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Alika Maunakea, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry, and Physiology 
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Collapse Research 
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    F31NS049850     (MAUNAKEA, ALIKA K)Jun 3, 2005 - Jun 2, 2008
    NIH
    The Contribution of CpG Island Methylation to the Tissue-Specific Expression of S
    Role: Principal Investigator
    K01HL125504     (MAUNAKEA, ALIKA KEOLAOKALANI)Nov 15, 2014 - Oct 31, 2018
    NIH
    Identifying Epigenetic Biomarkers of Cardiovascular Disease Risk In Humans
    Role: Principal Investigator
    R21MH114005     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 1, 2017 - Aug 31, 2019
    NIH
    Epigenomic Dysregulation of Neurodevelopmental Genes Underlies Autism Spectrum Disorders
    Role: Principal Investigator
    R03HL146886     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 1, 2019 - Aug 31, 2021
    NIH
    Epigenomic Conditioning of Monocyte Inflammatory Activity in Native Hawaiians with Diabetes
    Role: Principal Investigator
    R56MD014630     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 26, 2019 - Aug 31, 2020
    NIH
    Immunoepigenetic-gut microbiome axis in the social networks of health disparate youth
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Vargas-Maya NI, Maunakea AK, Ram?rez-Montiel FB, Sultana R, Peres R, Mac?as-Cervantes QX, Medina-Nieto AL, Rangel-Serrano ?, Mart?nez-?lvarez JA, P?ramo-P?rez I, Anaya-Vel?zquez F, Padilla-Vaca F, Franco B. Avirulent UG10 Entamoeba histolytica mutant derived from HM-1:IMSS strain shows limited genome variability and aberrant 5-methyl cytosine genomic distribution. Mol Biochem Parasitol. 2024 Jul 11; 260:111647. PMID: 39002760.
      Citations:    Fields:    
    2. Maunakea AK, Phankitnirundorn K, Peres R, Dye C, Juarez R, Walsh C, Slavens C, Park SL, Wilkens LR, Le Marchand L. Socioeconomic Status, Lifestyle, and DNA Methylation Age Among Racially and Ethnically Diverse Adults: NIMHD Social Epigenomics Program. JAMA Netw Open. 2024 Jul 01; 7(7):e2421889. PMID: 39073814.
      Citations:    Fields:    Translation:HumansCells
    3. Umeda L, Torres A, Kunihiro BP, Rubas NC, Wells RK, Phankitnirundorn K, Peres R, Juarez R, Maunakea AK. Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2. Vaccines (Basel). 2024 Jun 07; 12(6). PMID: 38932366.
      Citations:    
    4. Allan NP, Yamamoto BY, Kunihiro BP, Nunokawa CKL, Rubas NC, Wells RK, Umeda L, Phankitnirundorn K, Torres A, Peres R, Takahashi E, Maunakea AK. Ketogenic Diet Induced Shifts in the Gut Microbiome Associate with Changes to Inflammatory Cytokines and Brain-Related miRNAs in Children with Autism Spectrum Disorder. Nutrients. 2024 May 07; 16(10). PMID: 38794639.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    5. Rubas NC, Peres R, Kunihiro BP, Allan NP, Phankitnirundorn K, Wells RK, McCracken T, Lee RH, Umeda L, Conching A, Juarez R, Maunakea AK. Author Correction: HMGB1 mediates microbiome-immune axis dysregulation underlying reduced neutralization capacity in obesity-related post-acute sequelae of SARS-CoV-2. Sci Rep. 2024 Mar 19; 14(1):6559. PMID: 38504105.
      Citations:    Fields:    
    6. Huang BZ, Binder AM, Quon B, Patel YM, Lum-Jones A, Tiirikainen M, Murphy SE, Loo L, Maunakea AK, Haiman CA, Wilkens LR, Koh WP, Cai Q, Aldrich MC, Siegmund KD, Hecht SS, Yuan JM, Blot WJ, Stram DO, Le Marchand L, Park SL. Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts. Am J Hum Genet. 2024 03 07; 111(3):456-472. PMID: 38367619.
      Citations: 1     Fields:    Translation:HumansCells
    7. Rubas NC, Peres R, Kunihiro BP, Allan NP, Phankitnirundorn K, Wells RK, McCracken T, Lee RH, Umeda L, Conching A, Juarez R, Maunakea AK. HMGB1 mediates microbiome-immune axis dysregulation underlying reduced neutralization capacity in obesity-related post-acute sequelae of SARS-CoV-2. Sci Rep. 2024 01 03; 14(1):355. PMID: 38172612.
      Citations: 1     Fields:    Translation:HumansCells
    8. Maunakea AK, Juarez R, Maunakea-Forth JK. The Mauli Ola Study: A Unique Academic-Community Partnership With MA'O Organic Farms to Understand and Address Health Inequities Among Native Hawaiians and Other Pacific Islanders in Hawai'i. Health Promot Pract. 2023 11; 24(6):1087-1090. PMID: 37877635.
      Citations: 1     Fields:    Translation:Humans
    9. Jernigan VBB, Demientieff LX, Maunakea AK. Food Sovereignty as a Path to Health Equity for Indigenous Communities: Introduction to the Focus Issue. Health Promot Pract. 2023 11; 24(6):1066-1069. PMID: 37877636.
      Citations:    Fields:    Translation:Humans
    10. Panova N, Allan NP, Rubas NC, Lee RH, Kunihiro BP, Umeda L, Peres R, Juarez R, Maunakea AK. Sequencing the SARS-CoV-2 Genome from Stool Samples of Post-acute Cases Implicates a Novel Mutation Associated with Reduced Antibody Neutralization. Eur J Biomed Res. 2023; 2(3):17-23. PMID: 37525697.
      Citations:    
    11. Becerra CY, Wells RK, Kunihiro BP, Lee RH, Umeda L, Allan NP, Rubas NC, McCracken TA, Nunokawa CKL, Lee MH, Pidlaoan FGS, Phankitnirondorn K, Dye CK, Yamamoto BY, Peres R, Juarez R, Maunakea AK. Examining the immunoepigenetic-gut microbiome axis in the context of self-esteem among Native Hawaiians and other Pacific Islanders. Front Genet. 2023; 14:1125217. PMID: 37152987.
      Citations:    
    12. Takahashi E, Allan N, Peres R, Ortug A, van der Kouwe AJW, Valli B, Ethier E, Levman J, Baumer N, Tsujimura K, Vargas-Maya NI, McCracken TA, Lee R, Maunakea AK. Integration of structural MRI and epigenetic analyses hint at linked cellular defects of the subventricular zone and insular cortex in autism: Findings from a case study. Front Neurosci. 2022; 16:1023665. PMID: 36817099.
      Citations:    
    13. Wells RK, Kunihiro BP, Phankitnirundorn K, Peres R, McCracken TA, Umeda L, Lee RH, Kim DY, Juarez R, Maunakea AK. Gut microbial indicators of metabolic health underlie age-related differences in obesity and diabetes risk among Native Hawaiians and Pacific Islanders. Front Cell Infect Microbiol. 2022; 12:1035641. PMID: 36619744.
      Citations: 2     Fields:    Translation:Humans
    14. Baumer Y, Farmer N, Maunakea AK, Needham BL, Powell-Wiley TM. Editorial: The biological impact of adversity on cardiovascular disease risk and obesity. Front Cardiovasc Med. 2022; 9:1022724. PMID: 36211565.
      Citations:    
    15. Juarez R, Phankitnirundorn K, Ramirez A, Peres R, Maunakea AK, Okihiro M. Vaccine-Associated Shifts in SARS-CoV-2 Infectivity Among the Native Hawaiian and Other Pacific Islander Population in Hawaii. Am J Public Health. 2022 11; 112(S9):S896-S899. PMID: 36108254.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    16. Juarez R, Kang Z, Okihiro M, Garcia BK, Phankitnirundorn K, Maunakea AK. Dynamics of Trust and Consumption of COVID-19 Information Implicate a Mechanism for COVID-19 Vaccine and Booster Uptake. Vaccines (Basel). 2022 Aug 31; 10(9). PMID: 36146513.
      Citations:    
    17. Dye CK, Corley MJ, Ing C, Lum-Jones A, Li D, Mau MKLM, Maunakea AK. Shifts in the immunoepigenomic landscape of monocytes in response to a diabetes-specific social support intervention: a pilot study among Native Hawaiian adults with diabetes. Clin Epigenetics. 2022 07 18; 14(1):91. PMID: 35851422.
      Citations: 3     Fields:    Translation:HumansCells
    18. Juarez R, Phankitnirundorn K, Okihiro M, Maunakea AK. Opposing Role of Trust as a Modifier of COVID-19 Vaccine Uptake in an Indigenous Population. Vaccines (Basel). 2022 Jun 17; 10(6). PMID: 35746577.
      Citations:    
    19. Juarez R, Siegal N, Maunakea AK. The Effects of COVID-19 Vaccine Mandates in Hawaii. Vaccines (Basel). 2022 May 13; 10(5). PMID: 35632529.
      Citations:    
    20. Shiohama T, Ortug A, Warren JLA, Valli B, Levman J, Faja SK, Tsujimura K, Maunakea AK, Takahashi E. Small Nucleus Accumbens and Large Cerebral Ventricles in Infants and Toddlers Prior to Receiving Diagnoses of Autism Spectrum Disorder. Cereb Cortex. 2022 03 04; 32(6):1200-1211. PMID: 34455432.
      Citations: 7     Fields:    Translation:Humans
    21. Andrasik MP, Maunakea AK, Oseso L, Rodriguez-Diaz CE, Wallace S, Walters K, Yukawa M. Awakening: The Unveiling of Historically Unaddressed Social Inequities During the COVID-19 Pandemic in the United States. Infect Dis Clin North Am. 2022 06; 36(2):295-308. PMID: 35636901.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    22. Miller CB, Benny P, Riel J, Boushey C, Perez R, Khadka V, Qin Y, Maunakea AK, Lee MJ. Adherence to Mediterranean diet impacts gastrointestinal microbial diversity throughout pregnancy. BMC Pregnancy Childbirth. 2021 Aug 16; 21(1):558. PMID: 34399704.
      Citations: 11     Fields:    Translation:Humans
    23. Rubas NC, Maunakea A. Medical School Hotline: Immunoepigenetic-Microbiome Axis: Implications for Health Disparities Research in Native Hawaiians and Pacific Islanders. Hawaii J Health Soc Welf. 2021 08; 80(8):195-198. PMID: 34355196.
      Citations: 2     Fields:    Translation:Humans
    24. Watanabe LM, Hashimoto AC, Torres DJ, Alfulaij N, Peres R, Sultana R, Maunakea AK, Berry MJ, Seale LA. Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase. Mol Cell Endocrinol. 2021 08 01; 533:111335. PMID: 34052303.
      Citations: 3     Fields:    Translation:Animals
    25. Go RCP, Corley MJ, Ross GW, Petrovitch H, Masaki KH, Maunakea AK, He Q, Tiirikainen MI. Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity. BMC Neurosci. 2020 07 10; 21(1):31. PMID: 32650713.
      Citations: 15     Fields:    Translation:HumansCells
    26. Corley MJ, Vargas-Maya N, Pang APS, Lum-Jones A, Li D, Khadka V, Sultana R, Blanchard DC, Maunakea AK. Epigenetic Delay in the Neurodevelopmental Trajectory of DNA Methylation States in Autism Spectrum Disorders. Front Genet. 2019; 10:907. PMID: 31681403.
      Citations:    
    27. Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults. Clin Epigenetics. 2019 06 28; 11(1):95. PMID: 31253200.
      Citations: 9     Fields:    Translation:HumansCells
    28. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. PMID: 30139389.
      Citations: 28     Fields:    Translation:HumansCells
    29. Balaan C, Corley MJ, Eulalio T, Leite-Ahyo K, Pang APS, Fang R, Khadka VS, Maunakea AK, Ward MA. Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder. Behav Brain Res. 2019 01 01; 356:137-147. PMID: 30134148.
      Citations: 9     Fields:    Translation:Animals
    30. Lee RWY, Corley MJ, Pang A, Arakaki G, Abbott L, Nishimoto M, Miyamoto R, Lee E, Yamamoto S, Maunakea AK, Lum-Jones A, Wong M. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018 05 01; 188:205-211. PMID: 29421589.
      Citations: 44     Fields:    Translation:Humans
    31. Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment. Sci Rep. 2016 09 15; 6:33310. PMID: 27629381.
      Citations: 28     Fields:    Translation:HumansCells
    32. Pang AP, Sugai C, Maunakea AK. High-throughput sequencing offers new insights into 5-hydroxymethylcytosine. Biomol Concepts. 2016 Jun 01; 7(3):169-78. PMID: 27356236.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    33. Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 05 01; 9(5):585-96. PMID: 26989192.
      Citations: 8     Fields:    Translation:AnimalsCells
    34. Kraushaar DC, Jin W, Maunakea A, Abraham B, Ha M, Zhao K. Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 2016 Feb 04; 17:21. PMID: 26846280.
      Citations: 1     Fields:    
    35. Townsend CK, Dillard A, Hosoda KK, Maskarinec GG, Maunakea AK, Yoshimura SR, Hughes C, Palakiko DM, Kehauoha BP, Kaholokula JK. Community-Based Participatory Research Integrates Behavioral and Biological Research to Achieve Health Equity for Native Hawaiians. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010004. PMID: 26703660.
      Citations: 12     Fields:    Translation:HumansPHPublic Health
    36. Corley MJ, Zhang W, Zheng X, Lum-Jones A, Maunakea AK. Semiconductor-based sequencing of genome-wide DNA methylation states. Epigenetics. 2015; 10(2):153-66. PMID: 25602802.
      Citations: 4     Fields:    Translation:HumansCells
    37. Maunakea AK, Chepelev I, Cui K, Zhao K. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013 Nov; 23(11):1256-69. PMID: 23938295.
      Citations: 283     Fields:    Translation:HumansCells
    38. Fu H, Maunakea AK, Martin MM, Huang L, Zhang Y, Ryan M, Kim R, Lin CM, Zhao K, Aladjem MI. Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet. 2013 Jun; 9(6):e1003542. PMID: 23754963.
      Citations: 56     Fields:    Translation:HumansCells
    39. Kraushaar DC, Jin W, Maunakea A, Abraham B, Ha M, Zhao K. Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 2013; 14(10):R121. PMID: 24176123.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    40. Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5626-31. PMID: 21427231.
      Citations: 54     Fields:    Translation:AnimalsCells
    41. Maunakea AK, Chepelev I, Zhao K. Epigenome mapping in normal and disease States. Circ Res. 2010 Aug 06; 107(3):327-39. PMID: 20689072.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    42. Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 2010 Jul 08; 466(7303):253-7. PMID: 20613842.
      Citations: 857     Fields:    Translation:HumansAnimalsCells
    43. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219.
      Citations: 462     Fields:    Translation:HumansAnimalsCells
    44. Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN. Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. Mol Cancer Ther. 2007 Feb; 6(2):391-403. PMID: 17272646.
      Citations: 27     Fields:    Translation:HumansCells
    45. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun; 37(6):645-51. PMID: 15895082.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    46. Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 01; 65(9):3617-23. PMID: 15867356.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    47. Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN. Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping. Cancer Res. 2003 Mar 01; 63(5):1000-11. PMID: 12615715.
      Citations: 19     Fields:    Translation:HumansCells
    48. Weinstein JN, Scherf U, Lee JK, Nishizuka S, Gwadry F, Bussey AK, Kim S, Smith LH, Tanabe L, Richman S, Alexander J, Kouros-Mehr H, Maunakea A, Reinhold WC. The bioinformatics of microarray gene expression profiling. Cytometry. 2002 Jan 01; 47(1):46-9. PMID: 11774349.
      Citations: 5     Fields:    Translation:Humans
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