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Alika Maunakea, PhD

Title
Faculty RankAssociate Professor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry, and Physiology 
AddressJohn A. Burns School of Medicine
University of Hawaii at Manoa
651 Ilalo Street
Honolulu HI 96813
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    Collapse Research 
    Collapse research activities and funding
    F31NS049850     (MAUNAKEA, ALIKA K)Jun 3, 2005 - Jun 2, 2008
    NIH
    The Contribution of CpG Island Methylation to the Tissue-Specific Expression of S
    Role: Principal Investigator

    K01HL125504     (MAUNAKEA, ALIKA KEOLAOKALANI)Nov 15, 2014 - Oct 31, 2018
    NIH
    Identifying Epigenetic Biomarkers of Cardiovascular Disease Risk In Humans
    Role: Principal Investigator

    R21MH114005     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 1, 2017 - Aug 31, 2019
    NIH
    Epigenomic Dysregulation of Neurodevelopmental Genes Underlies Autism Spectrum Disorders
    Role: Principal Investigator

    R03HL146886     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 1, 2019 - Aug 31, 2021
    NIH
    Epigenomic Conditioning of Monocyte Inflammatory Activity in Native Hawaiians with Diabetes
    Role: Principal Investigator

    R56MD014630     (MAUNAKEA, ALIKA KEOLAOKALANI)Sep 26, 2019 - Aug 31, 2020
    NIH
    Immunoepigenetic-gut microbiome axis in the social networks of health disparate youth
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rubas NC, Maunakea A. Medical School Hotline: Immunoepigenetic-Microbiome Axis: Implications for Health Disparities Research in Native Hawaiians and Pacific Islanders. Hawaii J Health Soc Welf. 2021 08; 80(8):195-198. PMID: 34355196.
      Citations:    Fields:    
    2. Watanabe LM, Hashimoto AC, Torres DJ, Alfulaij N, Peres R, Sultana R, Maunakea AK, Berry MJ, Seale LA. Effect of statin treatment in obese selenium-supplemented mice lacking selenocysteine lyase. Mol Cell Endocrinol. 2021 08 01; 533:111335. PMID: 34052303.
      Citations: 1     Fields:    
    3. Go RCP, Corley MJ, Ross GW, Petrovitch H, Masaki KH, Maunakea AK, He Q, Tiirikainen MI. Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson's disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity. BMC Neurosci. 2020 07 10; 21(1):31. PMID: 32650713.
      Citations:    Fields:    Translation:HumansCells
    4. Corley MJ, Vargas-Maya N, Pang APS, Lum-Jones A, Li D, Khadka V, Sultana R, Blanchard DC, Maunakea AK. Epigenetic Delay in the Neurodevelopmental Trajectory of DNA Methylation States in Autism Spectrum Disorders. Front Genet. 2019; 10:907. PMID: 31681403.
      Citations:    
    5. Dye CK, Corley MJ, Li D, Khadka VS, Mitchell BI, Sultana R, Lum-Jones A, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA methylomic analyses reveal potential origins of novel epigenetic biomarkers of insulin resistance in monocytes from virally suppressed HIV-infected adults. Clin Epigenetics. 2019 06 28; 11(1):95. PMID: 31253200.
      Citations: 3     Fields:    Translation:HumansCells
    6. Park SL, Patel YM, Loo LWM, Mullen DJ, Offringa IA, Maunakea A, Stram DO, Siegmund K, Murphy SE, Tiirikainen M, Le Marchand L. Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics. 2018 08 23; 10(1):110. PMID: 30139389.
      Citations: 9     Fields:    Translation:HumansCells
    7. Balaan C, Corley MJ, Eulalio T, Leite-Ahyo K, Pang APS, Fang R, Khadka VS, Maunakea AK, Ward MA. Juvenile Shank3b deficient mice present with behavioral phenotype relevant to autism spectrum disorder. Behav Brain Res. 2019 01 01; 356:137-147. PMID: 30134148.
      Citations: 4     Fields:    Translation:Animals
    8. Lee RWY, Corley MJ, Pang A, Arakaki G, Abbott L, Nishimoto M, Miyamoto R, Lee E, Yamamoto S, Maunakea AK, Lum-Jones A, Wong M. A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder. Physiol Behav. 2018 05 01; 188:205-211. PMID: 29421589.
      Citations: 15     Fields:    Translation:Humans
    9. Corley MJ, Dye C, D'Antoni ML, Byron MM, Yo KL, Lum-Jones A, Nakamoto B, Valcour V, SahBandar I, Shikuma CM, Ndhlovu LC, Maunakea AK. Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment. Sci Rep. 2016 09 15; 6:33310. PMID: 27629381.
      Citations: 10     Fields:    Translation:HumansCells
    10. Pang AP, Sugai C, Maunakea AK. High-throughput sequencing offers new insights into 5-hydroxymethylcytosine. Biomol Concepts. 2016 Jun 01; 7(3):169-78. PMID: 27356236.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Fong KS, Hufnagel RB, Khadka VS, Corley MJ, Maunakea AK, Fogelgren B, Ahmed ZM, Lozanoff S. A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure. Dis Model Mech. 2016 05 01; 9(5):585-96. PMID: 26989192.
      Citations: 6     Fields:    Translation:AnimalsCells
    12. Kraushaar DC, Jin W, Maunakea A, Abraham B, Ha M, Zhao K. Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 2016 Feb 04; 17:21. PMID: 26846280.
      Citations:    Fields:    
    13. Townsend CK, Dillard A, Hosoda KK, Maskarinec GG, Maunakea AK, Yoshimura SR, Hughes C, Palakiko DM, Kehauoha BP, Kaholokula JK. Community-Based Participatory Research Integrates Behavioral and Biological Research to Achieve Health Equity for Native Hawaiians. Int J Environ Res Public Health. 2015 Dec 22; 13(1):ijerph13010004. PMID: 26703660.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    14. Corley MJ, Zhang W, Zheng X, Lum-Jones A, Maunakea AK. Semiconductor-based sequencing of genome-wide DNA methylation states. Epigenetics. 2015; 10(2):153-66. PMID: 25602802.
      Citations: 4     Fields:    Translation:HumansCells
    15. Maunakea AK, Chepelev I, Cui K, Zhao K. Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition. Cell Res. 2013 Nov; 23(11):1256-69. PMID: 23938295.
      Citations: 214     Fields:    Translation:HumansCells
    16. Fu H, Maunakea AK, Martin MM, Huang L, Zhang Y, Ryan M, Kim R, Lin CM, Zhao K, Aladjem MI. Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet. 2013 Jun; 9(6):e1003542. PMID: 23754963.
      Citations: 45     Fields:    Translation:HumansCells
    17. Kraushaar DC, Jin W, Maunakea A, Abraham B, Ha M, Zhao K. Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3. Genome Biol. 2013; 14(10):R121. PMID: 24176123.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    18. Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K. Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5626-31. PMID: 21427231.
      Citations: 46     Fields:    Translation:AnimalsCells
    19. Maunakea AK, Chepelev I, Zhao K. Epigenome mapping in normal and disease States. Circ Res. 2010 Aug 06; 107(3):327-39. PMID: 20689072.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    20. Maunakea AK, Nagarajan RP, Bilenky M, Ballinger TJ, D'Souza C, Fouse SD, Johnson BE, Hong C, Nielsen C, Zhao Y, Turecki G, Delaney A, Varhol R, Thiessen N, Shchors K, Heine VM, Rowitch DH, Xing X, Fiore C, Schillebeeckx M, Jones SJ, Haussler D, Marra MA, Hirst M, Wang T, Costello JF. Conserved role of intragenic DNA methylation in regulating alternative promoters. Nature. 2010 Jul 08; 466(7303):253-7. PMID: 20613842.
      Citations: 702     Fields:    Translation:HumansAnimalsCells
    21. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008 Jun 24; 6:14. PMID: 18577219.
      Citations: 413     Fields:    Translation:HumansAnimalsCells
    22. Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C, Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, Weinstein JN. Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. . 2007 Feb; 6(2):391-403. PMID: 17272646.
      Citations:    
    23. Ching TT, Maunakea AK, Jun P, Hong C, Zardo G, Pinkel D, Albertson DG, Fridlyand J, Mao JH, Shchors K, Weiss WA, Costello JF. Epigenome analyses using BAC microarrays identify evolutionary conservation of tissue-specific methylation of SHANK3. Nat Genet. 2005 Jun; 37(6):645-51. PMID: 15895082.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    24. Hong C, Maunakea A, Jun P, Bollen AW, Hodgson JG, Goldenberg DD, Weiss WA, Costello JF. Shared epigenetic mechanisms in human and mouse gliomas inactivate expression of the growth suppressor SLC5A8. Cancer Res. 2005 May 01; 65(9):3617-23. PMID: 15867356.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    25. Reinhold WC, Kouros-Mehr H, Kohn KW, Maunakea AK, Lababidi S, Roschke A, Stover K, Alexander J, Pantazis P, Miller L, Liu E, Kirsch IR, Urasaki Y, Pommier Y, Weinstein JN. Apoptotic susceptibility of cancer cells selected for camptothecin resistance: gene expression profiling, functional analysis, and molecular interaction mapping. Cancer Res. 2003 Mar 01; 63(5):1000-11. PMID: 12615715.
      Citations: 19     Fields:    Translation:HumansCells
    26. Weinstein JN, Scherf U, Lee JK, Nishizuka S, Gwadry F, Bussey AK, Kim S, Smith LH, Tanabe L, Richman S, Alexander J, Kouros-Mehr H, Maunakea A, Reinhold WC. The bioinformatics of microarray gene expression profiling. Cytometry. 2002 Jan 01; 47(1):46-9. PMID: 11774349.
      Citations: 6     Fields:    Translation:Humans
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