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Christopher C. Williams

TitleBynum and Sons,Inc Endowed Professor Chair, Division of Basic Pharmaceutical Sciences
Faculty RankAssociate Professor
InstitutionXavier University of Louisiana
DepartmentDBPS
AddressXavier University of Louisiana
1 Drexel Drive
DBPS
New Orleans LA 70125
Phone5045207435
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    Dr. Williams earned a Bachelor of Science degree in Biology from Southern University at New Orleans. As a graduate student at Tulane University in the department of pharmacology, Dr. Williams’ studies focused on the role of HIV Tat protein in mediating hematopoietic dysfunction of HIV infection. After matriculation in 2003, Dr. Williams began postdoctoral training in the Tulane University Cancer Center where his research focused on the novel role of the ERB4 tyrosine receptor kinase as a molecular chaperone and transcriptional co-activator for Stat5a and estrogen receptor in breast cancer. Later his studies centered on the identification and characterization of novel phosphorylation sites in estrogen receptor a, and how they correlate to disease progression and sensitivity to hormonal therapies.
    Dr. Williams joined Xavier University College of Pharmacy in 2009, where he currently serves as assistant professor of pharmacology. Dr. Williams' laboratory focuses on the roles of the NR4A family of orphan nuclear receptor in breast cancer etiology and sensitivity to antineoplastic/chemopreventive drugs. Additionally, the lab is currently investigating the molecular mechanisms underlying metformin’s antineoplastic effects in breast cancer.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tilghman SL, Townley I, Zhong Q, Carriere PP, Zou J, Llopis SD, Preyan LC, Williams CC, Skripnikova E, Bratton MR, Zhang Q, Wang G. Proteomic signatures of acquired letrozole resistance in breast cancer: suppressed estrogen signaling and increased cell motility and invasiveness. Mol Cell Proteomics. 2013 Sep; 12(9):2440-55. PMID: 23704778.
      Citations: 28     Fields:    Translation:HumansCells
    2. Llopis S, Singleton B, Duplessis T, Carrier L, Rowan B, Williams C. Dichotomous roles for the orphan nuclear receptor NURR1 in breast cancer. BMC Cancer. 2013 Mar 21; 13:139. PMID: 23517088.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    3. Williams CC, Singleton BA, Llopis SD, Skripnikova EV. Metformin induces a senescence-associated gene signature in breast cancer cells. J Health Care Poor Underserved. 2013 Feb; 24(1 Suppl):93-103. PMID: 23395946.
      Citations: 4     Fields:    Translation:Humans
    4. Huderson BP, Duplessis TT, Williams CC, Seger HC, Marsden CG, Pouey KJ, Hill SM, Rowan BG. Stable inhibition of specific estrogen receptor a (ERa) phosphorylation confers increased growth, migration/invasion, and disruption of estradiol signaling in MCF-7 breast cancer cells. Endocrinology. 2012 Sep; 153(9):4144-59. PMID: 22733972.
      Citations: 10     Fields:    Translation:HumansCells
    5. Duplessis TT, Williams CC, Hill SM, Rowan BG. Phosphorylation of Estrogen Receptor a at serine 118 directs recruitment of promoter complexes and gene-specific transcription. Endocrinology. 2011 Jun; 152(6):2517-26. PMID: 21505052.
      Citations: 25     Fields:    Translation:HumansCells
    6. Heard M, Maina CV, Morehead BE, Hoener MC, Nguyen TQ, Williams CC, Rowan BG, Gissendanner CR. A functional NR4A nuclear receptor DNA-binding domain is required for organ development in Caenorhabditis elegans. Genesis. 2010 Aug; 48(8):485-91. PMID: 20506374.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    7. Williams CC, Basu A, El-Gharbawy A, Carrier LM, Smith CL, Rowan BG. Identification of four novel phosphorylation sites in estrogen receptor alpha: impact on receptor-dependent gene expression and phosphorylation by protein kinase CK2. BMC Biochem. 2009 Dec 31; 10:36. PMID: 20043841.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    8. Murphy LC, Skliris GP, Rowan BG, Al-Dhaheri M, Williams C, Penner C, Troup S, Begic S, Parisien M, Watson PH. The relevance of phosphorylated forms of estrogen receptor in human breast cancer in vivo. J Steroid Biochem Mol Biol. 2009 Mar; 114(1-2):90-5. PMID: 19429437.
      Citations: 11     Fields:    Translation:HumansCells
    9. Skliris GP, Rowan BG, Al-Dhaheri M, Williams C, Troup S, Begic S, Parisien M, Watson PH, Murphy LC. Immunohistochemical validation of multiple phospho-specific epitopes for estrogen receptor alpha (ERalpha) in tissue microarrays of ERalpha positive human breast carcinomas. Breast Cancer Res Treat. 2009 Dec; 118(3):443-53. PMID: 19104930.
      Citations: 20     Fields:    Translation:HumansCells
    10. Zhu Y, Sullivan LL, Nair SS, Williams CC, Pandey AK, Marrero L, Vadlamudi RK, Jones FE. Coregulation of estrogen receptor by ERBB4/HER4 establishes a growth-promoting autocrine signal in breast tumor cells. Cancer Res. 2006 Aug 15; 66(16):7991-8. PMID: 16912174.
      Citations: 58     Fields:    Translation:HumansCells
    11. Williams CA, Mondal D, Agrawal KC. The HIV-1 Tat protein enhances megakaryocytic commitment of K562 cells by facilitating CREB transcription factor coactivation by CBP. Exp Biol Med (Maywood). 2005 Dec; 230(11):872-84. PMID: 16339753.
      Citations: 3     Fields:    Translation:HumansCells
    12. Mondal D, Williams CA, Ali M, Eilers M, Agrawal KC. The HIV-1 Tat protein selectively enhances CXCR4 and inhibits CCR5 expression in megakaryocytic K562 cells. Exp Biol Med (Maywood). 2005 Oct; 230(9):631-44. PMID: 16179731.
      Citations: 6     Fields:    Translation:HumansCells
    13. Clark DE, Williams CC, Duplessis TT, Moring KL, Notwick AR, Long W, Lane WS, Beuvink I, Hynes NE, Jones FE. ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. J Biol Chem. 2005 Jun 24; 280(25):24175-80. PMID: 15863494.
      Citations: 21     Fields:    Translation:AnimalsCells
    14. Williams CC, Allison JG, Vidal GA, Burow ME, Beckman BS, Marrero L, Jones FE. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J Cell Biol. 2004 Nov 08; 167(3):469-78. PMID: 15534001.
      Citations: 109     Fields:    Translation:HumansCells
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