RCMI Coordinating Center (RCMI CC) Header Logo

W. Steven Ward, PhD

TitleDirector, Institute for Biogenesis Research
Faculty RankProfessor
InstitutionUniversity of Hawaii
DepartmentAnatomy, Biochemistry & Physiology
AddressUniversity of Hawaii at Manoa
1960 East-West Rd.
Honolulu HI 96822
Phone8089565189
Fax8089567316
vCardDownload vCard
    Other Positions
    TitleChief, Division Research
    InstitutionJohn A. Burns School of Medicine
    DepartmentObstetrics, Gynecology & Women''s Health


    Collapse Biography 
    Collapse awards and honors
    2014 - 2020Lakshmi Devi and Devraj Sharma Endowed Chair, University of Hawaii

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shen VC, Ward WJ, Chen LK. Systematic review and meta-analysis on the effect of hospital competition on quality of care: Implications for senior care. Arch Gerontol Geriatr. 2019 Jul - Aug; 83:263-270. PMID: 31103920.
      Citations: 1     Fields:    Translation:Humans
    2. Nguyen H, James NG, Nguyen L, Nguyen TP, Vuong C, Ortega MA, Jameson DM, Ward WS. Higher Order Oligomerization of the Licensing ORC4 Protein Is Required for Polar Body Extrusion in Murine Meiosis. J Cell Biochem. 2017 09; 118(9):2941-2949. PMID: 28230328.
      Citations: 4     Fields:    Translation:AnimalsCells
    3. Ortega MA, Ko M, Marh J, Finberg A, Oshiro M, Ward WS. Presence of the Paternal Pronucleus Assists Embryo in Overcoming Cycloheximide Induced Abnormalities in Zygotic Mitosis. J Cell Biochem. 2016 08; 117(8):1806-12. PMID: 26729559.
      Citations:    Fields:    Translation:AnimalsCells
    4. Gawecka JE, Boaz S, Kasperson K, Nguyen H, Evenson DP, Ward WS. Luminal fluid of epididymis and vas deferens contributes to sperm chromatin fragmentation. Hum Reprod. 2015 Dec; 30(12):2725-36. PMID: 26466911.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Ortega MA, Nguyen H, Ward WS. ORC proteins in the mammalian zygote. Cell Tissue Res. 2016 Jan; 363(1):195-200. PMID: 26453397.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    6. Gawecka JE, Ribas-Maynou J, Benet J, Ward WS. A model for the control of DNA integrity by the sperm nuclear matrix. Asian J Androl. 2015 Jul-Aug; 17(4):610-5. PMID: 25926613.
      Citations: 2     Fields:    Translation:HumansCells
    7. Nguyen H, Ortega MA, Ko M, Marh J, Ward WS. ORC4 surrounds extruded chromatin in female meiosis. J Cell Biochem. 2015 May; 116(5):778-86. PMID: 25502171.
      Citations: 7     Fields:    Translation:AnimalsCells
    8. Ward WS, Moisyadi S. Medical school hotline: The Institute for Biogenesis Research: a flower in the Pacific. Hawaii J Med Public Health. 2014 Dec; 73(12):393-6. PMID: 25628972.
      Citations:    Fields:    Translation:Humans
    9. Herzer KR, Niessen L, Constenla DO, Ward WJ, Pronovost PJ. Cost-effectiveness of a quality improvement programme to reduce central line-associated bloodstream infections in intensive care units in the USA. BMJ Open. 2014 Sep 25; 4(9):e006065. PMID: 25256190.
      Citations: 8     Fields:    Translation:Humans
    10. Corey RM, Swett K, Ward WG. Epidemiology and survivorship of soft tissue sarcomas in adults: a national cancer database report. Cancer Med. 2014 Oct; 3(5):1404-15. PMID: 25044961.
      Citations: 19     Fields:    Translation:Humans
    11. Ward WG, Cooper JM, Lippert D, Kablawi RO, Neiberg RH, Sherertz RJ. Glove and gown effects on intraoperative bacterial contamination. Ann Surg. 2014 Mar; 259(3):591-7. PMID: 24045444.
      Citations: 7     Fields:    Translation:HumansCells
    12. Ward WG, Corey RM. To wash or not to wash: that is the question: Commentary on an article by S.J. van Meurs, MD, et al.: "Selection of an optimal antiseptic solution for intraoperative irrigation. An in vitro study". J Bone Joint Surg Am. 2014 Feb 19; 96(4):e34. PMID: 24553903.
      Citations:    Fields:    Translation:Humans
    13. Ribas-Maynou J, Gawecka JE, Benet J, Ward WS. Double-stranded DNA breaks hidden in the neutral Comet assay suggest a role of the sperm nuclear matrix in DNA integrity maintenance. Mol Hum Reprod. 2014 Apr; 20(4):330-40. PMID: 24282283.
      Citations: 11     Fields:    Translation:AnimalsCells
    14. Gawecka JE, Marh J, Ortega M, Yamauchi Y, Ward MA, Ward WS. Mouse zygotes respond to severe sperm DNA damage by delaying paternal DNA replication and embryonic development. PLoS One. 2013; 8(2):e56385. PMID: 23431372.
      Citations: 35     Fields:    Translation:AnimalsCells
    15. Ward WS. Isolation of sperm nuclei and nuclear matrices from the mouse, and other rodents. Methods Mol Biol. 2013; 927:437-44. PMID: 22992934.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    16. Ortega MA, Marh J, Alarcon VB, Ward WS. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep; 87(3):62. PMID: 22674395.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Ward WS. Pum 1 sequesters apoptosis during spermatogenesis. Asian J Androl. 2012 Jul; 14(4):513. PMID: 22522507.
      Citations:    Fields:    Translation:Animals
    18. Yamazaki Y, Ward WS. A new Speedy/RINGO protein may help regulate male meiosis. Asian J Androl. 2011 May; 13(3):363. PMID: 21540866.
      Citations:    Fields:    Translation:Animals
    19. Ward WS. Regulating DNA supercoiling: sperm points the way. Biol Reprod. 2011 May; 84(5):841-3. PMID: 21248288.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Ortega MA, Sil P, Ward WS. Mammalian sperm chromatin as a model for chromatin function in DNA degradation and DNA replication. Syst Biol Reprod Med. 2011 Feb; 57(1-2):43-9. PMID: 21204750.
      Citations:    Fields:    Translation:AnimalsCells
    21. Yamauchi Y, Shaman JA, Ward WS. Non-genetic contributions of the sperm nucleus to embryonic development. Asian J Androl. 2011 Jan; 13(1):31-5. PMID: 20953203.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    22. Dominguez K, Ward WS. A novel nuclease activity that is activated by Ca(2+) chelated to EGTA. Syst Biol Reprod Med. 2009 Dec; 55(5-6):193-9. PMID: 19938954.
      Citations: 7     Fields:    Translation:AnimalsCells
    23. Ward WS. Function of sperm chromatin structural elements in fertilization and development. Mol Hum Reprod. 2010 Jan; 16(1):30-6. PMID: 19748904.
      Citations: 76     Fields:    Translation:HumansCells
    24. Yamauchi Y, Ward MA, Ward WS. Asynchronous DNA replication and origin licensing in the mouse one-cell embryo. J Cell Biochem. 2009 May 15; 107(2):214-23. PMID: 19301258.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Boaz SM, Dominguez K, Shaman JA, Ward WS. Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation. J Cell Biochem. 2008 Apr 01; 103(5):1636-45. PMID: 17879959.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. Shaman JA, Yamauchi Y, Ward WS. The sperm nuclear matrix is required for paternal DNA replication. J Cell Biochem. 2007 Oct 15; 102(3):680-8. PMID: 17415751.
      Citations: 22     Fields:    Translation:AnimalsCells
    27. Umylny B, Presting G, Efird JT, Klimovitsky BI, Ward WS. Most human Alu and murine B1 repeats are unique. J Cell Biochem. 2007 Sep 01; 102(1):110-21. PMID: 17407136.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    28. Umylny B, Presting G, Ward WS. Evidence of Alu and B1 expression in dbEST. Arch Androl. 2007 Jul-Aug; 53(4):207-18. PMID: 17852045.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    29. Shaman JA, Yamauchi Y, Ward WS. Sperm DNA fragmentation: awakening the sleeping genome. Biochem Soc Trans. 2007 Jun; 35(Pt 3):626-8. PMID: 17511666.
      Citations: 1     Fields:    Translation:AnimalsCells
    30. Yamauchi Y, Shaman JA, Boaz SM, Ward WS. Paternal pronuclear DNA degradation is functionally linked to DNA replication in mouse oocytes. Biol Reprod. 2007 Sep; 77(3):407-15. PMID: 17494913.
      Citations: 17     Fields:    Translation:AnimalsCells
    31. Shaman JA, Yamauchi Y, Ward WS. Function of the sperm nuclear matrix. Arch Androl. 2007 May-Jun; 53(3):135-40. PMID: 17612871.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    32. Yamauchi Y, Shaman JA, Ward WS. Topoisomerase II-mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes. Biol Reprod. 2007 Apr; 76(4):666-72. PMID: 17182890.
      Citations: 15     Fields:    Translation:AnimalsCells
    33. Ward WJ, Spragens L, Smithson K. Building the business case for clinical quality. Healthc Financ Manage. 2006 Dec; 60(12):92-8. PMID: 17193836.
      Citations: 1     Fields:    
    34. Shaman JA, Prisztoka R, Ward WS. Topoisomerase IIB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner. Biol Reprod. 2006 Nov; 75(5):741-8. PMID: 16914690.
      Citations: 21     Fields:    Translation:AnimalsCells
    35. Lozanoff S, Ward WS. Department of Anatomy, Biochemistry and Physiology, JABSOM. Hawaii Med J. 2006 May; 65(5):146-7. PMID: 16774144.
      Citations:    Fields:    
    36. Sotolongo B, Huang TT, Isenberger E, Ward WS. An endogenous nuclease in hamster, mouse, and human spermatozoa cleaves DNA into loop-sized fragments. J Androl. 2005 Mar-Apr; 26(2):272-80. PMID: 15713834.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    37. Ward MA, Ward WS. A model for the function of sperm DNA degradation. Reprod Fertil Dev. 2004; 16(5):547-54. PMID: 15355763.
      Citations: 12     Fields:    Translation:HumansCells
    38. Eckardt JJ, Kabo JM, Kelly CM, Ward WG, Cannon CP. Endoprosthetic reconstructions for bone metastases. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S254-62. PMID: 14600617.
      Citations: 10     Fields:    Translation:Humans
    39. Sotolongo B, Lino E, Ward WS. Ability of hamster spermatozoa to digest their own DNA. Biol Reprod. 2003 Dec; 69(6):2029-35. PMID: 12930713.
      Citations: 26     Fields:    Translation:AnimalsCells
    40. Szczygiel MA, Moisyadi S, Ward WS. Expression of foreign DNA is associated with paternal chromosome degradation in intracytoplasmic sperm injection-mediated transgenesis in the mouse. Biol Reprod. 2003 May; 68(5):1903-10. PMID: 12606337.
      Citations: 10     Fields:    Translation:AnimalsCells
    41. Szczygiel MA, Ward WS. Combination of dithiothreitol and detergent treatment of spermatozoa causes paternal chromosomal damage. Biol Reprod. 2002 Nov; 67(5):1532-7. PMID: 12390885.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Mohar I, Szczygiel MA, Yanagimachi R, Ward WS. Sperm nuclear halos can transform into normal chromosomes after injection into oocytes. Mol Reprod Dev. 2002 Jul; 62(3):416-20. PMID: 12112607.
      Citations: 7     Fields:    Translation:AnimalsCells
    43. Ankem MK, Mayer E, Ward WS, Cummings KB, Barone JG. Novel assay for determining DNA organization in human spermatozoa: implications for male factor infertility. Urology. 2002 Apr; 59(4):575-8. PMID: 11927317.
      Citations: 4     Fields:    Translation:HumansCells
    44. Klaus AV, McCarrey JR, Farkas A, Ward WS. Changes in DNA loop domain structure during spermatogenesis and embryogenesis in the Syrian golden hamster. Biol Reprod. 2001 May; 64(5):1297-306. PMID: 11319132.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. Barone JG, Christiano AP, Ward WS. DNA organization in patients with a history of cryptorchidism. Urology. 2000 Dec 20; 56(6):1068-70. PMID: 11113770.
      Citations: 1     Fields:    Translation:HumansCells
    46. McCarthy S, Ward WS. Interaction of exogenous DNA with the nuclear matrix of live spermatozoa. Mol Reprod Dev. 2000 Jun; 56(2 Suppl):235-7. PMID: 10824974.
      Citations:    Fields:    Translation:AnimalsCells
    47. Ward WS, Kishikawa H, Akutsu H, Yanagimachi H, Yanagimachi R. Further evidence that sperm nuclear proteins are necessary for embryogenesis. Zygote. 2000 Feb; 8(1):51-6. PMID: 10840874.
      Citations: 4     Fields:    Translation:AnimalsCells
    48. Sotolongo B, Ward WS. DNA loop domain organization: the three-dimensional genomic code. J Cell Biochem Suppl. 2000; Suppl 35:23-6. PMID: 11389528.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    49. Ward WS, Kimura Y, Yanagimachi R. An intact sperm nuclear matrix may be necessary for the mouse paternal genome to participate in embryonic development. Biol Reprod. 1999 Mar; 60(3):702-6. PMID: 10026119.
      Citations: 24     Fields:    Translation:AnimalsCells
    50. McCarthy S, Ward WS. Functional aspects of mammalian sperm chromatin. Hum Fertil (Camb). 1999; 2(1):56-60. PMID: 11844327.
      Citations: 2     Fields:    
    51. Perrotti M, Rabbani F, Farkas A, Ward WS, Cummings KB. Trends in poorly differentiated prostate cancer 1973 to 1994: observations from the Surveillance, Epidemiology and End Results database. J Urol. 1998 Sep; 160(3 Pt 1):811-5. PMID: 9720554.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    52. Niemczyk P, Cummings KB, Sarvazyan AP, Bancila E, Ward WS, Weiss RE. Correlation of mechanical imaging and histopathology of radical prostatectomy specimens: a pilot study for detecting prostate cancer. J Urol. 1998 Sep; 160(3 Pt 1):797-801. PMID: 9720551.
      Citations: 5     Fields:    Translation:Humans
    53. Farkas A, Schneider D, Perrotti M, Cummings KB, Ward WS. National trends in the epidemiology of prostate cancer, 1973 to 1994: evidence for the effectiveness of prostate-specific antigen screening. Urology. 1998 Sep; 52(3):444-8; discussion 448-9. PMID: 9730458.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    54. Tateno H, Wakayama T, Ward WS, Yanagimachi R. Can alcohol retain the reproductive and genetic potential of sperm nuclei? Chromosome analysis of mouse spermatozoa stored in alcohol. Zygote. 1998 Aug; 6(3):233-8. PMID: 9854795.
      Citations: 2     Fields:    Translation:AnimalsCells
    55. Farkas A, Schneider D, Cummings KB, Ward WS. Is prostate cancer screening analogous to lung cancer screening? JAMA. 1997 Apr 09; 277(14):1120; author reply 1121-2. PMID: 9087461.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    56. Ward WS, McNeil J, de Lara J, Lawrence J. Localization of three genes in the hook-shaped hamster sperm nucleus by fluorescent in situ hybridization. Biol Reprod. 1996 Jun; 54(6):1271-8. PMID: 8724355.
      Citations: 1     Fields:    Translation:AnimalsCells
    57. Ward WS, Zalensky AO. The unique, complex organization of the transcriptionally silent sperm chromatin. Crit Rev Eukaryot Gene Expr. 1996; 6(2-3):139-47. PMID: 8855386.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    58. Nadel B, De Lara J, Ward WS. Structure of the rRNA genes in the hamster sperm nucleus. J Androl. 1995 Nov-Dec; 16(6):517-22. PMID: 8867600.
      Citations: 3     Fields:    Translation:AnimalsCells
    59. Nadel B, de Lara J, Finkernagel SW, Ward WS. Cell-specific organization of the 5S ribosomal RNA gene cluster DNA loop domains in spermatozoa and somatic cells. Biol Reprod. 1995 Nov; 53(5):1222-8. PMID: 8527528.
      Citations: 7     Fields:    Translation:AnimalsCells
    60. Ji P, Karim OM, Boyd CD, Mostwin JL, Ward WS. Elastin morphology in normal and obstructed guinea-pig bladders. Localization of elastin to the trigone. World J Urol. 1995; 13(3):191-4. PMID: 7550394.
      Citations:    Fields:    Translation:Animals
    61. Ward WS. The structure of the sleeping genome: implications of sperm DNA organization for somatic cells. J Cell Biochem. 1994 May; 55(1):77-82. PMID: 8083302.
      Citations: 10     Fields:    Translation:AnimalsCells
    62. Barone JG, De Lara J, Cummings KB, Ward WS. DNA organization in human spermatozoa. J Androl. 1994 Mar-Apr; 15(2):139-44. PMID: 8056637.
      Citations: 11     Fields:    Translation:HumansCells
    63. Pienta KJ, Ward WS. An unstable nuclear matrix may contribute to genetic instability. Med Hypotheses. 1994 Jan; 42(1):45-52. PMID: 8196560.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    64. de Lara J, Wydner KL, Hyland KM, Ward WS. Fluorescent in situ hybridization of the telomere repeat sequence in hamster sperm nuclear structures. J Cell Biochem. 1993 Nov; 53(3):213-21. PMID: 8263038.
      Citations: 5     Fields:    Translation:AnimalsCells
    65. Ward WS. Deoxyribonucleic acid loop domain tertiary structure in mammalian spermatozoa. Biol Reprod. 1993 Jun; 48(6):1193-201. PMID: 8318576.
      Citations: 10     Fields:    Translation:AnimalsCells
    66. Cummings KB, Barone JG, Ward WS. Diagnosis and staging of bladder cancer. Urol Clin North Am. 1992 Aug; 19(3):455-65. PMID: 1636230.
      Citations: 7     Fields:    Translation:Humans
    67. Getzenberg RH, Pienta KJ, Ward WS, Coffey DS. Nuclear structure and the three-dimensional organization of DNA. J Cell Biochem. 1991 Dec; 47(4):289-99. PMID: 1795013.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    68. Ward WS, Coffey DS. DNA packaging and organization in mammalian spermatozoa: comparison with somatic cells. Biol Reprod. 1991 Apr; 44(4):569-74. PMID: 2043729.
      Citations: 109     Fields:    Translation:AnimalsCells
    69. Farrington JE, Patel R, Ward WS. DNA attachment to the hamster sperm nuclear matrix and nuclear annulus. Ann N Y Acad Sci. 1991; 637:164-74. PMID: 1785770.
      Citations:    Fields:    Translation:AnimalsCells
    70. Ward WS, Coffey DS. Specific organization of genes in relation to the sperm nuclear matrix. Biochem Biophys Res Commun. 1990 Nov 30; 173(1):20-5. PMID: 2175176.
      Citations: 5     Fields:    Translation:AnimalsCells
    71. Carter BS, Ewing CM, Ward WS, Treiger BF, Aalders TW, Schalken JA, Epstein JI, Isaacs WB. Allelic loss of chromosomes 16q and 10q in human prostate cancer. Proc Natl Acad Sci U S A. 1990 Nov; 87(22):8751-5. PMID: 1978938.
      Citations: 81     Fields:    Translation:HumansCells
    72. Ward WS, Partin AW, Coffey DS. DNA loop domains in mammalian spermatozoa. Chromosoma. 1989 Sep; 98(3):153-9. PMID: 2582896.
      Citations: 16     Fields:    Translation:AnimalsCells
    73. Ward WS, Coffey DS. Identification of a sperm nuclear annulus: a sperm DNA anchor. Biol Reprod. 1989 Aug; 41(2):361-70. PMID: 2804224.
      Citations: 9     Fields:    Translation:AnimalsCells
    74. Wedrychowski A, Schmidt WN, Ward WS, Hnilica LS. Cross-linking of cytokeratins to DNA in vivo by chromium salt and cis-diamminedichloroplatinum(II). Biochemistry. 1986 Jan 14; 25(1):1-9. PMID: 2420355.
      Citations: 2     Fields:    Translation:Animals
    75. Ward WS, Schmidt WN, Schmidt CA, Hnilica LS. Cross-linking of Novikoff ascites hepatoma cytokeratin filaments. Biochemistry. 1985 Jul 30; 24(16):4429-34. PMID: 2413887.
      Citations: 3     Fields:    Translation:Animals
    76. Wedrychowski A, Ward WS, Schmidt WN, Hnilica LS. Chromium-induced cross-linking of nuclear proteins and DNA. J Biol Chem. 1985 Jun 10; 260(11):7150-5. PMID: 3997861.
      Citations: 15     Fields:    Translation:Animals
    77. Schmidt WN, Page DL, Schmidt CA, McKusick KB, Ward WS, Hnilica LS. Characterization of monoclonal antibodies to novikoff hepatoma cytokeratin antigen p39. Cancer Res. 1984 Dec; 44(12 Pt 1):5867-79. PMID: 6209005.
      Citations: 2     Fields:    Translation:AnimalsCells
    78. Ward WS, Schmidt WN, Schmidt CA, Hnilica LS. Association of cytokeratin p39 with DNA in intact Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1984 Jan; 81(2):419-23. PMID: 6198648.
      Citations: 4     Fields:    Translation:AnimalsCells
    Ward's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (287)
    Explore
    _
    Co-Authors (8)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    RCMI CC is supported by the National Institute on Minority Health and Health Disparities, National Institutes of Health (NIH), through Grant Number U24MD015970. The contents of this site are solely the responsibility of the authors and do not necessarily represent the official views of the NIH

    For technical support please contact support