I spent my first 15 years on the faculty at the University of Texas Southwestern Medical Center where I pursued molecular investigations of cardiovascular biology. There I developed my interests in hypoxia and technology development which are presently the central efforts of my lab. I moved to the University of Hawaii in December 2005 to help JABSOM fulfill its promise to become an advanced biomedical research institution. We established a Center for Cardiovascular Research and with the support of a renewed COBRE grant, and substantial institutional support, we have created a sustainable, nationally competitive effort in cardiovascular basic science. We work closely with the other infrastructure programs, including the other COBREs, RCMI, and R-CTR efforts, to develop complementary Core resources, provide mentored career development opportunities for young investigators, enhance biomedical education, and discover new understanding of medically important biology.