A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease.
Killebrew JR, Perdue N, Kwan A, Thornton AM, Shevach EM, Campbell DJ. A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. J Immunol. 2011 Jul 15; 187(2):861-9.
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Animals
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Autoantigens
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Autoimmune Diseases
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Cell Differentiation
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Cells, Cultured
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Coculture Techniques
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Epitopes, T-Lymphocyte
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Forkhead Transcription Factors
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Immune Tolerance
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Lymphocyte Activation
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Lymphopenia
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Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
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Receptors, Antigen, T-Cell, alpha-beta
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Skin
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Thymus Gland
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T-Lymphocytes, Regulatory
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Transcription, Genetic