67. PMID: 22358392.
      Citations: 2     Fields:    Translation:Cells
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