Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors.

Brotherton-Pleiss C, Yue P, Zhu Y, Nakamura K, Chen W, Fu W, Kubota C, Chen J, Alonso-Valenteen F, Mikhael S, Medina-Kauwe L, Tius MA, Lopez-Tapia F, Turkson J. Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. J Med Chem. 2021 01 14; 64(1):695-710.

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subject areas

Amides
Apoptosis
Azetidines
Cell Line, Tumor
Cell Survival
DNA
Drug Evaluation, Preclinical
Humans
Inhibitory Concentration 50
Phosphorylation
Protein Binding
STAT3 Transcription Factor
Structure-Activity Relationship

authors with profiles

Marcus Tius, PhD

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